537 件 ・ 関連度順
概要と使いどころ
Drafts U.S. corporate board-of-directors meeting minutes into formal, defensible records documenting valid corporate action and governance process. Triggers on board minutes, directors meeting record, board resolutions, quorum validation, motion and vote capture, corporate secretary records, governance drafting. Requires source materials such as agenda, attendance, bylaws, notices, reports, prior minutes, and resolutions.
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Drafts a board resolution authorizing voluntary corporate dissolution via unanimous written consent of directors. Covers Plan of Complete Liquidation adoption, shareholder approval directive, officer authorizations, and execution provisions. Use when initiating voluntary dissolution, preparing corporate wind-down records, or drafting pre-shareholder dissolution authority under state corporation law.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2024 bioRxiv; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Dependency-conflict resolution when a `fix` version bump fails — diagnose the peer-dep tree, find a compatible safe version set, propose package-manager overrides (`overrides`/`resolutions`/`replace`/`[patch]`), fall back to safe-harbour inline patching. Use when an upgrade is blocked by transitive constraints, a peer-dep conflict surfaces, or you need to override a vulnerable transitive without bumping the parent.
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plan artifact がある時のみ、plan 中の assumption / open question が実装で解消された証拠を diff・PR 本文と突合する evidence-sufficiency 観点。解消されないまま残った前提・未記録の新規 Unknown を検出する。plan 欠損時は発火しない（Pre-execution Gate）。plan 欠損でも PR 本文に前提が inline 列挙されていれば列挙分のみ部分評価し、計画 issue の bare 参照だけなら skip する
Balances Hi-C contact matrices (ICE via cooler.balance_cooler, KR/SCALE/VC context), computes distance-decay expected with cooltools (expected_cis per-diagonal P(s), expected_trans scalar), builds observed/expected (O/E) matrices, and diagnoses polymer state from the P(s) log-derivative. Covers the within-matrix-vs-cross-sample distinction (balancing is NOT a normalizer), the equal-visibility assumption that CNV/aneuploidy violates (use raw counts for copy-number), cis-only balancing, mad_max/blacklist masking before balancing, multiplicative cooler weights vs divisive juicer weights, and the resolution-vs-depth budget. Use when balancing a .cool/.mcool, computing expected or P(s), making O/E matrices for compartments/loops, deciding ICE vs KR vs SCALE, choosing a resolution for a given depth, or troubleshooting NaN/all-NaN balanced matrices; route cross-sample comparison to hic-differential.
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Detects focal chromatin loops (point interactions / corner-dots) in balanced Hi-C and Micro-C contact maps and aggregates/validates a loop set. Covers de-novo calling with cooltools dots (HiCCUPS-style 4-background local enrichment with lambda-chunked FDR), chromosight (template-correlation), and Mustache (scale-space blob detection); aggregate peak analysis (APA) via cooltools pileup for confirmation; the depth/resolution prerequisite (de-novo needs ~5-10kb resolution = hundreds of millions to billions of valid pairs); consensus across callers and convergent-CTCF support as validation; and differential loops via union anchors plus chromosight quantify. Use when calling chromatin loops or dots from a cooler, deciding whether a map is deep enough to call de-novo vs running APA on known CTCF/cohesin anchors, building an aggregate peak pileup, comparing loops across conditions, or validating loop calls. For HiChIP/PLAC-seq/PCHi-C protein-anchored data use FitHiChIP/MAPS, not dots.
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Detects A/B chromatin compartments from balanced Hi-C contact matrices via eigenvector decomposition of the distance-normalized, Pearson-correlated cis matrix with cooltools (eigs_cis), then orients (phases) the compartment eigenvector against a GC or gene-density track so the active (A) sign is not arbitrary. Covers the eigenvector-is-a-choice problem (per-arm view_df to remove the centromere gradient; picking the eigenvector by max correlation with activity, not by eigenvalue), GC phasing with bioframe.frac_gc, resolution choice (100kb-1Mb), saddle plots and saddle_strength for compartmentalization strength, the cohesin-loss-strengthens-compartments result, subcompartments (SNIPER/Calder/dcHiC), and cross-condition compartment switching. Use when calling A/B compartments, computing E1/eigenvectors, phasing the eigenvector, building saddle plots, choosing a compartment resolution, quantifying compartment strength, or comparing compartmentalization across conditions.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Analyzes alternative splicing from PacBio Iso-Seq (HiFi, Kinnex/MAS-Iso-seq) and Oxford Nanopore (direct cDNA, direct RNA, R10.4.1+) long-read RNA-seq with full-isoform resolution. Tools include FLAIR (correct/collapse/quantify/diffSplice for PacBio + ONT), IsoQuant (de-novo or annotation-guided isoform discovery 2024 SOTA), Bambu (annotation-aware Bayesian discovery + quantification with Novel Discovery Rate), SQANTI3/SQANTI-LR (isoform classification: FSM/ISM/NIC/NNC + artifact flags), rMATS-long (event calling on long-read isoforms), and minimap2 (-ax splice:hq for HiFi; -ax splice -k14 for ONT cDNA; add -uf only for direct RNA or stranded cDNA preps). Solves microexon detection, recursive splicing, complex multi-exon isoforms, and DTU without transcript-quantification uncertainty. Use when short-read AS limitations (anchor length, complex isoforms, microexons, recursive splicing, transcript ambiguity) demand full-isoform resolution.
