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Prioritize drug targets from a ranked gene list (e.g., scRNA-seq DE output) by orchestrating parallel API queries against UniProt, OpenTargets (with integrated DepMap CRISPR essentiality + gnomAD constraint), PubMed, the Human Protein Atlas (HPA), and ChEMBL tool compounds, then re-ranking by a composite score combining protein localization, druggability, disease genetics, tissue specificity (safety), focus-cell-type expression, CRISPR essentiality, LoF safety constraint, and research maturity. Use whenever the user wants to filter, triage, prioritize, or "do due diligence" on a list of candidate genes for drug discovery, especially after a DE / DEG analysis when they say things like "which of these should I follow up on", "filter for druggable targets", "make a target dossier", "rank these for tractability", "annotate these genes for druggability", or "build a target report". Trigger even when the user says just "filter these candidate genes" or hands over a CSV from a DE pipeline.

日本語の概要は準備中です。原文の説明を表示しています。

GitHub OSS向け README.md の作成・改善・レビューを支援する。What/Why/How to start/Help/Maintainers の軸で情報を整理し、最短で動かせる Quickstart と docs への導線を構成する。 READMEの新規作成、既存READMEの再構成、READMEレビュー、ドキュメント分割の判断時に使用する。 トリガー：「READMEを作って」「READMEを改善して」「Quickstartを追加して」 「GitHub向けREADMEテンプレ」「READMEをレビューして」などのREADME関連リクエスト。

Use this skill when controlling the AltirraSDL Atari emulator programmatically — driving the simulator from a script, capturing screenshots from a running Atari, injecting joystick/keyboard input, frame-stepping for deterministic testing, reading or writing CPU/memory/chip state, setting breakpoints or watchpoints, profiling 6502 code, loading symbols, or building automated tests against an Atari binary. Triggers on phrases like "AltirraBridge", "AltirraSDL --bridge", "AltirraBridgeServer", "Altirra Python SDK", "headless Atari emulator", "screenshot the Atari", "automate AltirraSDL", "drive the emulator from Python", "Atari debugger over a socket", "altirra_bridge package", as well as on tasks involving the bridge protocol, the Python `altirra_bridge` package, or the C `altirra_bridge.h` SDK.

日本語の概要は準備中です。原文の説明を表示しています。

Consult this skill BEFORE proposing a fix to any CLI gap or schema gap that touches evidence, trust magnitude, evidence types, evidence grades, the TM formula, or star-level promotion gates. Also read it whenever an issue mentions citations, stars, commits, contributors, views, reviewers, percentile, arxiv, github-stars-own, repo-own, social-signal, benchmark-result, peer-review, self-attestation, fusion-recipe, verifier-attestation, or proxy-containment — those are the 10 canonical evidence types and the raw inputs that feed their formulas. Also read it when asked whether a skill qualifies for a given star level (0★–6★): the Star Bar and promotion gates live in `META.md`, not in the TM methodology page. Reading both prevents proposing a calibration that satisfies the TM grade threshold but violates a Star Bar installability or link requirement.

日本語の概要は準備中です。原文の説明を表示しています。

Auto-activate for litestar_saq, SAQPlugin, SAQConfig, QueueConfig, TaskQueues, CronJob, litestar workers run, background jobs, schedules, or SAQ UI. Not for litestar-queues, Celery, RQ, or Dramatiq.

日本語の概要は準備中です。原文の説明を表示しています。

Troubleshoot and debug LiveAvatar integration issues. Use when the user's LiveAvatar integration isn't working, the avatar is silent, audio is garbled, sessions fail to start, events aren't received, or they're getting API errors.

日本語の概要は準備中です。原文の説明を表示しています。

Collect and submit developer feedback to the LiveAvatar team. Use when: (1) A LiveAvatar integration is done, working, finished, or complete, (2) The user says "it works", "we're done", "that's it", "ship it", (3) The user is frustrated, stuck, or giving up — "this is broken", "this doesn't work", "I'm stuck", "I give up", "this is frustrating", "I want to report an issue", (4) The user explicitly asks to give feedback, report a bug, file an issue, or share a suggestion about LiveAvatar, (5) You've seen 3+ failed attempts at the same integration step, (6) You just finished writing or generating LiveAvatar integration code for the user.

日本語の概要は準備中です。原文の説明を表示しています。

Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

日本語の概要は準備中です。原文の説明を表示しています。

Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

日本語の概要は準備中です。原文の説明を表示しています。

Expert-level planetary science covering solar system formation, planetary interiors, atmospheres, surface processes, astrobiology, and planetary exploration missions.

日本語の概要は準備中です。原文の説明を表示しています。

Guide for organizing MSBuild infrastructure with Directory.Build.props, Directory.Build.targets, Directory.Packages.props, and Directory.Build.rsp. Only activate in MSBuild/.NET build context. USE FOR: structuring multi-project repos, centralizing build settings, implementing NuGet Central Package Management (CPM) with ManagePackageVersionsCentrally, consolidating duplicated properties across .csproj files, setting up multi-level Directory.Build hierarchy with GetPathOfFileAbove, understanding evaluation order (Directory.Build.props → SDK .props → .csproj → SDK .targets → Directory.Build.targets). Critical pitfall: $(TargetFramework) conditions in .props silently fail for single-targeting projects — must use .targets. DO NOT USE FOR: non-MSBuild build systems, migrating legacy projects to SDK-style (use msbuild-modernization), single-project solutions with no shared settings. INVOKES: no tools — pure knowledge skill.

