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概要と使いどころ
Create a PR to the main branch for feature/fix changes in this pnpm + Changesets monorepo. Use when the user says "PRを作成", "mainにPR", or wants to submit changes for review. Always run this in the monorepo-aware way — identify the affected package(s) and make sure a changeset exists, because the release pipeline is Changesets-driven.
Security payloads, bypass tables, wordlists, gf pattern names, always-rejected bug list, and conditionally-valid-with-chain table. Use when you need specific payloads for XSS/SSRF/SQLi/XXE/NoSQLi/command injection/SSTI/IDOR/path-traversal/HTTP smuggling/WebSocket/MFA bypass, or bypass techniques. Submittability and the always-rejected / what-NOT-to-submit decision are owned by triage-validation.
日本語の概要は準備中です。原文の説明を表示しています。
Designs complete research plans that integrate clinical variables with multi-omics data from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a study that combines clinical variables with transcriptomics, proteomics, metabolomics, epigenomics, or related omics layers for mechanism interpretation, biomarker development, risk stratification, treatment-response analysis, or translational use. It should define the clinical use case, alignment across data layers, feature-reduction and fusion logic, modeling route, mechanism-interpretation layer, validation ladder, and four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, platform coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.
日本語の概要は準備中です。原文の説明を表示しています。
Converts an audited medical research gap into a complete, structured, gap-traceable study design. Always use this skill whenever a user already has one or more candidate research gaps and wants to transform them into an executable biomedical research plan rather than re-run broad topic ideation. Covers six gap-to-design patterns (evidence-completion, mechanism-resolution, cell-state/context-mapping, translation-bridge, causality-upgrade, population/stage-specific) and always outputs one recommended primary protocol, a gap-to-design dependency map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and verified design-support literature rules. Never fabricate references. Preserve claim-evidence discipline and do not replace a topic-specific gap with a generic workflow.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete tumor immune-infiltration-guided bulk-transcriptome diagnostic biomarker and machine-learning research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, immune infiltration estimation, immune-linked module discovery, consensus feature selection, diagnostic modeling, nomogram construction, clinical association, and optional prognostic extension or validation. Covers five study patterns (immune-cell-first diagnostic workflow, immune-module-to-biomarker workflow, consensus-ML biomarker workflow, diagnostic-plus-prognostic hybrid workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, reference literature pack, and self-critical risk review.
日本語の概要は準備中です。原文の説明を表示しています。
Designs complete single-cell research plans from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a single-cell study — including disease-focused, mechanism-focused, biomarker-focused, translational, perturbation-inspired, or validation-aware projects. It should define the research question, choose the best-fit study pattern, recommend sample grouping logic, suggest reference datasets as examples only, specify the core analysis modules, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, sample metadata, accession numbers, cohort availability, cell-type labels, external validation resources, or literature references. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete NHANES-style cross-sectional epidemiology + retrospective clinical validation research designs from a user-provided disease and biomarker direction. Always use this skill whenever a user wants to design, plan, or build a population-level biomarker association study using NHANES or similar survey datasets, especially when the article logic includes disease definition, biomarker formula derivation, multivariable logistic regression, restricted cubic spline analysis, subgroup stability testing, and a secondary hospital-based retrospective validation cohort. Covers five study patterns (cross-sectional association, dose-response / RCS, subgroup-stability, NHANES + retrospective validation, preliminary screening-performance) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete programmed-cell-death (PCD) / regulated-cell-death (RCD) bulk-transcriptome oncology research designs from a user-provided disease and mechanism theme. Always use this skill whenever a user wants to design, plan, or structure a cancer bioinformatics study built around cell-death patterns, tumor microenvironment, prognostic modeling, immune landscape analysis, mutation profiling, and computational drug sensitivity. Covers five study patterns (mechanism-gene-set, subtype-discovery, prognostic-signature, immune-response stratification, translational drug-hypothesis) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete Mendelian Randomization + single-cell transcriptomics (scRNA-seq) research designs from a user-provided direction. Always use this skill whenever a user wants to design, plan, or build a study combining MR and single-cell data — even if phrased as "help me write a paper on X", "design a bioinformatics study for Y", or "I want to study Z using MR and scRNA". Covers five study patterns (mechanism gene-set, key-cell, candidate-gene reverse validation, exposure-disease-cell triangulation, translational biomarker) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete cross-disease shared-biomarker bioinformatics research designs from a user-provided disease pair and validation direction. Always use this skill whenever a user wants to design, plan, or build a multi-dataset study linking two related diseases through shared DEGs, enrichment, PPI hub genes, public validation, regulatory-network analysis, immune infiltration, drug-gene interaction screening, and optional qRT-PCR or cell-line validation. Covers five study patterns (shared-DEG discovery, hub-gene prioritization, regulatory-network interpretation, immune/drug follow-up, bioinformatics-plus-validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, and a strictly verified reference literature retrieval layer with real references only.