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概要と使いどころ
Use this skill for MolMIM, NVIDIA's BioNeMo NIM microservice for small-molecule latent-space generation and optimization. Invoke for MolMIM, molecular embeddings, hidden states, latent decoding, sampling around a seed SMILES, CMA-ES guided molecule generation, QED or plogP optimization, hosted NVIDIA API calls, or local Docker deployment.
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Design unbiased survey instruments — question wording, scales, and sampling — to measure attitudes at scale. Use when you need quantitative breadth. For behavioural experiments, use `a-b-test-design` (prototyping-testing).
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Configures AWS WAF to filter web traffic: creating web access control lists (web ACLs) on CloudFront, Application Load Balancers, API Gateway, and AppSync; AWS Managed Rules tuned in Count mode; rate-based rules for HTTP floods; IP set and geographic match rules; Bot Control (Common and Targeted); turning bot labels into a confidence signal; stripping spoofed inbound x-amzn-waf-* headers; recovering the real client IP behind a CDN; Fraud Control (account takeover and account creation fraud prevention); and logging and request sampling. Use when the user wants to protect a web application or API from common exploits, bots, credential stuffing, fake-account creation, or HTTP floods at the application layer (layer 7). Routes to the right per-task procedure in references. Do NOT use for L3/L4 DDoS protection (shieldadvanced skill), multi-account WAF rollout (firewallmanager skill), CloudFront configuration (cloudfront skill), or Route 53 health checks or records (route53 skill).
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Audit and score blog posts on a 5-category 100-point scoring system covering content quality, SEO optimization, E-E-A-T signals, technical elements, and AI citation readiness. Includes advisory editorial style diagnostics (sentence-length variation, configured phrase lists, vocabulary sampling) that never infer authorship or affect scoring. Supports export formats (markdown, JSON, table) and batch analysis with sorting. Generates prioritized recommendations (Critical/High/Medium/Low) with specific fixes. Works with any format (MDX, markdown, HTML, URL). Use when user says "analyze blog", "audit blog", "blog score", "check blog quality", "blog review", "rate this blog", "blog health check".
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Use this skill when writing analytical SQL over time-series data with the TimescaleDB Toolkit (timescaledb_toolkit extension) hyperfunctions: approximate percentiles, statistical summaries, time-weighted averages, counter/gauge rates, uptime/heartbeat tracking, state durations, OHLC candlesticks, approximate distinct counts, top-N, and downsampling. **Trigger when user asks to:** - Compute percentiles/medians/p95/p99 over large or rolled-up time-series data - Compute rates or deltas from monotonic counters (Prometheus-style) or gauges - Compute time-weighted averages or integrals over irregularly sampled data - Track uptime/downtime from heartbeats, or time spent in each state - Build OHLC/candlestick or VWAP data for financial ticks - Store re-aggregatable summaries in continuous aggregates (two-step aggregation, rollup) - Approximate COUNT DISTINCT, find top-N / most frequent values, or downsample for charts **Keywords:** timescaledb_toolkit, hyperfunctions, percentile_agg, uddsketch, tdigest, approx_percentile, stats_agg, time_weight, counter_agg, gauge_agg, heartbeat_agg, state_agg, candlestick_agg, hyperloglog, approx_count_distinct, min_n, max_n, mcv_agg, lttb, asap_smooth, rollup, two-step aggregation
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Data conditioning techniques for gravitational wave detector data. Use when preprocessing raw detector strain data before matched filtering, including high-pass filtering, resampling, removing filter wraparound artifacts, and estimating power spectral density (PSD). Works with PyCBC TimeSeries data.
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Use BEFORE reading any data file that could be large (CSV/TSV, Parquet, HDF5, FITS, NetCDF, NDJSON, genomics FASTQ/FASTA/VCF/BAM, GRIB, ROOT, or big text/simulation logs like VASP OUTCAR). Returns a compact memory pointer — header/schema/shape/sample/key numbers — by introspection and sampling in bounded memory, so you never load a file bigger than the context window into the model. Reference data via the pointer; read specific ranges deterministically.
