「cma」の検索結果

Pharmacokinetic and pharmacodynamic modelling and simulation - non-compartmental analysis, compartmental and population PK, PK/PD and exposure-response, TMDD, PBPK orientation, bioequivalence, allometric scaling and first-in-human dose, drug interaction prediction, and Bayesian therapeutic drug monitoring. Use when analysing concentration-time data, deriving exposure metrics, fitting PK or PD models, or evaluating dosing regimens. Triggers include "pharmacokinetics", "pharmacodynamics", "PK/PD", "NCA", "non-compartmental", "AUC", "Cmax", "lambda z", "half-life", "clearance", "volume of distribution", "compartmental model", "population PK", "popPK", "NONMEM", "nlmixr2", "Pharmpy", "Monolix", "exposure-response", "Emax", "EC50", "indirect response", "effect compartment", "TMDD", "PBPK", "bioequivalence", "RSABE", "ABEL", "allometric scaling", "first-in-human", "MABEL", "drug-drug interaction", "DDI", "ICH M12", "concentration-QTc", "therapeutic drug monitoring", "MIPD", and "dosing regimen".

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Triage and resolve Arch Linux issues with pacman, systemd, and rolling-release best practices.

日本語の概要は準備中です。原文の説明を表示しています。

Phase 2 of building a Claude Managed Agent — turn a validated build sheet into exact API payloads and a resumable BYOK curl launch script, then launch (environment → agent → session → kickoff) using the founder's OWN Anthropic key. Use when the user says "launch it", "deploy the agent", "create the agent now", or when the orchestrator routes phase=stage-launch. payload_generator.py emits the four ordered payloads; launch_script_writer.py writes launch.sh that reads $ANTHROPIC_API_KEY at runtime and never embeds it; payload_validator.py runs a pre-launch check including an API-key-leak scan. No tool in this skill makes network calls — the user runs launch.sh themselves. Distinct from interview (planning) and grade-iterate (the outcome loop).

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Phase 4 of building a Claude Managed Agent — make it run without you. Turn a graded agent into a recurring scheduled deployment (POSIX-cron), an event-driven curl trigger, or confirmed on-demand use, then finalize the versioned roadmap. Use when the user says "run it every morning", "put it on a schedule", "nightly", "weekly", "automate this", "make it recurring", or when the orchestrator routes phase=run-without-you. deployment_builder.py builds the POST /v1/deployments payload (initial_events must include user.message; optionally nests a user.define_outcome so each firing self-grades); cron_validator.py validates the 5-field cron + IANA timezone and prints the wall-clock DST note; next_directions_writer.py writes NEXT-DIRECTIONS.md. No tool makes API calls — the deployment is created via BYOK curl. Distinct from grade-iterate (the in-session loop) and wrap-up (closeout).

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Close out a launched Claude Managed Agent — recap every primitive the founder now owns, regenerate the single-file overview page, and suggest the next 1-2 upgrades. Use when the user says "wrap up", "close this out", "what do I own now", "give me the summary", "recap the agent", or when the orchestrator routes phase=wrap-up. primitives_inventory.py tables everything owned (agent, environment, session, memory, outcome, deployment); overview_page.py regenerates a self-contained ./my-agent/agent-overview.html; upgrade_suggester.py ranks the next moves from recorded deferrals plus standing hardening steps. Companion to run-without-you; the last stop before phase=done.

日本語の概要は準備中です。原文の説明を表示しています。

Cooks and packages a shippable CARLA server from a UE 5.8 ue58-dev checkout via the CMake `package` targets (shipping/development/debug/test), scoping the cook with CARLA_MAPS_TO_COOK, and inspects an existing package for the failures a green build hides — stale pak/ucas mismatch, missing staged OpenDrive/TM road data, missing post-process profiles, and Town15's uncookable content. Use when the user asks to "package CARLA UE5", "cook a map", "build a shipping server", "make a distributable CARLA", or a package builds but renders black / has no maps.

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Writes, optimizes, and debugs C++ applications using modern C++20/23 features, template metaprogramming, and high-performance systems techniques. Use when building or refactoring C++ code requiring concepts, ranges, coroutines, SIMD optimization, or careful memory management — or when addressing performance bottlenecks, concurrency issues, and build system configuration with CMake.

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Guide for modernizing and migrating MSBuild project files to SDK-style format. USE FOR: converting legacy .csproj/.vbproj with verbose XML to SDK-style, migrating packages.config to PackageReference, removing Properties/AssemblyInfo.cs in favor of auto-generation, eliminating explicit Compile Include lists via implicit globbing, consolidating shared settings into Directory.Build.props. Indicators of legacy projects: ToolsVersion attribute, an Import of Microsoft.CSharp.targets via $(MSBuildToolsPath), .csproj files over 50 lines for simple projects. DO NOT USE FOR: projects already in SDK-style format, non-.NET build systems (npm, Maven, CMake), .NET Framework projects that cannot move to SDK-style.

