「baseline」の検索結果

Visualize copy number profiles, segments, allele-specific tracks, and cohort patterns from CNVkit, GATK, ASCAT, FACETS, Sequenza, and other callers. Covers genome-wide and per-chromosome log2 scatter plots, B-allele-frequency/minor-allele-fraction tracks, ideograms, cohort heatmaps, circos views, and caller-native plots. Use when creating publication CNV figures, choosing which plot answers a given question, diagnosing a wrong diploid baseline visually, displaying loss of heterozygosity, or deciding what depth-only plots cannot reveal.

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Infer integer allele-specific copy number, tumor purity, and ploidy from tumor sequencing by jointly modeling read depth (logR) and B-allele frequency (BAF) with ASCAT, Sequenza, FACETS, PURPLE, and PureCN (tumor-only). Covers the purity-ploidy identifiability problem, the diploid-baseline (dipLogR) anchor, major/minor copy number, loss of heterozygosity, sunrise/contour fit diagnostics, and reconciliation of conflicting fits. Use when tumor analysis needs absolute copy number rather than relative log2, when estimating purity and ploidy, calling LOH or copy-neutral LOH, resolving whole-genome doubling, running tumor-only allele-specific calling, or choosing among ASCAT, Sequenza, FACETS, and PureCN.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Estimate SNP heritability and partition it across functional annotations, cell types, and loci from GWAS summary statistics or individual-level genotypes. Implements LDSC, stratified LDSC with the baseline-LD model, Finucane 2018 cell-type prioritization, LDAK SumHer, HDL, HESS local heritability, BOLT-REML, GCTA-GREML, graphREML, and Popcorn cross-population genetic correlation. Use when computing total h2_SNP from summary stats, partitioning heritability across functional categories, prioritizing trait-relevant tissues or cell types from ENCODE/Roadmap chromatin marks, reconciling LDSC vs LDAK enrichment estimates, computing local heritability with HESS, estimating genetic correlation between traits, or producing publication-grade enrichment with calibrated sensitivity to model assumptions.

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Reads, validates, and prepares CDISC SDTM and ADaM clinical trial data for analysis. Covers SDTM domain joins (DM, AE, EX, VS, LB, DS), ADaM architecture (ADSL, BDS, OCCDS, ADTTE) with traceability, treatment-emergent AE conventions, baseline derivation, SUPPQUAL/NSV handling, Define-XML 2.1, and Pinnacle 21 / CORE validation. Use when working with clinical trial datasets in CDISC SDTM/ADaM format, preparing analysis-ready data, or validating for regulatory submission.

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The watch-fix-rerun method for making an existing platform agent or automated process efficient and correct: baseline its ledger, run one unit yourself, fix the class behind every wasted call, rerun, record. Use when asked to improve, optimize, watch, or 'make efficient' an agent, a sandbox session, a sync job, or any recurring automated process.

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Validates animation durations, enforces typography scale, checks component accessibility, and prevents layout anti-patterns in Tailwind CSS projects. Use when building UI components, reviewing CSS utilities, styling React views, or enforcing design consistency.

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Запускает lightweight baseline verification для docs, OpenSpec, skills и live context этого репозитория.

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Pre-commit verification pipeline — static security scan, baseline-aware quality gates, independent reviewer subagent, and auto-fix loop. Use after code changes and before committing, pushing, or opening a PR.

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Systematic performance profiling and optimization methodology. Covers CPU profiling, memory profiling, heap analysis, goroutine/thread analysis, FlameGraph generation, latency profiling, database query profiling, network I/O profiling, and continuous performance regression detection. USE WHEN: investigating performance issues, optimizing slow code, reducing memory usage, diagnosing GC/CPU bottlenecks, finding N+1 queries, analyzing pprof/flamegraph output, or establishing a performance baseline. Triggers on "profiling", "performance analysis", "slow code", "flame graph", "pprof", "heap dump", "memory leak", "CPU spike", "bottleneck".

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Add moments of joy, personality, and surprise through success states, empty states, loading moments, hover details, and celebratory polish once the fundamentals already work. Use when the user wants delight, charm, personality, or memorable micro-interactions—not when the main need is baseline cleanup or stronger visual impact.

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Runs BenchmarkDotNet microbenchmarks. Setup, memory diagnosers, baselines, result analysis.

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Gates CI on perf regressions. Automated threshold alerts, baseline tracking, trend reports.

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Defines baseline C# conventions loaded first -- naming, file layout, style rules.

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Detect anomalies in DNP3 (Distributed Network Protocol 3) communications used in SCADA systems by monitoring for unauthorized control commands, firmware update attempts, protocol violations, and deviations from baseline traffic patterns using deep packet inspection and machine learning approaches.

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Detect command injection attacks against Modbus TCP/RTU protocol in ICS environments by monitoring for unauthorized write operations, anomalous function codes, malformed frames, and deviations from established communication baselines using ICS-aware IDS and protocol deep packet inspection.

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Detects insider data exfiltration by analyzing DLP policy violations, file access patterns, upload volume anomalies, and off-hours activity in endpoint and cloud logs. Uses pandas for behavioral analytics and statistical baselines. Use when investigating insider threats or building user behavior analytics for data loss prevention.

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Implement User and Entity Behavior Analytics using Elasticsearch/OpenSearch to build behavioral baselines, calculate anomaly scores, perform peer group analysis, and detect insider threat indicators such as data exfiltration, privilege abuse, and unauthorized access patterns.

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This skill covers deploying anomaly detection systems for industrial control environments using machine learning models trained on OT network baselines, physics-based process models, and behavioral analysis of industrial protocol communications. It addresses building normal behavior profiles for SCADA polling patterns, detecting deviations in Modbus/DNP3/OPC UA traffic, identifying rogue devices, and correlating network anomalies with physical process data from historians.

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Detects anomalous authentication patterns using UEBA analytics, statistical baselines, and machine learning models to identify impossible travel, credential stuffing, brute force, password spraying, and compromised account behaviors across authentication logs. Activates for requests involving authentication anomaly detection, login behavior analysis, UEBA implementation, or suspicious sign-in investigation.

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Detect abnormal access patterns in AWS S3, GCS, and Azure Blob Storage by analyzing CloudTrail Data Events, GCS audit logs, and Azure Storage Analytics. Identifies after-hours bulk downloads, access from new IP addresses, unusual API calls (GetObject spikes), and potential data exfiltration using statistical baselines and time-series anomaly detection.

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Parse NetFlow v9 and IPFIX records to detect volumetric anomalies, port scanning, data exfiltration, and C2 beaconing patterns. Uses the Python netflow library to decode flow records, builds traffic baselines, and applies statistical analysis to identify flows with abnormal byte counts, connection durations, and periodic timing patterns.

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Optimize performance of the Adobe Dispatcher Apache HTTP Server module and related HTTPD configuration for AEMaaCS cloud workflows only, with cloud-specific baseline and runtime verification.

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Generates complete starter repositories for various tech stacks (Next.js, Vite, Nest, FastAPI, etc.) with best-practice conventions, folder structure, baseline code, configs, scripts, and setup documentation. Use when users request to "scaffold a project", "create a starter repo", "initialize a new project", or specify a tech stack to begin with.

日本語の概要は準備中です。原文の説明を表示しています。