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This skill should be used when the user wants to "synthesize two competing solutions without averaging", "resolve a design/value disagreement by lifting to a higher frame", "止揚 / アウフヘーベン", "矛盾を止揚", "独立案を統合", "平均化せず統合", "contradiction lift", "sublate competing designs", or has two good-but-divergent answers to the same question and wants a higher-order resolution (a selection mechanism) or an honest aporia — not a compromise. NOTE: Use this when two independent solutions diverge and you want to PRESERVE both truth-moments while lifting to a higher frame. Use devils-advocate to stress-test ONE proposal with an assigned opponent, strong-inference to find an unknown cause, and dialectic-loop to validate a claim against a real corpus.
在Python 2.7环境下解析Windows目录链接（Junction）或符号链接的真实物理路径。提供基于PyWin32 API和PyQt4/5 QProcess调用cmd命令的两种解决方案，解决os.path.realpath失效及输出解析问题。
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Skill manifest management for dotnet-harness. Tracks skill dependencies, conflicts, version compatibility, and provides validation and resolution tools. Triggers on: skill manifest, dependency resolution, skill compatibility, version conflicts, build manifest, validate dependencies.
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Skill manifest management for dotnet-agent-harness. Tracks skill dependencies, conflicts, version compatibility, and provides validation and resolution tools. Triggers on: skill manifest, dependency resolution, skill compatibility, version conflicts, build manifest, validate dependencies.
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Deep-dive offensive methodology for dependency confusion and namespace attacks across all major package ecosystems. Covers npm scope confusion exploiting the gap between public and private scoped packages and .npmrc misconfigurations where registry mappings fail to pin internal scopes exclusively. Addresses PyPI namespace attacks through --extra-index-url resolution ordering, NuGet feed priority exploitation when multiple package sources are configured without clear directives, Maven and Gradle repository ordering where artifact resolution traverses repositories sequentially, Go module proxy abuse through GOPROXY misconfiguration, Ruby gems namespace squatting, and Docker image tag confusion with unqualified image references. Provides complete proof-of-concept methodology using safe callbacks including DNS canary via interactsh or Burp Collaborator and HTTP beacon with no destructive payload. Covers reconnaissance techniques for discovering internal package names through GitHub repository analysis, error ...
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動画・音声をVideoDBに取り込み、発話や映像から場面を検索して切り抜きを作成。字幕や音声の追加、画面比率の変換、ライブ映像の通知設定も支援します。
工場の設備・人員・材料・納期を踏まえて生産順序を組み、段取り替えや工程間の負荷を調整し、設備故障や材料不足時の計画見直しを支援するスキル。
Improve image and screenshot quality by enhancing resolution, sharpness, and clarity for professional presentations and documentation.
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Improves the quality of images, especially screenshots, by enhancing resolution, sharpness, and clarity. Perfect for preparing images for presentations, documentation, or social media posts.
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Walk through a complete GAIA benchmark→submit flow — from key resolution through HAL-compatible package generation
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Advanced git workflows with branch management, conflict resolution, and PR lifecycle
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Synthesize research findings from memory into structured reports with evidence grading, contradiction resolution, and actionable recommendations
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Add a browser WebCodecs bug to the Remotion Mediabunny WebCodecs bugs docs page. Use when given a Chromium, WebKit, or Firefox issue URL that should be tracked in packages/docs/docs/mediabunny/webcodecs-bugs.mdx, especially when needing to look up the issue title, filing date, reporter, and resolution state before editing the MDX table.
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Resolves free-text scientific labels to ontology term IDs and validates existing CURIEs against the EBI Ontology Lookup Service (OLS4). Also looks up prefixes in Bioregistry, resolves compact identifiers via Identifiers.org, maps lab shorthand with ZOOMA, and builds Ontobee term pages. Use whenever an ontology identifier must be produced or checked - annotating tissue, cell type, disease, phenotype, assay, chemical, organism, sex, or developmental stage fields; preparing metadata for GEO, ENA, BioSamples, CELLxGENE, HCA, or ISA-Tab submission; auditing a metadata table of term IDs; checking whether a term is obsolete and what replaced it; or deciding HPO vs HP. Triggers include "ontology term", "ontology ID", "CURIE", "controlled vocabulary", "UBERON", "CL:", "MONDO", "HPO", "EFO", "ChEBI", "NCBITaxon", "GO term", "PATO", "Zooma", "Bioregistry", "Identifiers.org", "Ontobee", "annotate this tissue/cell type/disease", and any request to emit or verify an identifier shaped like PREFIX:0001234.
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