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Expert Section 508 compliance advisor for US federal ICT accessibility. Use this skill whenever a user asks about Section 508, WCAG 2.0/2.1 AA for federal systems, VPAT or Accessibility Conformance Reports (ACR), accessibility audits, remediation planning, PDF accessibility, web or software accessibility, mobile accessibility, federal procurement accessibility requirements, contractor obligations, undue burden exceptions, assistive technology compatibility, or Section 508 testing. Covers the Revised Section 508 Standards (2018), all WCAG 2.0 Level AA success criteria, the four POUR principles, testing methodologies, and agency compliance workflows. Trigger even if the user doesn't say "skill" — any Section 508 or ICT accessibility question for federal systems should use this skill.

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Invoice review, non-compliance flagging, rejection communication, billing trend analysis, and conversation preparation for in-house legal ops teams managing outside counsel. Review invoices against billing guidelines; flag block billing, prohibited fees, rate violations, staffing violations, late submission. Produce line-item review report and approval note. Draft rejection letter to outside counsel. Build invoice review checklist. Analyse billing trends across multiple invoices and produce a structured conversation guide for the relationship review. Identify systemic patterns and produce formal non-compliance notice. Trigger on: 'review this invoice', 'flag billing issues', 'check invoice against guidelines', 'write the rejection letter', 'build an invoice checklist', 'block billing', 'UTBMS', 'billing non-compliance', 'analyse our invoices', 'billing trends', 'prep for the billing conversation', 'relationship review', 'the firm keeps doing this', 'escalate'.

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Addresses HIPAA compliance for mobile health (mHealth) applications, wearable devices, and remote patient monitoring. Covers OCR guidance on mobile device PHI, FDA-regulated mobile medical applications, FTC Health Breach Notification Rule for non-HIPAA apps, BYOD policies, and encryption requirements for ePHI on mobile platforms. Keywords: mHealth, mobile health, HIPAA mobile, wearable, remote monitoring, BYOD, mobile device management, app privacy.

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Use when user asks to create/design a big screen (大屏), full-screen data visualization, or says "创建大屏", "生成大屏", "新建大屏", "设计大屏", "做一个大屏", "BI大屏", "数据大屏", "可视化大屏", "监控大屏", "create big screen", "design big screen", "BI visualization big screen". Also triggers when user describes big screen requirements like "做一个销售数据大屏" or mentions full-screen display like "展厅展示", "监控室大屏". Make sure to use this skill for big screens (大屏) — NOT dashboards (仪表盘/看板), which use a completely different layout and styling system.