日本語の概要は準備中です。原文の説明を表示しています。

Quantitative drug-target validation pipeline. Scores druggability, selectivity, safety profile, ADMET feasibility, and structural tractability with a composite Target Validation Score (0-100) and GO/NO-GO recommendation. Use for go/no-go decisions on a target before commit-to-medchem, target prioritization across a list, and target-deselection rationale.

日本語の概要は準備中です。原文の説明を表示しています。

Official HeyGen plugin for OpenClaw — adds HeyGen as a first-class provider for the built-in video_generate tool. Identity-first avatar videos: pick an avatar_id, a voice, a script, and get an on-brand presenter video back. Use when: (1) generating a video where a specific avatar/person speaks specific lines, (2) "make a video of me / our brand presenter", (3) outreach, announcements, pitch decks, product walkthroughs, or any presenter-led video, (4) needing landscape or portrait output with deterministic aspect ratios, (5) integrating HeyGen into an OpenClaw agent through the standard provider interface (no bespoke REST glue required). Covers: HeyGen v3 Video Agent (api.heygen.com), avatar-presenter video, identity-preserving video, talking-head AI video, scripted avatar narration, brand spokesperson video. NOT for: cinematic b-roll (use Veo / Runway / Kling), video translation, TTS-only, streaming avatars, or photo-to-talking-head v2 pipelines.

日本語の概要は準備中です。原文の説明を表示しています。

Identify direct miRNA-target interactions from AGO HITS-CLIP, AGO-CLEAR-CLIP (chimeric reads), HEAP (Halo-Ago2 mouse), chimeric eCLIP / miR-eCLIP (deep miRNA-target profiling), or CLASH using chimeric-read processing pipelines, seed-pairing analysis, and 3' auxiliary pairing rules. Use when distinguishing direct miRNA targets from indirect, integrating CLIP-derived target maps with TargetScan / miRDB / DIANA predictions, applying canonical 7mer-8mer seed matching with 3' UTR context, or recovering miRNA-mRNA chimeras at scale.

日本語の概要は準備中です。原文の説明を表示しています。

Runs cis-pQTL Mendelian randomization for drug-target validation using UKB-PPP (Olink), deCODE (SomaScan), Fenland, INTERVAL, ARIC, and FinnGen-PPP proteomes plus colocalization triangulation, phenome-wide on-target adverse-effect scans, cross-platform Olink/SomaScan replication, and PAV (protein-altering variant) sensitivity. Use when nominating or de-risking a drug target from plasma-proteome GWAS, mimicking pharmacological inhibition via cis-pQTL instruments, separating shared-causal from LD-confounded signal under the Schmidt 2020 cis-MR framework, screening on-target adverse phenotypes pheWAS-style, or producing publication-grade STROBE-MR plus PP.H4 evidence for a target gene.

日本語の概要は準備中です。原文の説明を表示しています。

XとLinkedInのつながりから、会いたい相手への紹介経路を評価するスキル。経路の近さや関係の強さを重み付けし、紹介を頼む候補と接点の不足を整理します。

• 対象者を紹介できる知人探し
• 共通の知人を紹介価値で順位付け
• 対象企業への紹介経路を調べたいとき

Claude Codeの作業状況や決定事項、次の手順をプロジェクト別に保存するスキル。別のセッションでも概要を読み込み、前回の続きから作業を再開できます。

• 終了前に進捗と次の手順を保存
• 前回のセッションから再開したいとき
• 複数プロジェクトの状況確認

Retrieve a country's average applied tariff over time — the MFN rate on all products, or the rate it applies on goods from one partner and/or in one product group — plus the optional US effective tariff rate. Use when the user asks how a country's tariffs have changed, or what it charges another country on average. For one product between two countries, use lookup-bilateral-tariff.

日本語の概要は準備中です。原文の説明を表示しています。

Define a North Star Metric and 3-5 supporting input metrics that form a metrics constellation. Classify the business game (Attention, Transaction, Productivity) and validate against 7 criteria for an effective North Star. Use when choosing a North Star Metric, setting up a metrics framework, learning about the North Star Framework, or deciding what to measure.

日本語の概要は準備中です。原文の説明を表示しています。

House cold-start interview (request list + prior memo), or --new-deal for deal-specific context. Modular: identifies which practice areas apply (M&A, Board & Secretary, Public Company, Entity Management), then asks targeted questions for each active module and writes only the relevant sections to the plugin config. Use on fresh install, when CLAUDE.md still has [PLACEHOLDER] markers, when starting a new deal, or to re-check integrations or refresh a module.

日本語の概要は準備中です。原文の説明を表示しています。

Use when creating, refreshing, packaging, inspecting, promoting, or deprecating a named per-seat starting point — Agent Starter manifest authoring, the 6-state lifecycle (captured → named → inspectable → used → promoted → deprecated), provenance honesty, and refusal rules. NOT a VM image; a managed starting point composed from agent role + startup context + optional native session source + provenance.

日本語の概要は準備中です。原文の説明を表示しています。

Reference for building Starknet applications using starknet.js v9.x SDK, including contract interaction, account management, transaction handling, fee estimation, wallet integration, and paymaster flows.

日本語の概要は準備中です。原文の説明を表示しています。

Switch the active Jetson target-platform pointer to an existing profile YAML. Use before customize/build/flash to change target; not for authoring profiles — use jetson-init-target instead.

日本語の概要は準備中です。原文の説明を表示しています。

Query Open Targets Platform for target-disease associations, drug target discovery, tractability/safety data, genetics/omics evidence, known drugs, for therapeutic target identification.

日本語の概要は準備中です。原文の説明を表示しています。