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Generate ideas in one shot using creative sampling
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Draft a structured preregistration document (OSF, AsPredicted, or AEA RCT Registry style) from a research spec or free-form study description. Output is a Markdown file with hypotheses, design, sampling plan, analysis plan, exclusions, and inference criteria — annotated with MUST / SHOULD / MAY clarity flags. Use when user says "preregister", "draft a preregistration", "OSF preregistration", "AsPredicted", "AEA RCT registry", "PAP", "preanalysis plan", or before launching an experiment / data collection / analysis on data the analyst has not yet seen. NOT a registry submission tool — produces a document the user uploads to OSF / AsPredicted / AEA themselves.
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Create diverse synthetic test inputs for LLM pipeline evaluation using dimension-based tuple generation. Use when bootstrapping an eval dataset, when real user data is sparse, or when stress-testing specific failure hypotheses. Do NOT use when you already have 100+ representative real traces (use stratified sampling instead), or when the task is collecting production logs.
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Specify the tracing, metrics, and alerting for an AI agent or LLM feature in production. Use when asked what to log for an LLM app, design agent tracing or spans, define quality and cost monitors, or answer 'how do we know if the agent is misbehaving?'. Produces an observability spec with a trace schema, metric definitions with owners and alert thresholds, sampling and retention policy, and a privacy note for logged content.
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Tracks ctDNA across serial liquid-biopsy timepoints for molecular residual disease (MRD) and treatment-response monitoring, treating MRD as a binary integrated detection call across the patient's full variant set (with a defined LoD95 and per-sample specificity) rather than a per-timepoint VAF threshold, and handling undetectable samples as left-censored at the per-sample limit of detection rather than true zeros. Covers tumor-informed bespoke vs tumor-naive design, landmark vs surveillance sampling, molecular-response definitions and their non-standardization, censoring-aware clearance kinetics, and the multiple-testing structure of repeated surveillance. Use when monitoring ctDNA during therapy, calling molecular relapse before imaging, or estimating clearance half-life from serial samples.
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Treats a ctDNA assay as a molecule-counting experiment at the Poisson edge and builds its analytical-validation case the measurement-science way. Covers the genome-equivalent currency (~330 haploid copies/ng), the lambda = input_GE x VAF sampling ceiling (lambda>=3 for ~95% detection), the error-suppression ladder (raw NGS ~1e-3 -> single-strand UMI ~1e-4/1e-5 -> duplex <1e-7), the CLSI EP17 LoB/LoD/LoD95/LoQ framework, the per-locus-vs-panel-integrated LoD distinction that lets bespoke MRD reach ppm, contrived/SEQC2 reference standards, and honest LoD reporting conditioned on input mass + consensus depth + replicate detection rate. Use when stating or trusting a sensitivity claim, designing a dilution-series validation, deciding how many genome equivalents are needed at a target VAF, choosing a single-locus vs panel-integrated LoD, or auditing a "detects 0.1% VAF" claim.
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Estimates time-scaled phylogenies, molecular-clock rates, effective reproduction number R_e, and population dynamics from dated pathogen genomes using TreeTime (maximum-likelihood) and BEAST2 (Bayesian; strict/relaxed clocks; coalescent, Bayesian-Skyline, Skygrid, Birth-Death-Skyline, and sampled-ancestor priors; structured coalescent via MASCOT). Covers root-to-tip clock QC via TempEst, date-randomisation tests, recombination masking via Gubbins/ClonalFrameML before clock inference for recombining bacteria, BDSKY origin-vs-rootHeight pitfalls, sampling-bias correction, multi-chain convergence diagnostics, and reconciling phylodynamic R_e with case-based R_t. Use when dating outbreak origins, estimating substitution rates, inferring R_e through time, building time-calibrated Nextstrain Augur trees, choosing between strict and relaxed clocks, fitting Birth-Death-Skyline models, diagnosing temporal-signal failure, running MASCOT for structured-population analyses, or using UShER for pandemic-scale placement.
