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概要と使いどころ
Extracts and assigns COSMIC v3.4 mutational signatures (84 SBS / 11 DBS / 18 ID / 24 CN / 16 SV) from somatic VCFs using SigProfilerSuite, MutationalPatterns, MuSiCal mvNMF, SigNet, or HRDetect. Use when characterizing DNA-damage etiology (BRCA1/2 HRD, MMR-D, POLE, APOBEC3A, UV, tobacco, aflatoxin, 5-FU/SBS17b, platinum, colibactin SBS88), routing PARP inhibitor decisions, or auditing de novo extraction vs refit choice for cohort size.
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Profiles RNA-binding protein targets without antibody or UV crosslinking using STAMP (APOBEC1-RBP fusion, C-to-U editing), scSTAMP (single-cell), TRIBE/HyperTRIBE (ADAR-RBP, A-to-I editing), DART-seq (APOBEC1-YTH for m6A), or Bullseye/SAILOR edit-site detection pipelines. Use when antibody is unavailable or specificity is doubtful, when single-cell RBP profiling is needed (scSTAMP), or when in vivo RBP profiling without UV is preferred.
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Builds QSAR / QSPR models using chemprop D-MPNN, MolFormer, Uni-Mol, ChemBERTa, random forest baselines, and Gaussian processes with explicit handling of OECD 5 principles, applicability domain (kNN, leverage, conformal prediction, Mahalanobis), scaffold-balanced splits, ensemble uncertainty, calibration (Platt, isotonic), feature importance (SHAP, atomic attribution), and prospective validation. Use when building target-specific predictive models from in-house bioassay data, ADMET endpoints, or selectivity profiles.
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Computes and interprets treatment effect measures (OR, RR, RD, HR, NNT) with calibrated confidence intervals (Wilson, Newcombe, Miettinen-Nurminen, MOVER, profile likelihood, Bender NNT) and reports marginal vs conditional estimands per FDA 2023 covariate adjustment guidance. Use when reporting treatment effects in confirmatory trials, comparing effect sizes across studies, or constructing forest plots.
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Trains and applies base-resolution deep learning models on ChIP-seq / ChIP-nexus / CUT&RUN data. Uses BPNet (Avsec 2021 Nat Genet 53:354; soft motif syntax from ChIP-nexus), chromBPNet (Pampari A et al 2025 Nat Genet; bias-factorized base-resolution profiles), EnFormer (Avsec 2021 Nat Methods 18:1196; 196 kb input, ~100 kb effective receptive field), DeepSEA (Zhou 2015; multi-task CNN), and JASPAR 2026 deep-learning collection (1259 BPNet ChIP models). Performs in silico mutagenesis for variant-effect prediction, DeepLIFT/Grad attribution, and TF-MoDISco motif discovery from attribution scores. Use when predicting variant effects on TF binding, discovering soft motif syntax / cooperativity, integrating ChIP-seq with sequence-only predictions, or applying precomputed JASPAR Deep Learning models to new variants.
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Sequence-based deep learning for ATAC-seq using chromBPNet, BPNet, scBasset, or EnFormer. Use when correcting Tn5 bias with neural networks beyond k-mer models, predicting per-base accessibility profiles, scoring in silico variant effects at GWAS or rare-variant SNPs, discovering motifs via DeepLIFT/TF-MoDISco from a trained model, or generating cell-type-specific accessibility predictions for unobserved cell states.
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Use when a carrier is evaluating ELD / telematics / dashcam platforms and needs an objective comparison of Samsara, Motive (formerly KeepTruckin), and Geotab. Covers ELD compliance, AI dashcams, driver scoring, integrations, pricing structure, and which fleet profile suits which platform.
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Design and create a simulation persona for testing an AI agent. Guides through use case selection, voice and language configuration, behavior prompt crafting, and interruption calibration. Use when user says "create a persona", "design a persona", "set up a test persona", "configure simulation persona", or "build a caller profile".
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Live SEO data via DataForSEO MCP server: SERP analysis, keyword research (volume, difficulty, intent, trends), backlink profiles, on-page analysis, competitor and content analysis, business listings, AI visibility (LLM mention tracking), and domain analytics. Requires DataForSEO extension installed. Use when user says "dataforseo", "live SERP", "keyword volume", "backlink data", "AI visibility check", or "real search data".
