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概要と使いどころ
Deep reasoning mode for complex problems requiring maximum cognitive depth. Use when facing difficult architectural decisions, complex debugging, multi-step problem solving, or situations requiring careful analysis before implementation.
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Use when implementing or debugging ANY network request, API call, or data fetching. Covers fetch API, React Query, SWR, error handling, caching, offline support, and Expo Router data loaders (`useLoaderData`).
日本語の概要は準備中です。原文の説明を表示しています。
iOS and Swift/SwiftUI development guidance, including UI patterns, Liquid Glass styling, performance audits, view refactors, Swift concurrency, and iOS debugging. Use when building or reviewing iOS apps, SwiftUI views, or troubleshooting iOS issues.
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Expert Bash help for writing, debugging, and optimizing safe, portable shell one-liners and scripts on macOS/Linux. Use when users ask for Bash or POSIX sh commands, script reviews, ShellCheck fixes, quoting/pipeline issues, process/file automation, or converting requirements into shell scripts.
日本語の概要は準備中です。原文の説明を表示しています。
BROWSER VFX ACCEPTANCE SKILL — Use built-in browser/headless browser to automatically verify Cocos VFX block effects and composed VFX recipes in BattleScene preview (`http://localhost:7456`, `previewMode=true`, `previewTarget=5`). USE FOR: VFX health audit, per-block smoke validation, combo recipe regression checks before merging `vfx-block-registry.ts` / `vfx-effects.json`. DO NOT USE FOR: Cocos Editor window screenshot capture, compile-error debugging, or pure log-only diagnosis without browser preview.
日本語の概要は準備中です。原文の説明を表示しています。
COMPLETE BUG INVESTIGATION WORKFLOW — Combines screenshot + log reading into a full triage pipeline. USE FOR: any bug report that has both visual symptoms AND runtime errors, especially CompositePanel / ChildPanel mount failures, screen spec wiring breaks, or battle scene UI crashes. This is the master debugging workflow that orchestrates cocos-screenshot and cocos-log-reader together.
日本語の概要は準備中です。原文の説明を表示しています。
Reproduce failures, trace authoritative flow, prove the broken assumption, and add targeted regression coverage.
日本語の概要は準備中です。原文の説明を表示しています。
Modify NPC behavior, HTN tasks, navigation, steering, prototypes, and AI debugging.
日本語の概要は準備中です。原文の説明を表示しています。
Capture actionable learnings that emerge during conversation — when the agent or user discovers that a skill, a set of skills, or a process needs to be updated based on what's happening in the current chat. Sub-skill of the learn-from orchestrator. Load when the user says "we should update the skill for this", "this should be a skill rule", "add this as a gotcha", "the skill should know about this", "update the process for this", "remember this for next time", "this is important for the skill". Also triggers when the agent notices a skill's guidance was wrong or incomplete, a process step failed or was unnecessary, a new pattern emerged, a guardrail was missing, a workaround became a pattern, or a debugging session reveals a gap.
日本語の概要は準備中です。原文の説明を表示しています。
Append structured execution traces across operational, cognitive, and contextual surfaces with minimal overhead. Load when inspecting agent runs, logging tool calls and observations, enabling post-run debugging, or pairing with structured-planning step IDs. Also triggers on "trace this run", "log execution", "agent observability", "run log", or when fault-localize needs evidence. Default-on during multi-step plans. Traces live at .agent-loom/traces/ — git-ignored by default.
日本語の概要は準備中です。原文の説明を表示しています。
Capture durable project memory from work, debates, debugging discoveries, learned conventions, deferred options, and session outcomes. Load when the user says remember this, save this learning, record what happened, update project memory, or preserve context for future agents.
日本語の概要は準備中です。原文の説明を表示しています。
Select alternative execution paths when a plan step fails — branch on outcomes instead of blind retry. Load when a structured plan step fails, an unexpected observation arrives, or the user asks what to try next after an error. Also triggers on "try another approach", "route around this failure", "replan on failure", "if X fails try Y", or outcome-based branching during multi-step work. Pairs with structured-planning and debug-and-fix. Does not replace root-cause debugging — adds plan-level path selection.
