「direction」の検索結果

Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instruments, or running sensitivity analyses for causal inference.

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Calculate contract-based futures position sizes from a direction, entry, and stop-loss, using verified per-symbol contract specs (multiplier, tick size, tick value). Use when the user asks how many futures contracts to trade, wants to size a futures position (ES, NQ, ZB, GC, CL, 6E/E6, VX, BT, ...), or is handing off a contrarian-setup-gate READY_FOR_PLAN direction/invalidation_level for sizing. Pure, offline calculation -- no API keys, no network.

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Applies a deliberate visual direction to an interface — minimalist editorial, industrial utilitarian, or high-polish commercial — each with its own type scale, palette behavior, surface treatment, and motion. Use this when a product needs a point of view rather than defaults, when choosing between visual directions, when an interface reads as generic, or when restyling something without changing its structure.

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Produces design reference imagery before implementation — screen concepts, layout directions, and flows for web or mobile that make a verbal brief concrete enough to argue with. Use this when a brief needs visualizing before anyone builds, when comparing layout directions, when handing a developer a target, or when stakeholders are describing different things with the same words.

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Scroll mouse wheel in specified direction. When you need to scroll page/document content, navigate long lists, or zoom in/out with Ctrl. Directions - up/down/left/right.

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Detect and correct for horizontal pleiotropy in Mendelian randomization analyses using MR-PRESSO for outlier removal, MR-Egger regression for directional pleiotropy, and Steiger filtering for variant directionality. Use when validating MR results, detecting pleiotropic instrum...

日本語の概要は準備中です。原文の説明を表示しています。

Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Colic et al. 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving greater sensitivity to small-effect hits than MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

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Implement, review, or improve maps and location features in iOS/macOS apps using MapKit and CoreLocation. Use when working with Map views, annotations, markers, polylines, user location tracking, geocoding, reverse geocoding, search/autocomplete, directions and routes, geofencing, region monitoring, CLLocationUpdate async streams, or location authorization flows. Also use when working with maps, coordinates, addresses, places, directions, distance calculations, or location-based features in Swift apps.

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Generate logo variants for a brand, producing multiple production-grade marks across different architectures (wordmark, lockup, symbol-only, letterform-as-symbol, monogram) with rationale, application specs, and decision-ready presentation. Distinct from `brand-identity`, which produces the complete system (logo plus color, type, voice, applications). Goes deep on the logo specifically: typographic register, symbol approach, application-context discipline (16px favicon, embroidery, signage, motion), and production specs (SVG-ready, single-color, reverse). Triggers on logo design, design a logo, wordmark, monogram, lockup, mark variants, logo iterations, redesign or refine the logo, logo refresh, letterform-as-symbol, and exploring mark variants for an established brand. Does NOT fire for full brand identity (use `brand-identity`), positioning or strategy (use `brand-discovery`), project-wide creative direction (use `creative-direction`), or one-off illustration.

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Design or evaluate a brand visual identity system covering logo, color, typography, imagery direction, iconography, and motion principles. Use this skill whenever the user wants to design a logo, build a visual identity, define brand colors, choose brand typography, develop iconography, plan brand imagery, or evaluate an existing identity for cohesion. Triggers on logo design, brand identity, visual identity, brand mark, wordmark, monogram, color palette, brand colors, brand typography, type system, iconography, brand imagery, motion design, brand system, identity system. Also triggers when the user has a brand direction approved and now needs the visual artifacts that express it.

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Create or refine a creative brief that bridges discovery and execution. Use this skill whenever the user is starting a new project, kicking off a website, beginning a brand build or redesign, briefing a designer or developer or AI agent, or trying to align a team before building. Triggers on creative brief, design brief, brand brief, project kickoff, kicking off, briefing the team, project intake, design direction, brief the designer, brief the dev, where do we start, how do we start, write a brief, project overview, scope this project, align on direction. Also triggers when the user has a vague idea and needs to make it concrete enough to hand off, even if they do not say 'brief' explicitly.

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Produce a creative brief grounded in live reference sites and deliberately distinct from existing demos, for any new brand build. Composes with brand-archetype-system and creative-direction. Use this skill at the start of any brand or microsite build when the result needs to land in a specific aesthetic position and not drift into a default house style. Triggers on creative brief, design brief, build brief, brand direction, where should this brand sit, what should this site look like, reference sites for, archetype for, distinct from our other brands, divergence from prior, not the same as. Also triggers when prior builds have come out as siblings and a systematic divergence approach is needed.

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Design game concepts from a novel. From SOURCE_BIBLE and PRODUCT_BRIEF, compare meaningful alternatives on the dimensions still unlocked, then select a playable direction using hard vetoes and explicit trade-offs. Use for what game should this novel become, compare game concepts, choose a game direction for this book, decide whether this novel should become an interactive story. 小说游戏概念设计。根据 SOURCE_BIBLE 与 PRODUCT_BRIEF 比较未锁定维度上的有效替代方案，用硬否决和关键取舍选择可玩方向。用于判断小说适合做成什么游戏、该不该做成互动叙事、比较游戏方案等需求。

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Build a risk-matched whitebox or the approved production game for its target runtime. Turn GAME_DESIGN, and ART_DIRECTION when production begins, into a minimal BUILD_BRIEF and a runnable candidate that can be iterated with replayable evidence. Use for prototype the riskiest design question, implement the approved game design, or turn this design into a running game. 游戏构建执行。先按最大风险做白盒，或在正式生产时把批准后的 GAME_DESIGN 与 ART_DIRECTION 压缩成最小 BUILD_BRIEF，在目标运行环境中实现可运行候选并用可回放证据迭代。用于验证高风险设计问题、构建游戏原型或实现批准方案。

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Create a packaging design brief — structure, visual direction, hierarchy, materials, and unboxing experience. Use when the user says "packaging design", "packaging brief", "product packaging", "packaging direction", "label design", "packaging identity", "unboxing experience", "packaging look and feel", "brief my packaging designer", "packaging for my product", "packaging strategy", "retail packaging", "e-commerce packaging", "what should my packaging look like", or is briefing a designer, agency, or manufacturer on packaging requirements.

