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概要と使いどころ
Analyze TF motif accessibility variability across samples or single cells using chromVAR. Use when identifying TF motifs whose accessibility correlates with conditions, computing per-sample motif z-scores after matched background correction, comparing to ArchR / Signac equivalents, or distinguishing motif-accessibility signal from per-site footprinting.
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Read, write, and query Apple Health data using HealthKit. Covers HKHealthStore authorization, sample queries, statistics queries, statistics collection queries for charts, saving HKQuantitySample data, background delivery, workout sessions with HKWorkoutSession and HKLiveWorkoutBuilder, HKUnit, and HKQuantityTypeIdentifier values. Use when integrating with Apple Health, displaying health metrics, recording workouts, or enabling background health data delivery.
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Transmit and capture RF waveforms using Wireless Testbench with NI USRP radios (X410, X310, N310, N320, N321, N300, X300, E320). Use when generating test signals, transmitting over the air, capturing IQ data, performing loopback tests, configuring multi-antenna setups, or troubleshooting dropped samples and gain settings. Covers basebandTransceiver, basebandTransmitter, basebandReceiver, continuous and once transmit modes, foreground and background capture, and UseRadioBuffer options. Also use when the user mentions transmit waveform, capture signal, IQ data, loopback, RF gain, sample rate, or antenna configuration.
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Generate database seed scripts with realistic sample data. Reads Drizzle schemas or SQL migrations, respects foreign key ordering, produces idempotent TypeScript or SQL seed files. Handles D1 batch limits, unique constraints, and domain-appropriate data. Use when populating dev/demo/test databases. Triggers: 'seed database', 'seed data', 'sample data', 'populate database', 'db seed', 'test data', 'demo data', 'generate fixtures'.
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Clinical study operations — protocol structure, endpoint selection, eligibility design, sample-size and power planning, site feasibility, and documentation readiness. Use when planning, auditing, or costing a study.
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This package implements a suite of methods to preprocess data from PTR-TOF-MS instruments (HDF5 format) and generates the 'sample by features' table of peak intensities in addition to the sample and feature metadata (as a single ExpressionSet object for subsequent statistical analysis). This package also permit usefull tools for cohorts management as analyzing data progressively, visualization tools and quality control. The steps include calibration, expiration detection, peak detection and qua
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We propose an Asymmetric Within-Sample Transformation (AWST) to regularize RNA-seq read counts and reduce the effect of noise on the classification of samples. AWST comprises two main steps: standardization and smoothing. These steps transform gene expression data to reduce the noise of the lowly expressed features, which suffer from background effects and low signal-to-noise ratio, and the influence of the highly expressed features, which may be the result of amplification bias and other experi
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Design, plan, and analyze A/B tests with statistical rigor. Use when the user asks about A/B testing, split testing, experiment design, statistical significance, sample size calculation, test duration, multivariate testing, or conversion experiments. Trigger phrases include "A/B test", "split test", "experiment", "statistical significance", "sample size", "test duration", "which version wins", "conversion experiment", "hypothesis test", "variant testing".
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结构化数据分层采样工具。读取 JSONL、JSON、CSV、TSV、XLSX、XLS 等结构化数据，按指定字段分层后无放回抽取样本，输出保留原字段结构的采样结果。 当用户提到分层采样、类别平衡采样、按标签抽样、训练集分层划分等需求时使用此skill。 即使用户没有明确说出"stratified_sampler"，只要任务涉及按字段分层并进行代表性抽样，就应该使用此skill。 不负责随机采样、领域均衡采样、批量切分、时间窗口抽样或格式转换。
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JSONL 随机采样工具。读取 JSONL 数据集，按抽样数量或抽样比例无放回抽取样本，输出保留原字段结构的采样结果。 当用户提到随机采样、按数量抽样、按比例抽样、JSONL 抽样筛查等需求时使用此skill。 即使用户没有明确说出"random_sampler"，只要任务涉及对 JSONL 记录做无放回随机抽取，就应该使用此skill。 不负责分层采样、领域均衡采样、表格采样或其他格式转换。
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Inspects videos, extracts frames, and concatenates video clips stored in Volcengine TOS: read video metadata, capture single snapshots, batch-capture multiple frames by explicit timestamps or interval, concatenate multiple video clips, and save results locally or back to TOS. Use this skill when the user needs to get video duration or codec info, capture a poster image or thumbnail, extract frames at specific timestamps, sample frames at regular intervals, merge or join multiple video clips into one — even if they don't explicitly mention 'video processing' or 'frame extraction'.
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Use when the user wants to analyze dataset bias, create stratified samples, evaluate fairness, or plan dataset collection. Triggers on phrases like "dataset bias", "stratified sample", "class imbalance", "data distribution", "fairness analysis", or "ethical review".
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Query ARCHS4 REST API for uniformly processed RNA-seq expression, tissue patterns, co-expression across 1M+ human/mouse samples. Retrieve z-scores, co-expressed genes, samples by metadata, HDF5 matrices. For variant population genetics use gnomad-database; for pathway enrichment use gget-genomic-databases (Enrichr).
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Counts RNA-seq reads overlapping GTF gene features. Takes sorted STAR BAMs plus GTF; outputs a per-gene tab-delimited matrix across samples. Handles strandedness (0/1/2), paired-end, multi-sample batch counting in one command, and outputs assignment statistics. Use Salmon for alignment-free quantification; use featureCounts when STAR BAMs already exist.