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Quantifies biodiversity from species abundance/incidence tables using Hill numbers (iNEXT) with coverage-based rarefaction-extrapolation (Chao & Jost 2012), asymptotic richness via Chao1/ACE/jackknife as a lower bound, Baselga turnover/nestedness partition with the Podani alternative as sensitivity check, mandatory Hellinger transformation before ordination (Legendre & Gallagher 2001), Faith PD and SES_MPD/SES_MNTD with explicit null-model choice, and Maire 2015 functional-diversity dimensionality optimization. Use when comparing diversity across sites with unequal sampling effort, picking the right richness estimator for singleton-heavy amplicon data, partitioning beta diversity into turnover vs nestedness, reporting Hill-number effective species counts rather than raw entropies, computing SES_MPD with explicit null-model justification, or deciding whether to apply standard metrics to compositional amplicon data. Not for clinical 16S microbiome diversity (see microbiome/diversity-analysis).
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Generates 3D conformer ensembles using RDKit ETKDGv3 with knowledge-enhanced distance geometry, MMFF94/UFF force-field optimization, CREST + GFN2-xTB semi-empirical refinement, and macrocycle-aware torsion preferences. Provides explicit decision rules for single vs ensemble conformer use, RMSD pruning, energy windows, conformer count, and force-field choice. Use when preparing 3D ligands for docking, generating descriptor input for 3D QSAR, or sampling macrocycle/peptide conformational ensembles.
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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.
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Best-practices reference for preparing and instrumenting applications on Temps. Covers the app runtime contract (`.temps.yaml` health, HOST/PORT, readiness, SIGTERM, replicas, migrations) and production observability (errors, traces, metrics, logs, analytics, privacy, sampling, cardinality, credential boundaries). Use whenever building or reviewing an app for Temps, configuring health checks, adding telemetry, diagnosing missing/noisy signals, or checking OTLP/Sentry/analytics ingestion. Triggers include "temps best practices", "prepare this app for Temps", ".temps.yaml health", "temps health check", "ignore health checks in otel", "temps observability", "wire up telemetry", and "instrument this app for temps". Prefer focused setup skills for a single SDK. Use temps-cli for executing deploy and resource-management commands.
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This package implements sampling, iteration, and input of FASTQ files. The package includes functions for filtering and trimming reads, and for generating a quality assessment report. Data are represented as DNAStringSet-derived objects, an
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A post hoc cell type classification tool to fine-tune cell type annotations generated by any cell type classification procedure with semi-supervised learning algorithm AdaSampling technique. The current version of scReClassify supports Support Vector Machine and Random Forest as a base classifier.
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Expert knowledge for Azure Microsoft Opentelemetry development including configuration. Use when setting sampling, exporters, resource attributes, env vars, or tuning tracing/metrics behavior, and other Azure Microsoft Opentelemetry related development tasks. Not for Azure Monitor (use azure-monitor).
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OpenTelemetry setup, span context propagation, sampling strategies, Jaeger queries
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Time-series database implementation for metrics, IoT, financial data, and observability backends. Use when building dashboards, monitoring systems, IoT platforms, or financial applications. Covers TimescaleDB (PostgreSQL), InfluxDB, ClickHouse, QuestDB, continuous aggregates, downsampling (LTTB), and retention policies.
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Use when you need to implement or improve distributed tracing with OpenTelemetry in Java — including trace/span modeling, context propagation, semantic conventions, span attributes/events/status, sampling strategy, baggage usage, privacy safeguards, and backend integration with OTLP collectors. This should trigger for requests such as Improve tracing; Apply OpenTelemetry tracing; Add distributed tracing; Refactor tracing instrumentation; Instrument Java services with OpenTelemetry spans. Part of Plinth Toolkit
日本語の概要は準備中です。原文の説明を表示しています。