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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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临床诊断思维 (临床诊断思维 / 临床推理 (Clinical Diagnostic Reasoning) — 医生『怎么想病』的元学科:从症状/体征/检查到诊断结论的认知操作系统,从业者(临床医生/住院医/规培生,尤其全科/急诊/大内科等以未分化主诉为生的科室)、医学生与医学教育者、诊断安全与质量改进研究者、以及做医疗 AI 辅助诊断产品的人的视角。覆盖: (a) 第一性张力 — **直觉模式识别 (System 1: illness scripts 疾病脚本 / pattern recognition / gestalt, 『资深人一眼认出 aunt Minnie』) ⇄ 分析性推理 (System 2: hypothetico-deductive 假设演绎 / Bayesian 概率更新)** 的 dual-process 双过程理论 (Kahneman→Croskerry/Norman 谱系), 资深≠更会分析而是『脚本库更大+校准更好』; 更深层论战 — **『认知去偏可教 (Croskerry: bias awareness / cognitive forcing strategies / diagnostic timeout) ⇄ 偏倚标签是马后炮、知识结构才是主因 (Norman/Sherbino/Monteiro: debiasing 干预 transfer 证据弱, bias 是 hindsight 标签)』** — 本行最核心学术对垒; 『概率思维 (验前概率 × 似然比 → 验后概率, Pauker-Kassirer test/treatment threshold 阈值模型) ⇄ 穷尽式排查 (rule-out everything / 防御性医疗 / VOMIT)』; 『临床 gestalt ⇄ 结构化临床决策规则 (Wells/PERC/HEART)』; 『诊断简约 Occam's razor ⇄ Hickam's dictum (病人可以同时得 N 个病)』; 『床旁体格检查复兴 (Verghese Stanford 25 / McGee 循证体检) ⇄ 影像检验替代床旁』; (b) 方法论正典 — illness script theory (Schmidt/Boshuizen: enabling conditions/fault/consequences 三段结构), problem representation + semantic qualifiers 问题表征与语义限定词 (Bowen NEJM 2006, 把病人翻成 one-liner), hypothetico-deductive model (Elstein 1978《Medical Problem Solving》: 早期假设生成+定向检验), Bayesian 工具箱 (sensitivity/specificity/LR/Fagan nomogram/SnNout-SpPin), threshold model (Pauker-Kassirer NEJM 1975/1980), 认知偏倚分类学 (anchoring/premature closure/availability/confirmation/base-rate neglect/search satisficing/diagnostic momentum — Croskerry 偏倚清单), 去偏与元认知策略 (diagnostic timeout/cognitive forcing/Ely checklist/calibration), schema-based reasoning (Clinical Problem Solvers schemas: 按 pivot 症状走分支), reflective practice 结构化反思 (Mamede/Schmidt), 诊断错误科学 (NAM 2015 报告定义 / Newman-Toker Big Three / Hardeep Singh e-triggers / SAFER Dx 框架); (c) 行业结构与角色 — 医学生→实习/住院医 (晨会 morning report/查房被 pimping/汇报训练)→主治 attending→master clinician (NEJM CPC discussant/晨会大师如 Dhaliwal); 配套生态: 医学教育者 (clinical reasoning curriculum + 评估: script concordance test/key features exam/OSCE), 诊断安全研究者 (SIDM/AHRQ), 诊断辅助与 CDS 工具开发者 (DDx generator/AI); (d) 核心工作流 — 数据采集 (病史为王 + 循证体检 + 针对性检验影像) → 问题表征 (one-liner + semantic qualifiers) → 鉴别诊断生成 (schema / 解剖定位法 / VINDICATE-M 病因筛, 按『常见可能 × 致命不能漏 can't-miss』双轴排序) → 假设定向检验 (按 LR 选检查 / 阈值决策) → working diagnosis + 安全网 (red flags 交代 / test of time / test of treatment) → 反馈校准 (follow-up / M&M / diagnostic timeout); 教学工作流: 晨会渐进披露汇报 / CPC / SNAPPS / one-minute preceptor / virtual morning report; AI 增强工作流 (2023-2026: LLM 鉴别诊断头脑风暴 / OpenEvidence 检索 / ambient scribe 释放认知带宽 + 自动化偏倚 guardrails); (e) 产出物 — one-liner, problem list, prioritized DDx, assessment & plan (按问题分层), 晨会/CPC 汇报, M&M 复盘, 诊断不确定性沟通 (『最可能是 X, 但出现 Y 红旗立刻回来』); (f) 教育与评估 — script concordance test / key feature exam / EPA / 里程碑; 中国语境: 人卫《诊断学》教材 / 执业医师考试 / 规培结业临床思维考核; (g) 争议/批判 — debiasing 之争 (Croskerry vs Norman-Sherbino『knowledge is the cure』, 去偏 RCT 效果弱 / bias 标签不可证伪), 诊断错误率数字之争 (『10-15%』经典估计 / Newman-Toker 79.5 万美国年严重伤害外推方法被质疑 / 尸检符合率), dual-process 二分被批过度简化 (连续谱 / 难以实证分离), 决策规则 vs gestalt (资深 gestalt 常不输 Wells 类规则 / 算法厌恶), vignette 研究外推性 + context/case specificity (推理高度内容绑定不可通用迁移 [Norman/Eva] — 对『教推理通用课』产业的根本批判), AI 辅助诊断 2023-2026 (GPT-4 在 NEJM CPC/vignette 追平或超医生 [Kanjee 2023 JAMA / Goh 2024 JAMA Netw Open『AI alone > physician+AI』悖论] / Google AMIE / OpenEvidence 爆发 vs 自动化偏倚 / 去技能化 / 真实环境验证缺失), 防御性医疗与过度检查 (incidentaloma 瀑布 / VOMIT), 体检衰亡之争, pimping 教学法争议; (h) 流派/思想谱系 — 决策科学/Bayesian 派 (Ledley-Lusted 1959 → Elstein/Kassirer/Sox/Pauker/Eddy → Brush) vs 认知心理/双过程派 (Kahneman-Tversky → Croskerry/Graber) vs 教育认知派 (Schmidt/Boshuizen illness scripts → Norman/Eva/Mamede/Durning 情境认知) vs 诊断安全/系统派 (NAM 2015 / Newman-Toker / Hardeep Singh / Graber-SIDM: 错误=系统×认知共因) vs 床旁临床派 (Osler 传统 → Tierney aphorisms / Verghese / McGee / Dhaliwal / Saint: 病史体检为王 + 刻意练习) vs AI/计算派 (INTERNIST-1/DXplain 专家系统 → Isabel → LLM 世代 Rodman/Topol)。不含: 具体专科治疗方案与手术决策深度 (足踝外科/种植牙等另有 skill), 中医辨证 (另有 skill), EBM 文献批判性评价方法学 (相关但本 skill 聚焦诊断推理本身), 护理诊断体系 (NANDA), 影像/病理知觉型读片训练 (相邻但独立), 精神科 DSM 结构化访谈细节, 医患沟通技巧全集 (只覆盖诊断不确定性沟通), 患者自查/自我诊断指