日本語の概要は準備中です。原文の説明を表示しています。
Test and debug browser UIs using Chrome DevTools MCP — DOM inspection, console errors, network requests, performance traces, and visual verification. Load when building or debugging anything that renders in a browser, verifying a UI fix, profiling Core Web Vitals in a real page, or the user asks for browser testing with DevTools. Requires chrome-devtools MCP configured. Not for backend-only or CLI work. Pairs with frontend-design and performance-optimization.
日本語の概要は準備中です。原文の説明を表示しています。
Toolkit for interacting with and testing local web applications using Playwright. Supports verifying frontend functionality, debugging UI behavior, capturing browser screenshots, and viewing browser logs.
日本語の概要は準備中です。原文の説明を表示しています。
Debug LangChain and LangGraph agents by fetching execution traces from LangSmith Studio. Use when debugging agent behavior, investigating errors, analyzing tool calls, checking memory operations, or examining agent performance. Automatically fetches recent traces and analyzes execution patterns. Requires langsmith-fetch CLI installed.
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Systematically finds and fixes bugs using proven debugging techniques. Traces from symptoms to root cause, implements fixes, and prevents regression.
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Loads, converts, and manipulates Hi-C contact matrices in cooler format (.cool/.mcool/.scool) and Juicer .hic, using cooler (Python + CLI), hic2cool, and hictk. Covers the single-resolution mcool URI (file.mcool::/resolutions/<bp>), the load-bearing divisive-vs-multiplicative weight-naming rule (KR/VC/VC_SQRT auto-divisive vs cooler's multiplicative weight), what survives .hic<->.cool conversion (FRAG matrices and norm vectors do not), raw-vs-balanced coarsening, the .pairs upper-triangle/chromsize-order contract, and chrom-naming/bin-table provenance. Use when loading a cooler, converting .hic to .mcool, selecting a resolution, building a cooler from pairs or a matrix, coarsening/zoomifying, importing Juicer norm vectors, or debugging all-NaN balanced matrices and chr1-vs-1 empty fetches.
日本語の概要は準備中です。原文の説明を表示しています。
Handles BED-format genomic intervals (BED3 through BED12, narrowPeak/broadPeak) and the coordinate-system substrate the whole interval category rests on, with bedtools (CLI) and pybedtools/pyranges/pandas (Python). Covers the 0-based half-open vs 1-based-closed convention boundary and the start-1/end-unchanged conversion, the silent failures (chrom-name mismatch, CRLF, lexicographic-vs-version sort under -sorted), genome/chrom.sizes generation, sorting contracts, BED12 block invariants, validation, makewindows, cross-assembly liftover (liftOver/CrossMap), and BED<->VCF/BAM/FASTA conversion. Use when reading, creating, validating, sorting, lifting between genome builds, or converting interval files, preparing inputs for bedtools/tabix/bigBed, or debugging an off-by-one or empty-overlap result.
日本語の概要は準備中です。原文の説明を表示しています。
Stores and operates on sparse expression matrices for single-cell and large bulk RNA-seq, covering dgCMatrix/dgRMatrix/dgTMatrix when-each-is-fast, the dgCMatrix (CSC, R) <-> CSR (Python) implicit transpose, AnnData (cells-rows) <-> SingleCellExperiment (cells-cols) orientation flip, HDF5/h5ad vs Zarr cloud-native shift, HDF5SummarizedExperiment + DelayedArray for out-of-memory bulk, scanpy backed mode for large h5ad, the ~10-15% density crossover where dense beats sparse, 10X format proliferation (MTX vs CellRanger H5 vs h5ad), the dense-conversion memory blow-up, and Dask + Zarr for consortium-scale matrices. Use when choosing sparse format, working with single-cell-sized matrices, importing/exporting 10X, debugging R/Python interop transposes, processing matrices too large for RAM, or building cloud-native pipelines.