日本語の概要は準備中です。原文の説明を表示しています。

Generate MSBuild binary logs (binlogs) for build diagnostics and analysis. USE FOR: adding /bl:{} to any dotnet build, test, pack, publish, or restore command to capture a full build execution trace, prerequisite for binlog-failure-analysis and build-perf-diagnostics skills, enabling post-build investigation of errors or performance. Requires MSBuild 17.8+ / .NET 8 SDK+ for {} placeholder; PowerShell must quote the complete switch as '-bl:{}'. DO NOT USE FOR: non-MSBuild build systems (npm, Maven, CMake), analyzing an existing binlog (use binlog-failure-analysis instead).

日本語の概要は準備中です。原文の説明を表示しています。

Build Holoscan SDK from source via the in-tree ./run script. Use only when published packages don't meet the user's needs.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill for MolMIM, NVIDIA's BioNeMo NIM microservice for small-molecule latent-space generation and optimization. Invoke for MolMIM, molecular embeddings, hidden states, latent decoding, sampling around a seed SMILES, CMA-ES guided molecule generation, QED or plogP optimization, hosted NVIDIA API calls, or local Docker deployment.

日本語の概要は準備中です。原文の説明を表示しています。

Retro arcade-inspired design with pixel fonts, dotted borders, playful high-contrast colors, and 8-bit game aesthetics.

日本語の概要は準備中です。原文の説明を表示しています。

Diagnoses and resolves Amazon RDS for Oracle connectivity, authentication, networking, and driver troubleshooting. Applicable to any RDS-for-Oracle question including connecting a Python Lambda to RDS Oracle in a VPC with pooling and cold-start optimization, EKS pods to RDS Oracle via the Secrets Manager CSI driver with IRSA and SecretProviderClass, ORA-12170 cross-VPC timeouts from EC2, DPI-1047 cannot-locate-64-bit-Oracle-Client errors, and Oracle Connection Manager (CMAN) on EC2 as a proxy with HA across two AZs. Covers python-oracledb thin vs thick mode, init_oracle_client, RDS Proxy does NOT support RDS Oracle, port 1521, VPC peering, Transit Gateway, Kerberos with AWS Managed Microsoft AD, SSL/TLS/NNE, SSM port forwarding, EC2/ECS Fargate/EKS/Lambda, SQL Developer/DBeaver/Toad/SQLcl, and Secrets Manager.

日本語の概要は準備中です。原文の説明を表示しています。

Prepare and run XQUIC local compilation. Use when asked to compile, build, configure, or diagnose the local build environment for XQUIC, especially across macOS/Linux. Detect intent and platform, then delegate actual compilation to scripts/validate.sh instead of hand-writing CMake commands.

日本語の概要は準備中です。原文の説明を表示しています。

Light and shade a three.js scene: choose materials (MeshStandardMaterial PBR vs unlit MeshBasicMaterial), add ambient/hemisphere/directional/point/spot lights, turn on shadow maps, and use an environment map (IBL) for realistic reflections. Use when a three.js model looks black, flat, or wrong — when the user mentions three.js materials, MeshStandardMaterial, lights, shadows, envMap, or PBR. For renderer/loop setup use threejs-scene-setup; for loading models use threejs-gltf-loading.

日本語の概要は準備中です。原文の説明を表示しています。

Decompose total effects into direct and indirect paths through mediators using mediation, CMAverse 4-way, HIMA/HIMA2 high-dimensional, BAMA, two-step / MVMR mediation, or double-ML medDML. Use when testing whether a molecular phenotype (expression, methylation, protein) mediates a treatment-outcome relationship, decomposing exposure-mediator interaction via VanderWeele 4-way, screening high-dimensional EWAS mediators, or running MR-based mediation when sequential ignorability is implausible.

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Expertise complète en droit français des étrangers, de l'asile et de la nationalité — entrée et visas, séjour (CESEDA livre IV, AES, étranger malade, regroupement familial, métiers en tension), éloignement et contentieux (OQTF, IRTF, rétention, référés, TA/CAA/CE), asile (OFPRA, CNDA, Dublin, CMA/ADA), nationalité et droits sociaux des étrangers (AME, PUMa, RSA, AAH, ASPA). Interroge en priorité trois connecteurs MCP complémentaires — OpenLegi (textes, jurisprudence administrative), LibreJustice (recherche sémantique tous ordres) et Legal Data Hunter (rétention/JLD, graphe de citations, statut de validité) — puis les sources officielles (Légifrance, ANEF, OFPRA, CNDA) et la doctrine associative (GISTI, Cimade, ADDE, Comede, Anafé). Déclencher dès qu'une question porte sur un étranger en France, même sans vocabulaire juridique — « papier de la préfecture », « récépissé périmé », « la CAF refuse le RSA » — et pour toute consultation, recours, note ou vérification de références dans ces matières.