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Helps users set up and run MobiZen-GUI to perform mobile-use tasks — automating Android phone operations via natural language. Use when the user wants to control a phone, execute mobile-use tasks, install/configure MobiZen-GUI, deploy MobiZen-GUI-4B model, or customize the agent's input/output. Triggers on keywords like phone task, mobile-use, mobile automation, Android control, MobiZen, ADB, deploy model, run agent, configure model.

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Turn a set of structures into absorption, distribution, metabolism, excretion, and toxicity estimates with ADMET-AI, and read them as a developability verdict rather than a table of numbers. Use this skill to run batch prediction over a library, interpret each endpoint against its DrugBank-approved percentile, and flag the liabilities that stop a series — hERG blockade, CYP inhibition, poor Caco-2 permeability, high clearance, and plasma protein binding. Also trigger on ADMET-AI, admet_ai, Chemprop-RDKit, hERG liability, CYP3A4 inhibition, Caco-2, bioavailability prediction, or developability triage.

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Analyzes Google Cloud BigQuery slot consumption, query costs, and execution bottlenecks using INFORMATION_SCHEMA. Use when diagnosing slow BigQuery queries, slot starvation, high on-demand query costs, unpartitioned table scans, or join performance issues. Don't use for generic BigQuery administration (use bigquery-basics), BigQuery ML (use bigquery-ai-ml), or DataFrame operations (use bigquery-bigframes).

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Remediation only — repair web accessibility (a11y) violations against WCAG 2.2 with a baseline, edit, and verify loop. Takes a target (URL, files, directory) or a findings worklist from `accessibility-scan`/`accessibility-inspect`/`accessibility-audit`, applies mechanical fixes as given, leaves TODOs for visual or contextual judgment, and verifies by re-running the baseline check. It only fixes. To find issues use `accessibility-scan` (one page, automated), `accessibility-inspect` (one page, manual), or `accessibility-audit` (whole site, WCAG-EM); to check for regressions use `accessibility-diff`. Use it for 'fix the a11y issues in X', 'make this accessible', 'add missing alt text and labels', 'apply these accessibility fixes', 'remediate these violations'.

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Expert-level microbiology covering bacterial and viral biology, microbial physiology, pathogenesis, antimicrobial resistance, microbiome science, and industrial microbiology.