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Dung khi designer se lam TREN CANVA hoac Figma va can direction thao tac cu the — chon template base, thu tu thao tac, map tung element vao vi tri, luoi va khoang cach, mau va font lay tu brand kit, checklist export, viec nen va khong nen lam. Kich hoat khi user nhac 'brief Canva', 'huong dan lam tren Canva', 'direction Canva', 'template Canva', 'layout Canva', 'lam trong Figma', 'ban design chua ranh nen phai chi tay'. Khong dung cho — brief concept anh tinh khong gan cong cu thi dung skill 42-brief-hinh-anh; chuoi slide carousel thi dung skill 43-brief-carousel; quy dinh mau, font va logo cua thuong hieu thi dung skill 46-brand-guideline.

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Use when an editor or videographer needs production direction — beat-by-beat storyboard, footage to shoot, b-roll, text overlays, music and pacing, transitions, CTA end frame, and per-channel export specs. This is the EDIT instruction, not the spoken script. Trigger on 'video brief', 'editor brief', 'storyboard', 'brief for the video editor', 'how should this video be cut', 'we have the footage and no direction'. Also use when raw clips exist and nobody knows what the final should look like. Not for — the words said on camera, see `04-script-video-global`; briefing a creator to film their own, see `06-ugc-egc-brief-global`; resizing a finished video, see `50-asset-resize-global`.

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Use when you need framework-agnostic Hexagonal architecture guidance for Java projects - ports and adapters boundaries, application core independence, driving and driven adapters, dependency direction, infrastructure leakage detection, optional architecture tests, and evidence-backed remediation. This should trigger for requests such as Review Hexagonal architecture; Review ports and adapters boundaries; Enforce dependency direction; Add ArchUnit architecture tests; Detect infrastructure leakage in domain code; Improve ports and adapters boundaries. Part of Plinth Toolkit

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Create game-ready fixed-cell pixel-art character spritesheets from text concepts, reference images, or existing character art. Use when Codex needs to design, generate, clean up, validate, and package 2D game characters with native 32x32, 64x64, or 128x128 cells; 4-way or 8-way directions; idle, walk/run, jump, attack, archer, caster, or other animation strips; transparent GIF/WebP previews; and per-direction targeted regeneration.

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On-demand senior red-team lead advisor. Call at a decision point or obstacle to get wiki-grounded direction instead of hammering blindly. Dispatches a fresh RTL subagent that reads the engagement state + evidence + wiki and returns ranked directions with an explicit STOP. Use for "redteamlead", "RTL", "I'm stuck", "where do I go", "what next", "which vector", "should I keep hammering this".

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Use when a researcher is choosing, framing, refining, or stress-testing a research question, hypothesis, thesis topic, project idea, grant direction, paper angle, or stalled research direction.

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Develop art direction for image generation with curated style cards distilled from Open Image Prompts. Use when choosing or comparing visual directions, improving an existing generation prompt, or translating a subject, use case, or supplied image into a compact creative spec. Use img-gen-prompts for real archive examples, exact source prompts, or gallery browsing.

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Generate one Content-Derived Design direction from an HTML source, or let Auto choose the strongest direction. Use when the user says /reimagine-it generate, "redesign this page", "make it a landing page", "turn this into an infographic", names a token (all 17: webpage, infographic, svg, 3js, simulation, artistic, cinematic, dashboard, photography, landing, editorial, gradient, showcase, motion, glass, lookbook, particles), or wants a content-aware redesign instead of a mood board. CLI: npx reimagine-it --auto -i page.html -o out.html. Part of the reimagine-it Content-Derived Design suite.

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Analyzes CRISPR drug-modifier (chemogenomic) screens with drugZ (Li & Hart 2019 Genome Med), a bidirectional Z-score method that identifies synthetic-lethal sensitizing genes and resistance-conferring suppressor genes from vehicle vs drug comparisons. Covers vehicle-anchored design (not Day-0), the bidirectional Z math giving 2-3x sensitivity over MAGeCK / STARS / edgeR / RIGER on drug screens, per-gene sumZ and normZ, synth (sensitizer) vs supp (suppressor) FDR, multi-dose handling, integration with control sgRNAs, and comparison with MAGeCK MLE with dose covariate. Use when running a drug-modifier CRISPR screen, identifying sensitizing or resistance genes for a drug candidate, choosing drugZ vs MAGeCK MLE for chemogenomic analysis, troubleshooting low-effect drug screens where MAGeCK lacks sensitivity, or designing a drug-screen layout (vehicle vs drug arms).

日本語の概要は準備中です。原文の説明を表示しています。