290 件 ・ 関連度順
概要と使いどころ
Audit pricing research and sensitivity analysis systems for Van Westendorp price sensitivity meter (OPP/IDP/PMC/PME intersections), Gabor-Granger demand curves, Newton-Miller-Smith revenue extension, price elasticity econometric modeling, willingness-to-pay estimation.
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Analyze an insurance claims processing system for lifecycle completeness, straight-through processing automation, fraud detection coverage, reserve estimation methodology, subrogation recovery workflows, and regulatory compliance with state prompt payment laws..
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Analyze mining equipment maintenance systems including heavy fleet condition monitoring (oil analysis, vibration per ISO 17359/10816, thermal imaging), predictive analytics with Weibull reliability modeling and remaining useful life estimation.
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Analyze defense program budgets and acquisition costs — earned value management (EVM/CPI/SPI), should-cost modeling, PPBE process alignment, cost estimation per GAO guidelines, Nunn-McCurdy breach risk, FYDP profiles, and learning curve analysis. Audit DoD 5000 acquisition software, program cost databases, and budget justification systems.
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Analyze consumer modeling systems for purchase prediction, lifetime value estimation, multi-touch attribution, brand affinity, and switching cost analysis. Triggers: 'evaluate CLV model', 'review purchase prediction', 'audit attribution model', 'assess customer lifetime value'.
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Analyze catastrophe modeling systems for natural disaster exposure, PML estimation, and reinsurance optimization. Use when: 'assess cat model', 'evaluate disaster exposure', 'review PML calculations', 'audit reinsurance program', 'check exposure data quality', 'analyze hurricane/earthquake risk models', 'evaluate Oasis or RMS setup'.
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Prospective failure imagination for a plan, decision, or running system. Operates in two modes — **plan mode** (a plan has not yet been committed to; imagine its catastrophic failure broadly) and **scenario mode** (a specific catastrophic scenario is posed against an existing system; investigate causes against the actual code and architecture). Spawns parallel pre-mortemers in isolation across three categories of lens: standard failure classes (technical, operational, estimation, scope, adoption, dependency, team, incentive, detection, reversibility, adversarial), 0-3 ad-hoc target-specific lenses the orchestrator names when warranted, and a first-principles lens that always runs to catch what the prescribed taxonomy misses. Synthesizes into a prioritized risk register with early-warning signals. Produces feedback only — no code, no tickets, no artifacts.
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Dose-response modeling — EC50 estimation, curve fitting, synergy analysis, and benchmark-dose methods.
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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
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Design and implement adaptive testing systems using Item Response Theory (IRT). Use when working with computerized adaptive tests (CAT), psychometric assessment, ability estimation, question calibration, test design, or IRT models (1PL/2PL/3PL). Covers test algorithms, stopping rules, item selection strategies, and practical implementation patterns for K-12, certification, placement, and diagnostic assessments.
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Evaluate Jira ticket complexity and inconsistencies via jira-evaluator agent, read-only. NOT estimation (mk:jira-estimator) or full RCA (mk:jira-analyst).
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Heuristic read-only story-point estimation for one Jira ticket via jira-estimator agent. NOT complexity analysis (mk:jira-evaluator) or full RCA (mk:jira-analyst).
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Read-only full Jira ticket analysis incl. media + linked issues via jira-analyst agent; produces comment-ready findings. NOT complexity scoring (mk:jira-evaluator) or estimation (mk:jira-estimator).
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Evaluate Jira ticket complexity + inconsistencies via the jira-evaluator agent. Read-only. Triggers: 'evaluate KEY', 'analyze ticket complexity for KEY', 'check ticket quality for KEY'. NOT for estimation (mk:jira-estimator); NOT for full RCA (mk:jira-analyst).
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Full Jira ticket context analysis via the jira-analyst agent — including media (attached images / PDFs / screenshots) and linked issues. Produces structured findings suitable for posting back as a Jira comment. Read-only. Triggers: 'analyze KEY', 'rca for KEY', 'describe KEY with media'. NOT for complexity scoring (mk:jira-evaluator); NOT for story-point estimation (mk:jira-estimator).
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Corrects fluorophore spillover (conventional compensation) or spectral overlap (spectral unmixing) and applies variance-stabilizing transforms (logicle/biexponential, arcsinh, log) for flow and mass cytometry. Covers spillover-matrix estimation from single-stain controls, AutoSpill, the spillover spreading matrix and why panel design (not compensation) bounds resolution, compensate-then-transform ordering, and arcsinh cofactor choice (5 for CyTOF, ~150 for fluorescence, per-channel via flowVS). Use when correcting spectral overlap, preparing data for gating/clustering, choosing logicle vs arcsinh, deciding a cofactor, or distinguishing compensation from spectral unmixing.