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Knowledge base from FAA-HDBK-006D (2020), the FAA's System Reliability, Maintainability, and Availability (RMA) Handbook for National Airspace System (NAS) hardware and software. Use for RMA figures of merit (MTBF, MTBO, MTTR, the availability variants), the bathtub curve and probability distributions, the four-stage RMA lifecycle mapped to the FAA Acquisition Management System (AMS), the six-task RMA technical-management/acquisition process, service-thread criticality and the NAS-RD severity-to-target table, the RMA analysis toolbox (RBD, FMEA/FMECA, FTA, Ishikawa, Monte Carlo, Bayesian, FRACAS, ALT, reliability-growth/recovery tests), software reliability (early prediction + reliability growth), and tailorable example RMA requirements for a Program Requirements Document. Scope limits: it is FAA/NAS-specific guidance (not a requirement, by its own statement), centred on hardware-plus-software availability — it brackets out human/service/facility/communications availability, names but does not reproduce the math derivations or external standards (MIL-STDs, IEEE 1633, RTCA DO-178C/DO-278A, SAE JA1011), is thin on detailed worked numerical examples and on safety-case method, and predates any current revision beyond 006D.

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Estimates time-scaled phylogenies, molecular clock rates, effective reproduction number R_e (or R_t), and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict / uncorrelated lognormal / ORC clocks; constant / exponential / Bayesian Skyline / Skygrid / BICEPS / Birth-Death-Skyline / sampled-ancestor BDSKY priors; structured coalescent via MASCOT). Covers root-to-tip clock signal QC via TempEst, date-randomisation tests (Ramsden 2009; Duchêne 2015), recombination masking via Gubbins and ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction (Volz & Frost 2014; preferential-sampling extensions), MASCOT structured coalescent for migration, BICEPS-vs-BSP skyline choice, multi-chain BEAST2 convergence diagnostics, and reconciliation between phylodynamic R_e and case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline (Stadler 2013) models, diagnosing temporal-signal failure, masking recombination before clock inference for *Streptococcus pneumoniae* / *Neisseria gonorrhoeae* / *Klebsiella* / *E. coli* phylodynamics, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.

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Conducts penetration testing of iOS and Android mobile applications following the OWASP Mobile Application Security Testing Guide (MASTG) to identify vulnerabilities in data storage, network communication, authentication, cryptography, and platform-specific security controls. The tester performs static analysis of application binaries, dynamic analysis at runtime, and API security testing to evaluate the complete mobile attack surface. Activates for requests involving mobile app pentest, iOS security assessment, Android security testing, or OWASP MASTG assessment.

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Handle files and binary data in n8n correctly. Use when working with files, images, PDFs, attachments, uploads or downloads, base64, vision/multimodal input, or when an AI agent needs a file as tool input or output — and whenever the user mentions $binary, binaryPropertyName, "read the PDF", "attach the file", "send the image", Merge losing binary, or a CDN for chat images. Covers the $binary vs $json split, reading/writing binary, keeping binary alive across transforms with Merge, the agent-tool binary boundary, and the CDN/URL requirement for chat surfaces.

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Analyzes the downstream impact (blast radius) using data lineage on Google Cloud when a BigQuery table or view is broken, stale, or modified. Identifies all downstream tables, dashboards, and processes that will be affected. Use when: - Performing a blast radius or impact analysis for a BigQuery table or view. - Assessing the consequences of modifying, deleting, or pausing updates to a BigQuery asset. - Identifying downstream dependencies (tables, dashboards, processes) of a BigQuery asset. Don't use for: - General BigQuery querying or data analysis (use BigQuery-related tools instead). - Non-BigQuery assets (e.g., Cloud Storage files) unless they are part of the BigQuery lineage. - Creating or modifying lineage links directly.

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Handle files and binary data in n8n correctly. Use when working with files, images, PDFs, attachments, uploads or downloads, base64, vision/multimodal input, or when an AI agent needs a file as tool input or output — and whenever the user mentions $binary, binaryPropertyName, "read the PDF", "attach the file", "send the image", Merge losing binary, or a CDN for chat images. Covers the $binary vs $json split, reading/writing binary, keeping binary alive across transforms with Merge, the agent-tool binary boundary, and the CDN/URL requirement for chat surfaces.