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete dual-disease shared-transcriptome biomarker and hub-gene research designs from a user-provided disease pair and shared-biology direction. Always use this skill whenever a user wants to design, plan, or build a non-oncology two-disease transcriptome study centered on per-disease differential expression, shared-signal intersection or concordance, PPI-based hub-gene prioritization, diagnostic evaluation across both diseases, immune infiltration context, pathway interpretation, and optional orthogonal validation. Covers five study patterns (shared-DEG-first workflow, hub-gene-first shared-biomarker workflow, hybrid shared-biomarker compression workflow, immune-context shared-biomarker workflow, orthogonal validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete reference-grounded single-drug adverse-effect network-pharmacology research designs from a user-provided drug, adverse event, and desired evidence depth. Always use this skill when a user wants to design, plan, or upgrade a conventional network-pharmacology study centered on one fixed drug and one fixed adverse-effect endpoint, using drug-target prediction, adverse-event target collection, overlap analysis, PPI hub prioritization, enrichment interpretation, molecular docking, and optional orthogonal transcriptomic or literature validation. Covers five study patterns (canonical hub-first, cardiotoxicity or electrophysiology-oriented, immune-inflammatory adverse effect, organ-toxicity pathway context, translational validation) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, dependency/evidence map, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path, verified-reference pack, and self-critical risk review.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete Mendelian randomization study designs from a user-provided exposure and outcome direction. Always use this skill whenever a user wants to design, plan, or build a Mendelian randomization study — even if phrased as "help me write a paper on X", "design an MR study for Y", or "I want to test whether A causally affects B using GWAS". Covers core two-sample MR design, optional bidirectional follow-up, optional multivariable MR, IV selection logic, ancestry alignment, harmonization, IVW as the default primary estimator, weighted median / MR-Egger / MR-PRESSO / leave-one-out sensitivity analyses, Steiger directionality, heterogeneity / pleiotropy checks, and explicit claim-boundary control. Always outputs four workload configs (Lite / Standard / Advanced / Publication+) with a recommended primary plan, stepwise workflow, method rationale, validation ladder, figure plan, minimal executable version, and strictly verified literature guidance with no fabricated references.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete conventional oncology bulk-transcriptome biomarker and hub-gene research designs from a user-provided cancer type and study direction. Always use this skill whenever a user wants to design, plan, or build a tumor bioinformatics study centered on differential expression, prognostic filtering or risk modeling, PPI-based hub-gene prioritization, diagnostic/prognostic evaluation, clinical association, immune infiltration context, methylation context, and optional tissue or cell validation. Covers five study patterns (signature-first prognostic workflow, hub-gene-first biomarker workflow, hybrid signature-to-hub workflow, immune-context biomarker workflow, translational validation workflow) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version, publication upgrade path...
日本語の概要は準備中です。原文の説明を表示しています。
Designs complete integrated research plans for bulk transcriptomics, proteomics, metabolomics, and related omics from a user-provided biomedical direction. Always use this skill whenever a user wants to design, scope, or structure a bulk multi-omics or single-omics-plus-clinical study — including disease-focused, mechanism-focused, biomarker-focused, stratification-oriented, or translational projects. It should define the research question, choose the best-fit study pattern, recommend example datasets as reference candidates only, specify the core analysis modules and method choices, propose a validation ladder, and output four workload configurations (Lite / Standard / Advanced / Publication+). Never fabricate datasets, accession numbers, sample counts, metadata completeness, cohort availability, assay coverage, literature references, PMIDs, DOIs, or validation status. Always include the mandatory Dataset Disclaimer immediately before any workflow section that mentions datasets or public resources.
日本語の概要は準備中です。原文の説明を表示しています。
Generates complete bidirectional multi-phenotype Mendelian randomization research designs from a user-provided exposure family and outcome family. Always use this skill whenever a user wants to design, plan, or build a genome-wide causal-inference study based on publicly available GWAS summary statistics, especially when the article logic includes multiple exposures, multiple outcomes or subtypes, bidirectional MR, IV filtering, IVW as the main estimator, weighted median / MR-Egger / MR-PRESSO sensitivity analyses, leave-one-out testing, heterogeneity / pleiotropy checks, and multiple-testing control with FDR. Covers five study patterns (single-family bidirectional MR, multi-phenotype screening MR, subtype-resolved MR, phenome-style bidirectional causal map, mechanism-prioritized MR follow-up) and always outputs four workload configs (Lite / Standard / Advanced / Publication+) with recommended primary plan, step-by-step workflow, figure plan, validation strategy, minimal executable version...