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Maps intelligence for local SEO: geo-grid rank tracking, GBP profile auditing via API, review intelligence across Google/Tripadvisor/Trustpilot, cross-platform NAP verification, competitor radius mapping, and LocalBusiness schema generation. Three tiers: free (Overpass + Geoapify), DataForSEO, and DataForSEO + Google. Use when user says "maps", "geo-grid", "rank tracking", "GBP audit", "review velocity", "competitor radius", or "SoLV".
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Используйте, когда нужно открыть клиент 1С для базы из runtime profile, посмотреть экран, нажать клавишу или кнопку, дождаться завершения обработки или остановить клиент.
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When the user requests to create or customize an academic personal website from a GitHub template repository. This skill handles the complete workflow of forking academic template repositories (like academicpages.github.io), extracting structured personal information from memory or provided data, and systematically updating configuration files (_config.yml), navigation menus (_data/navigation.yml), content pages (_pages/about.md), and publication listings (_publications/). It specifically handles academic profiles including personal details, education background, research experience, publications, skills, and contact information. Triggers include requests to 'fork and customize academic homepage', 'build personal academic website', 'create research portfolio', or 'set up GitHub pages with academic template'.
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Используйте, когда нужно проверить readiness runtime profile, adapter config и базовые зависимости проекта.
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Complete guide to using and extending Hermes Agent — CLI usage, setup, configuration, spawning additional agents, gateway platforms, skills, voice, tools, profiles, and a concise contributor reference. Load this skill when helping users configure Hermes, troubleshoot issues, spawn agent instances, or make code contributions.
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Supermemory is a state-of-the-art memory and context infrastructure for AI agents. Use this skill when building applications that need persistent memory, user personalization, long-term context retention, or semantic search across knowledge bases. It provides Memory API for learned user context, User Profiles for static/dynamic facts, and RAG for semantic search. Perfect for chatbots, assistants, and knowledge-intensive applications.
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网页登录态管理。使用 OpenClaw 内置 browser (profile=openclaw) 统一管理各平台登录状态，定期检查可用性。
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LinkedIn automation via browser relay or cookies for messaging, profile viewing, and network actions.
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Research venture capital firms, angel investors, and funding sources for startup fundraising. Use when: "投资人调研", "找VC", "research investors", "VC list", "funding sources", "investor database", "天使投资人", "venture capital", "融资对象", "投资人画像". Generates a structured investor research report with firm profiles, investment thesis, portfolio companies, contact strategies, and warm introduction paths. Part of UniqueClub founder toolkit. Learn more: https://uniqueclub.ai Pairs with pitch-deck-creator for complete fundraising preparation.
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Learn and apply how the operator works — operator preference, working style, communication preference, "remember my preference", "I prefer", "don't do that again", "that's not how I work". Read at session start, updated at session end.
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Trust scoring, agent discovery, profiling, wallet/identity lookup, contact, dispatch, and metadata reads/writes via 8K4 Protocol (ERC-8004). Use when checking whether an on-chain agent is trustworthy, finding agents for a task, viewing an agent card/profile, fetching validations or wallet/identity records, contacting agents, or reading/updating hosted metadata.
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Decomposition playbook + anti-temptation rules for an orchestrator profile routing work through Kanban. The 'don't do the work yourself' rule and the basic lifecycle are auto-injected into every kanban worker's system prompt; this skill is the deeper playbook when you're specifically playing the orchestrator role.
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Configure GSD workflow toggles and model profile
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This skill covers deploying anomaly detection systems for industrial control environments using machine learning models trained on OT network baselines, physics-based process models, and behavioral analysis of industrial protocol communications. It addresses building normal behavior profiles for SCADA polling patterns, detecting deviations in Modbus/DNP3/OPC UA traffic, identifying rogue devices, and correlating network anomalies with physical process data from historians.
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Conducts external reconnaissance using Open Source Intelligence (OSINT) techniques to map an organization's external attack surface without directly interacting with target systems. The tester gathers information from public sources including DNS records, certificate transparency logs, search engines, social media, code repositories, and data breach databases to build a comprehensive target profile. Activates for requests involving OSINT reconnaissance, external footprinting, attack surface mapping, or passive information gathering.
日本語の概要は準備中です。原文の説明を表示しています。