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Estimates the minimum biological replicates (or cells/events) for a target power at a target FDR in genomics experiments using ssizeRNA, PROPER, powsimR for scRNA-seq, and pilot-data dispersion estimation from DESeq2/edgeR. Covers the biological-versus-technical replication distinction (technical replicates do not add degrees of freedom for biological inference), replicate-number-versus-sequencing-depth budgeting, scRNA-seq sample-versus-cell allocation under a pseudobulk model, and the critique that "n=3" is a publication convention rather than a power calculation. Use when budgeting a sequencing experiment, writing the sample-size justification in a grant, estimating replicates from pilot data, allocating a fixed budget between samples and depth, or planning scRNA-seq cohort size. For clinical-trial sample size see clinical-biostatistics/power-and-sample-size; for the power-given-n direction see experimental-design/power-analysis.
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Analyzes time-series and longitudinal RNA-seq for differential expression and trajectory structure. Covers DESeq2 LRT with reduced models, time as factor vs continuous vs natural splines, maSigPro (Nueda 2014 for RNA-seq), ImpulseDE2 with explicit impulse-model failure modes, DREAM for repeated measures via linear mixed models, pseudoreplication avoidance, conditional vs marginal modeling, and trajectory clustering with DPGP, Mfuzz (with Schwämmle 2010 fuzzifier estimation), and splines+k-means. Use when modeling time-course or longitudinal expression, choosing factor vs spline, handling repeated measures from the same subject, avoiding pseudoreplication, clustering temporal trajectories, or selecting between dedicated time-course tools and pairwise+LRT.
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Assesses genetic health of populations for conservation with Ne estimation across time horizons (LDNe NeEstimator V2 option-file API + SNeP physical-linkage correction; recent trajectory via GONE/GONE2; deep history via Stairway Plot 2 / dadi / fastsimcoal2 / PSMC), F-statistics, runs of homozygosity binned by length class to date inbreeding, genetic-load decomposition (Bertorelle 2022 realized vs masked), the modern 100/1000 Ne rule (Frankham 2014), Ne/Nc 2-6 orders of magnitude in marine fish (Hauser & Carvalho 2008), tree-sequence forward simulations (SLiM 4 + pyslim + tskit), and the Sukumaran-Knowles caveat against MSC methods for management-unit definition. Use when estimating Ne by time horizon, detecting inbreeding via F_ROH, decomposing genetic load, justifying conservation thresholds, distinguishing ESU/MU/DPS, configuring NeEstimator V2, or correcting LDNe physical linkage.
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Performs differential expression on bulk RNA-seq count data with edgeR's negative-binomial GLM and quasi-likelihood F-test framework. Covers DGEList construction, filterByExpr, TMM/TMMwsp normalization, robust dispersion estimation, glmQLFit/glmQLFTest, TREAT for magnitude-bounded hypotheses, contrasts via no-intercept designs, voom and voomWithQualityWeights for heterogeneous samples, and the edgeR v4 bias-corrected APL changes. Use when running bulk DE with edgeR, choosing edgeR over DESeq2 (small n, transcript DE via catchSalmon, large samples), needing TREAT for a fold-change-threshold hypothesis, troubleshooting v3-to-v4 reproducibility, building paired or interaction designs, or handling library-quality heterogeneity.
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Reconcile gene trees against a species tree under probabilistic models of duplication, transfer, and loss (DTL) using ALE (Szöllősi 2013 amalgamated likelihood), GeneRax (Morel 2020 ML reconciliation), AleRax (Morel 2024 co-estimation), Whale.jl (Bayesian DL+WGD), RANGER-DTL 2 parsimony, NOTUNG, ecceTERA, and Treerecs. Use when inferring ancestral gene-family content, distinguishing duplication from horizontal transfer from differential loss, rooting deep species trees from gene-content signals (STRIDE / Williams 2017 ALE-rooting), counting DTL events per branch, refining noisy gene trees against a species tree, modeling WGD events jointly with DTL, or producing publication-grade gene-family histories for phylogenomic / comparative analyses.
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Decides how to preprocess plasma cfDNA sequencing data so the recoverable signal survives - library-prep-aware fragment expectations (dsDNA vs ssDNA/adaptase prep), UMI/duplex consensus with fgbio (ExtractUmisFromBam, GroupReadsByUmi --strategy paired for duplex, CallMolecularConsensusReads vs CallDuplexConsensusReads, FilterConsensusReads min-reads "total s1 s2"), the align->group->consensus->RE-align ordering, and the cfDNA dedup trap where naive coordinate dedup collapses nucleosome-coincident independent molecules. Covers when single-strand consensus suffices vs when duplex is mandatory, the singleton/sensitivity tax at low input, and reading the insert-size histogram as a pre-analytical QC instrument. Use when processing plasma cfDNA reads before fragmentomics, ctDNA mutation calling, or tumor-fraction estimation.
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This skill provides AWS cost optimization, monitoring, and operational best practices with integrated MCP servers for billing analysis, cost estimation, observability, and security assessment.
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Time-blind friendly planning, executive function support, and daily structure for ADHD brains. Specializes in realistic time estimation, dopamine-aware task design, and building systems that actually work for neurodivergent minds.
日本語の概要は準備中です。原文の説明を表示しています。