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Use when data needs statistical analysis. Runs reproducible Python/R code for Table 1, diagnostic accuracy, agreement, regression, survival, propensity score, survey-weighted and repeated-measures models, with publication tables. Sample size is /calc-sample-size; pooling studies is /meta-analysis.
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Build consistent characters, environments and props in Guaardvark's Cast Library and train LoRAs for them locally (reference photos → vision bible → sample plan → approved samples → training). Use when the user wants the same face or object across images, videos, a music video, or a Film Crew production, or asks to "train a LoRA".
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Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
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Segments the genome into chromatin states from combinatorial histone modification and chromatin factor ChIP-seq data. Uses ChromHMM (multivariate HMM on binarized signal, v1.27), Segway (Dynamic Bayesian Network on continuous signal), EpiSegMix (flexible-distribution HMM with duration modeling, 2024), EpiLogos (multi-biosample visualization), IDEAS (cell-type-aware joint), and full-stack ChromHMM (Vu Ernst 2022) for cross-cell-type segmentations. Handles state-count selection (15 vs 18 vs 25 states), binarization choice, OverlapEnrichment / NeighborhoodEnrichment downstream analysis, and cross-biosample integration. Use when learning chromatin states from a histone mark panel, characterizing learned states by genomic feature enrichment, or comparing chromatin landscapes across cell types.
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Designs adaptive clinical trials including group-sequential (O'Brien-Fleming, Pocock, Lan-DeMets spending), sample-size re-estimation (blinded Friede-Kieser, unblinded Cui-Hung-Wang, Mehta-Pocock promising zone), seamless Phase 2/3 with treatment-arm selection, population enrichment, and response-adaptive randomisation. Covers FDA 2019 Final Adaptive Designs Guidance, FDA 2022 Master Protocols, and ICH E20 Step 2b/3 draft (June 2025, NOT final). Use when planning interim analyses, sample-size re-estimation, or master/platform-trial designs.
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Plans a controlled experiment (A/B test) so its result can be trusted: writes the hypothesis, picks one primary metric and the guardrails, computes sample size and run time, specifies how visitors are assigned and when exposure is logged, and reads out the result with a confidence interval. Use when someone says "set up an A/B test", "split test this page", "how many visitors do I need", "how long should the experiment run", "is this result significant", "can I stop the test early", or wants to test a headline, price, layout or onboarding change against the current version.
日本語の概要は準備中です。原文の説明を表示しています。
Suede Labs skill that finds and organizes the rights gaps in a creator project before packaging: ownership, contributors, splits, samples, licenses, provenance, metadata, licensing readiness, and royalty-routing readiness, each marked confirmed or unknown against an evidence trail. Use when a song, release, or creative project needs a rights check before registry, licensing, sync, or payout discussion; when splits, sample clearance, or chain of title are unclear; or when someone asks whether they have the rights to release, license, or get paid for a work. Organizes evidence only: clears no rights, confirms no ownership, moves no money, writes to no registry. NOT FOR: building the transfer package itself (use suede-rights-passport); linting a release folder's files and metadata (use suede-release-linter); a sync one-sheet or pitch (use suede-sync-packaging).
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Your team has high autonomy — and standups are vague, weekly meetings drift into status reports, and 1:1s produce nothing but "I'm fine." This playbook fixes all three layers at once. What's inside: • Daily Standup system — 3-field format, good sample, 4 COO principles to keep it honest • Weekly Meeting — strict 25-min agenda, Scrum Master rotation, 0–10 pulse check • 1:1 Framework — 9-dimension quantified pulse, 5-group deep question bank, bilateral feedback structure • Diagnostic layer — "stuck-at" detection: info / authority / collaboration / capability / direction • FAQ for 4 common failure modes (dead standups, status-report meetings, "I'm fine" 1:1s, scaling beyond 10 people) 🇨🇳 你的团队自由度很高——但 standup 越来越糊，例会变成汇报，1:1 问不出真话。这套三层 Motivation 操作手册解决的正是这件事：standup 是信息层，例会是对齐层，1:1 是个人层。三件事做好了，motivation 不是管出来的，是长出来的。 🇯🇵 チームの自律性は高いのに、スタンドアップは曖昧で、週次ミーティングは進捗報告になり、1on1では「大丈夫です」しか返ってこない——このプレイブックは、その3層すべてを同時に解決します。 🇰🇷 팀의 자율성은 높은데 스탠드업은 두루뭉술하고, 주간 회의는 진척 보고가 되어버리고, 1:1에서는 진심을 들을 수 없다면 — 이 플레이북이 세 레이어 모두를 동시에 해결합니다. Triggers: "团队 motivation" | "standup 没人写" | "例会变成汇报" | "1:1 问不出真话" | "高自由度团队管理" | "COO 如何管人" | "team motivation" | "standup best practices" | "1on1 framework" | "weekly meeting template" | "チームモチベーション" | "팀 동기부여" | "AI startup team ops" | "remote team alignment" | "engagement下降"
A/B test design — produce an experiment spec with hypothesis, primary metric, MDE, sample size, run time, and decision rule. Also determines when NOT to A/B test and what to do instead. Use when asked to "design an A/B test", "should we test this", "experiment design", "how do we know if this works", "what's the sample size", or "set up an experiment".
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A/B testing, randomization, sample size calculation, confounding control, and causal inference for data science. Covers the full experimental lifecycle from hypothesis formulation through power analysis, randomization strategies, blocking, factorial designs, sequential testing, and the potential outcomes framework for causal claims. Use when designing experiments, planning A/B tests, calculating sample sizes, or reasoning about causation from data.
日本語の概要は準備中です。原文の説明を表示しています。