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Plan, design, author, preview, publish, and manage Power BI reports across requirements, page design, local PBIR/PBIP edits, validation, screenshots, Fabric upload/download, and rebinding. Use for report lifecycle work; use semantic-model-authoring for model or DAX changes and fabriciq for data questions. Triggers: plan Power BI report, design report page, edit PBIR, preview PBIP, publish report, rebind report

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Assembles microbial-community sequencing into metagenome-assembled genomes (MAGs) with metaFlye (ONT), metaSPAdes/MEGAHIT (Illumina), and hifiasm-meta/metaMDBG (PacBio HiFi), then recovers genomes via multi-binner consolidation (MetaBAT2, MaxBin2, CONCOCT, SemiBin2, VAMB -> DAS_Tool) and QCs them against MIMAG with CheckM2, GUNC, and GTDB-Tk. Covers why a metagenome is not a genome (uneven coverage, micro-diversity, strain collapse to consensus), differential-coverage binning, co-assembly vs per-sample, the rRNA-operon collapse that fails short-read MAGs, and strain resolution with inStrain. Use when reconstructing genomes from a microbiome, soil, ocean, or gut community, recovering MAGs, or resolving strain-level variation.

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Bulk-query Ensembl BioMart (and other BioMart instances) for cross-database ID mapping, gene/transcript/exon coordinates, and ortholog tables. Use when batch-converting Ensembl IDs to other namespaces (HGNC, RefSeq, UniProt, Entrez), pulling gene coordinate tables for thousands of genes, building ortholog wide-tables across species, or replacing slow Ensembl REST loops with one-shot bulk export. Encodes BioMart's XML query format, R biomaRt vs Python pybiomart trade-off, mart-vs-dataset hierarchy, and the URL endpoint that's BioMart-specific (separate from rest.ensembl.org).

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Guidance for Power BI Project (PBIP) structure, thick and thin reports, project renames, forks, and validation. Use for .pbip, .pbism, .platform, definition.pbir, PBIP vs PBIX, or cross-cutting project operations.

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TOM and ADOMD.NET guidance via PowerShell for connecting to Power BI Desktop's local Analysis Services instance. Covers model enumeration, DAX queries, metadata modification, annotations, calendar definitions, field parameters, query tracing, DAX library package management (daxlib.org), and the Desktop Bridge for reloading and screenshotting the report canvas. Automatically invoke when the user mentions "Power BI Desktop", "Analysis Services port", "TOM", "ADOMD", "daxlib", "DAX library", "DAX UDF package", or asks to "connect to PBI Desktop", "query PBI Desktop with DAX", "modify PBI Desktop model", "add a measure to PBI", "capture visual queries", "create a field parameter", "validate DAX", "intercept DAX queries", "install daxlib", "add DAX SVG", "add IBCS", "reload the report canvas", "screenshot a report page", "Desktop Bridge", or to work with the model and report in Power BI Desktop together.

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Operational billing execution for legal matters. Monthly bill prep and billing instructions, LC invoice review and disbursement treatment, client billing query responses, cashflow modelling (LC payment obligations vs client receipts), and leverage and burn analysis (staffing mix, predicted total cost, margin trajectory). Trigger on: 'prepare the bill', 'billing instruction', 'end of month billing', 'LC invoice', 'local counsel invoice', 'pass through as disbursement', 'client querying the invoice', 'billing dispute', 'cashflow gap', 'when will we get paid', 'LC payment due', 'leverage analysis', 'staffing mix', 'predicted total cost', 'burn rate by grade', 'are we on track', 'what will this matter cost'.

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Precise knowledge on the binding sites of an RNA-binding protein (RBP) is key to understand (post-) transcriptional regulatory processes. Here we present a workflow that describes how exact binding sites can be defined from iCLIP data. The package provides functions for binding site definition and result visualization. For details please see the vignette.

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