日本語の概要は準備中です。原文の説明を表示しています。
ALWAYS invoke this skill when the user asks what to do next, what is left, or what is blocked - "what's next", "what now", "what should we work on", "anything I can do" - in any language. This skill picks the next piece of work; when the user asks HOW to do a thing or says they do not understand what to do, that is os-step-by-step. Reads the last report, local changes, open pull requests and always the backlog. First finishes what is finished: verified-ready pull requests merge in the same pass. Then sorts the rest into doable-alone and needs-you, ending with one recommended next task in plain words - what it closes or unblocks. Never invents tasks.
日本語の概要は準備中です。原文の説明を表示しています。
Complete sanctions and export control analysis tool — individual designations, sectoral sanctions, dual-use goods, payment systems (SWIFT/USD), and extraterritorial regimes (EAR/ITAR/ FDPR US, ECL China). Triggers: "is X sanctioned?", "can I do business with X?", "can I sell Y to Z?", "pétrole Russie", "biens à double usage", "gel des avoirs", "sanctions internationales", "liste OFAC", "liste UE", "double usage", "embargo", "licence d'exportation", "SWIFT", "paiement en dollars", "US goods", "FDPR", "EAR", "ITAR", "BIS", "ECL chine", "no re-export clause", "sanctions sectorielles", "puis-je travailler avec X?", or any transaction involving a foreign person, product, sector, destination country, or payment in USD/EUR. Always adapt to user profile. Always run for any sanctions or export control query — even vague or exploratory ones.
日本語の概要は準備中です。原文の説明を表示しています。
Retrieves up-to-date documentation, API references, and code examples for any developer technology. Use this skill whenever the user asks about a specific library, framework, SDK, CLI tool, or cloud service — even for well-known ones like React, Next.js, Prisma, Express, Tailwind, Django, or Spring Boot. Your training data may not reflect recent API changes or version updates. Always use for: API syntax questions, configuration options, version migration issues, "how do I" questions mentioning a library name, debugging that involves library-specific behavior, setup instructions, and CLI tool usage. Use even when you think you know the answer — do not rely on training data for API details, signatures, or configuration options as they are frequently outdated. Always verify against current docs. Prefer this over web search for library documentation and API details.
日本語の概要は準備中です。原文の説明を表示しています。
Analyze assertion quality, depth, variety, and false confidence in existing tests. ALWAYS USE when asked about weak, shallow, trivial, always-true, self-referential, assertion-free, presence/truthiness-only, or insufficiently diverse assertions, including MSTest, Jest, pytest, and Go. DO NOT USE for direct fixes: writing-mstest-tests owns supplied MSTest assertions; code-testing owns new cases. Use test-gap-analysis when asked whether tests would catch a production change, and test-anti-patterns for general severity-ranked audits.
日本語の概要は準備中です。原文の説明を表示しています。
Twig coding standards and conventions for Craft CMS 5 templates. ALWAYS load this skill when writing, editing, or reviewing any .twig file in a Craft CMS project — even for small edits. Covers: variable naming (camelCase, no abbreviations), null handling (?? operator, ??? with empty-coalesce plugin), whitespace control ({%- trimming, NOT {%- minify -%}), include isolation (always use 'only'), Craft Twig helpers ({% tag %}, tag(), attr(), |attr filter, |parseAttr, |append, svg()), collect() for props and class collections, .implode(), comment headers with ========= separators on component files, and common pitfalls (snake_case, macros as components, hardcoded colors).
日本語の概要は準備中です。原文の説明を表示しています。
Discover and install agent skills from the open ecosystem (skills.sh), optimized for Japanese users. Use when the user asks 'how do I do X', 'is there a skill for X', or in Japanese 「〜できる？」「〜のスキルある？」「スキルを探して」「〜を自動化したい」「〜を効率化したい」. Always converts Japanese intent into short English search keywords before searching (the registry matches English keywords only), and verifies skill quality and safety before recommending installation.
Selects the active profile from triggering context. Evaluates a rule set against inputs (current time, calendar state, geofence, manual command, custom signals) and returns the profile name that consuming Skills (handoff-trigger-check, critic-gate, future Skills) should apply. Configuration-driven; rule set lives in a router config file conforming to the included schema. Deterministic precedence — manual override beats calendar beats time-window beats default. Required default profile guarantees a routing decision always exists. Use when an orchestrator needs to pick a profile automatically rather than having the caller specify one, when wiring calendar/time/Telegram triggers to gate behavior, or when a Skill's behavior should change with availability mode. Trigger on: "what profile should I use," "route to a profile," "which mode am I in," "auto-select profile," "active mode," "current profile." Do NOT use to evaluate work readiness or review proposed changes. Always returns a profile name.
日本語の概要は準備中です。原文の説明を表示しています。