日本語の概要は準備中です。原文の説明を表示しています。
Imports gene expression count matrices from featureCounts, HTSeq, STAR ReadsPerGene, Salmon/kallisto via tximport or tximeta, RSEM, 10X Genomics MTX/H5, AnnData H5AD, and RDS. Handles silent-miscounting traps (featureCounts -p v2.0.2 API break, STAR strandedness column choice, salmon NumReads-sum without tximport, RSEM non-integer expected_count, GENCODE _PAR_Y suffix, zero-length-transcript TPM divide-by-zero), and encodes the tximport countsFromAbundance decision tree with the "lengthScaledTPM is not TPM" warning. Use when assembling a gene-by-sample count matrix from aligner or quantifier output, importing salmon/kallisto for DESeq2 vs limma-voom, choosing strandedness column for STAR, debugging zero-count panics, or building tx2gene mapping.
日本語の概要は準備中です。原文の説明を表示しています。
Normalizes and transforms RNA-seq count matrices for DE, visualization, clustering, and ML. Covers between-sample (TMM, TMMwsp, RLE/median-of-ratios, upper quartile), within-sample (TPM, FPKM/RPKM), variance-stabilizing (VST, rlog, log-CPM), GC-content correction (cqn, EDASeq), and single-cell (scran deconvolution, scanpy normalize_total). Encodes the composition-bias rationale, the "most genes not DE" assumption and its catastrophic failure modes (MYC amplification, apoptosis, viral host shutoff, prokaryotic stress), the "lengthScaledTPM is not TPM" naming trap, the "TPM is not for DE" rule, the blind=TRUE vs FALSE decision, ERCC spike-in normalization (SBN), and the single-cell zero-inflation breakdown of TMM/RLE. Use when choosing or applying normalization, debugging shifted-MA-plot diagnostics, handling zero-heavy single-cell data, or correcting GC bias.
日本語の概要は準備中です。原文の説明を表示しています。
Analyzes pooled CRISPR screens with MAGeCK (Li et al 2014), covering count generation (mageck count), the RRA two-condition workflow (mageck test using alpha-RRA over per-sgRNA negative-binomial p-values), the MLE multi-condition workflow (mageck mle with explicit design matrix and beta-score output), normalization choice (median vs total vs control-sgRNA vs spike-in), sgRNA efficiency injection, paired-sample testing, time-course design, drug-screen versus dropout-screen design matrices, MAGeCKFlute and MAGeCK-VISPR downstream visualization, and decision logic for when to use MAGeCK vs JACKS / BAGEL2 / drugZ / Chronos. Use when running a fresh CRISPR screen analysis, picking RRA vs MLE for the experimental design, choosing a normalization method from QC signatures, debugging MLE convergence failure or NaN beta scores, comparing MAGeCK output across tools, or building a batch-aware multi-cell-line / multi-condition MLE design matrix.
日本語の概要は準備中です。原文の説明を表示しています。
Quantifies CRISPR editing outcomes with CRISPResso2 (Clement 2019 Nat Biotechnol) across Cas9-nuclease (indels, HDR), CBE and ABE base editors (target conversion + bystander), and prime editor (pegRNA-templated) modes. Covers single-amplicon (CRISPResso), multi-sample batch (CRISPRessoBatch), pooled-amplicon (CRISPRessoPooled), WGS off-target (CRISPRessoWGS), and sample-comparison (CRISPRessoCompare) workflows; quantification-window math that controls what is called edited; substitution-vs-indel diagnostic to distinguish BE from Cas9 contamination; MMEJ deletion pattern interpretation; allele-frequency tables; and failure modes from amplicon misalignment or contamination. Use when quantifying editing from amplicon sequencing, choosing CRISPResso mode by design, distinguishing intended edits from bystanders and indel byproducts, debugging low-alignment runs, or generating publication-grade editing reports.
日本語の概要は準備中です。原文の説明を表示しています。
Reads, writes, and converts molecular file formats (SMILES, InChI, SDF V2000/V3000, MOL2, PDB, MMTF) using RDKit and Open Babel with rigorous handling of aromaticity perception, stereochemistry, implicit/explicit hydrogens, kekulization, and salt/fragment separation. Use when loading chemical libraries, debugging parse failures, or preparing molecules for downstream standardization, descriptor calculation, or docking.
日本語の概要は準備中です。原文の説明を表示しています。