「modeling」の検索結果

Fits structural equation models to GWAS summary statistics using GenomicSEM (Grotzinger 2019), including common-factor models, confirmatory factor models, ESEM, common-factor GWAS with Q_SNP heterogeneity, multivariate Wald tests, and stratified GenomicSEM partitioned heritability. Reconciles results against MTAG multi-trait analysis. Handles sample overlap via the LDSC sampling-covariance matrix, identifies and resolves Heywood cases, and verifies model fit with CFI / RMSEA. Use when modeling latent genetic architecture across correlated traits, running multivariate GWAS on a shared factor, distinguishing factor-mediated from trait-specific SNP effects, or comparing GenomicSEM common-factor results against MTAG when both depend on accurate sampling covariance.

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Builds and applies 3D pharmacophore models using RDKit Pharm3D, the apo2ph4 receptor-based workflow (Heider et al 2022/2023 J Chem Inf Model 63:147-158), Pharmer / Pharmit (search), and PharmacoForge (diffusion-based generation, Flynn et al 2025 Front Bioinform), covering ligand-based pharmacophore (from active set alignment) and receptor-based pharmacophore (from binding pocket geometry). Explicit handling of feature types, geometric tolerances, partial matching, and pharmacophore-based virtual screening. Use when identifying scaffold-hopping candidates, building shape-and-feature search queries, or transferring SAR across chemotypes.

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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.

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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.

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Calls ChIP-seq peaks with MACS3, MACS2, HOMER, or SPP across narrow (TF) and broad (histone) modes. Handles input control matching, fragment-size modeling vs --nomodel, effective genome size, ENCODE-style IDR vs naive overlap, hyper-ChIPable artifacts, and aligner-specific shifts. Use when calling peaks from ChIP-seq alignments, choosing between narrow vs broad mode for a histone mark, deciding model vs nomodel for low-depth data, applying ENCODE pseudoreplicate IDR, or reconciling MACS vs HOMER vs SPP results.

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Use when a carrier asks whether to buy or lease their next tractor (or trailer), comparing full-service lease (Ryder, Penske, NationaLease), capital lease, finance lease, walk-away open-end lease, or cash purchase. Covers tax treatment, residual risk, maintenance bundling, balance-sheet impact, and cash-flow modeling.

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Use when a carrier asks how to calculate cost-per-mile (CPM) at the fleet, truck, lane, or driver level — separating fixed vs variable costs, allocating overhead, accounting for empty miles, and using CPM to negotiate rates, build pricing tiers, or evaluate lane profitability.

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This skill should be used when the user asks to "model agent mental states", "implement BDI architecture", "create belief-desire-intention models", "transform RDF to beliefs", "build cognitive agent", or mentions BDI ontology, mental state modeling, rational agency, or neuro-symbolic AI integration.

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Control Blender directly from Hermes via socket connection to the blender-mcp addon. Create 3D objects, materials, animations, and run arbitrary Blender Python (bpy) code. Use when user wants to create or modify anything in Blender.

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根据指定字段设计Couchbase订单文档模型（单桶策略），并生成包含引用完整性的N1QL插入语句。

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This skill provides an advanced financial modeling suite with DCF analysis, sensitivity testing, Monte Carlo simulations, and scenario planning for investment decisions

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归因模型设计——量化每个增长渠道的真实贡献，科学分配预算，优化LTV/CAC比。 覆盖：多渠道归因（单触点/多触点）、数据驱动归因（Google DDA）、概率归因、 马尔科夫链归因、U型/T型/时间衰减模型、Cohort分析、LTV预测、MTA/MMM方法论。 融合Google"数据驱动归因"(DDA)、Meta"多触点归因"、字节"增长数据闭环"、网飞"因果推断"。 触发词：归因分析、attribution、渠道分析、ROI分析、CAC计算、LTV计算、归因模型、 数据驱动归因、多渠道归因、漏斗归因、marketing mix、MTA、MMM、转化归因、渠道归因。

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Security review and threat work — threat modeling, vulnerability assessment, penetration test, incident response, OWASP Top 10, LLM Top 10, API Top 10, CVE triage, STRIDE, NIST CSF, SBOM. Auto-loops on any task touching PII, auth, payments or regulated data.

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Step-by-step guide for capturing key application requirements for NoSQL use-case and produce Azure Cosmos DB Data NoSQL Model design using best practices and common patterns, artifacts_produced: "cosmosdb_requirements.md" file and "cosmosdb_data_model.md" file

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建模资产支持证券交易结构，模拟抵押贷款池现金流、债券分级偿还和瀑布分配，分析 tranche 收益与风险表现。。

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Professional assistant for 3D printing, laser engraving, and 3D modeling workflows. Supports generating visual references for sculpting (Forger/ZBrush), creating 3D models via Meshy AI, and optimizing FDM/Resin print settings. Use when designing, fabricating, or troubleshooting physical maker projects.

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Build accretion/dilution (merger) models in Excel — pro-forma P&L, synergies, financing mix, EPS impact. Pairs with excel-author. Use for M&A pitches, board materials, or deal evaluation.

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Build leveraged buyout models in Excel — sources & uses, debt schedule, cash sweep, exit multiple, IRR/MOIC sensitivity. Pairs with excel-author. Use for PE screening, sponsor-case valuation, or illustrative LBO in a pitch.

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Build comparable company analysis in Excel — operating metrics, valuation multiples, statistical benchmarking vs peer sets. Pairs with excel-author. Use for public-company valuation, IPO pricing, sector benchmarking, or outlier detection.

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Control Blender directly from Hermes via socket connection to the blender-mcp addon. Create 3D objects, materials, animations, and run arbitrary Blender Python (bpy) code. Use when user wants to create or modify anything in Blender.

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Build institutional-quality DCF valuation models in Excel — revenue projections, FCF build, WACC, terminal value, Bear/Base/Bull scenarios, 5x5 sensitivity tables. Pairs with excel-author. Use for intrinsic-value equity analysis.

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Build auditable Excel workbooks headless with openpyxl — blue/black/green cell conventions, formulas over hardcodes, named ranges, balance checks, sensitivity tables. Use for financial models, audit outputs, reconciliations.

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Build fully-integrated 3-statement models (IS, BS, CF) in Excel with working capital schedules, D&A roll-forwards, debt schedule, and the plugs that make cash and retained earnings tie. Pairs with excel-author.

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Extract a DDD-style domain glossary from conversation context, choosing canonical terms and flagging ambiguity. Use when the user asks to define domain terms, build a glossary, clarify terminology, create a ubiquitous language, or mentions domain modeling or DDD.

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