日本語の概要は準備中です。原文の説明を表示しています。

Generate MSBuild binary logs (binlogs) for build diagnostics and analysis. USE FOR: adding /bl:{} to any dotnet build, test, pack, publish, or restore command to capture a full build execution trace, prerequisite for binlog-failure-analysis and build-perf-diagnostics skills, enabling post-build investigation of errors or performance. Requires MSBuild 17.8+ / .NET 8 SDK+ for {} placeholder; PowerShell must quote the complete switch as '-bl:{}'. DO NOT USE FOR: non-MSBuild build systems (npm, Maven, CMake), analyzing an existing binlog (use binlog-failure-analysis instead).

日本語の概要は準備中です。原文の説明を表示しています。

Guide for modernizing and migrating MSBuild project files to SDK-style format. USE FOR: converting legacy .csproj/.vbproj with verbose XML to SDK-style, migrating packages.config to PackageReference, removing Properties/AssemblyInfo.cs in favor of auto-generation, eliminating explicit Compile Include lists via implicit globbing, consolidating shared settings into Directory.Build.props. Indicators of legacy projects: ToolsVersion attribute, an Import of Microsoft.CSharp.targets via $(MSBuildToolsPath), .csproj files over 50 lines for simple projects. DO NOT USE FOR: projects already in SDK-style format, non-.NET build systems (npm, Maven, CMake), .NET Framework projects that cannot move to SDK-style.

日本語の概要は準備中です。原文の説明を表示しています。

Luamake 构建系统指南——用于当前项目的 `luamake` / `make.lua` / Ninja 生成流程。当用户需要编写、修改、排查或理解 `make.lua`、目标定义、`lm:conf`、`deps` / `objdeps`、代码生成、Lua C 模块、Bee 运行时集成，或需要解决当前项目中由 `luamake` 驱动的构建问题时，使用此 skill。即使用户没有明确提到 `luamake`，但上下文明显是在处理本项目的构建脚本、构建目录、目标依赖或 `luamake` 生成的 Ninja 流程，也应使用此 skill。不要把它用于纯通用的 C/C++ 编译知识、与本项目无关的 CMake / xmake / Bazel / Meson 问题，或仅讨论编译器理论而未涉及 `luamake` / `make.lua` 的请求。

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Medical Geneticist. Use when a task calls for Medical Geneticist judgment. Reasons from pedigree priors, HPO phenotype match, and ACMG/ClinGen variant classification; integrates exome/genome, CMA, RNA splicing, NBS ACT pathways, Tier 3 carrier screening, SF v3.3, and CPIC pharmacogenomics while treating VUS overcall, CPM/NIPT discordance, mtDNA heteroplasmy sampling, and SpliceAI-only splicing claims as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Cryptographer. Use when a task calls for Cryptographer judgment. Reasons from IND-CCA/EUF-CMA games and tight reductions through AES-GCM/RSA-OAEP/ECDSA, ML-KEM/ML-DSA (FIPS 203/204), ProVerif/Tamarin/EasyCrypt, dudect constant-time, CAVP/ACVP and FIPS 140-3 CMVP—not pure number theory or vuln fuzzing.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Air Quality Scientist. Use when a task calls for Air Quality Scientist judgment. Reasons from source emissions through transformation, transport, and dose using SMOKE/MOVES inventories, WRF-driven CTMs like CMAQ and CAMx, PMF/ME-2 apportionment, and concentration-response functions, while treating rotational PMF ambiguity, AOD-to-PM bias in humid regions, uncalibrated low-cost sensors, and untreated wildfire exceptional events as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。

Think and work like an expert Atmospheric Chemist. Use when a task calls for Atmospheric Chemist judgment. Reasons from coupled photochemical OH-NOx-VOC radical budgets, heterogeneous aerosol uptake, and NOx-limited versus VOC-limited regimes through MCM/F0AM and GEOS-Chem/CMAQ/WRF-Chem models, OH-reactivity closure, PMF on AMS factors, HYSPLIT trajectories, and EKMA isopleths while treating chamber wall losses, instrument cross-sensitivities and inlet artifacts, and emission-inventory error as first-class failure modes.

日本語の概要は準備中です。原文の説明を表示しています。