「binding」の検索結果

Guidance for .NET MAUI XAML and C# data bindings — compiled bindings, INotifyPropertyChanged / ObservableObject, value converters, binding modes, multi-binding, relative bindings, fallbacks, and MVVM best practices. USE FOR: setting up compiled bindings with x:DataType, implementing INotifyPropertyChanged or CommunityToolkit ObservableObject, creating IValueConverter / IMultiValueConverter, choosing binding modes, configuring BindingContext, relative bindings, binding fallbacks, StringFormat, code-behind SetBinding with lambdas, and enforcing XC0022/XC0025 warnings. DO NOT USE FOR: CollectionView item templates and layouts (use maui-collectionview), Shell navigation data passing (use maui-shell-navigation), dependency injection (use maui-dependency-injection), or animations triggered by property changes (use .NET MAUI animation APIs).

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Guidance for .NET MAUI XAML and C# data bindings — compiled bindings, INotifyPropertyChanged / ObservableObject, value converters, binding modes, multi-binding, relative bindings, fallbacks, and MVVM best practices. USE FOR: setting up compiled bindings with x:DataType, implementing INotifyPropertyChanged or CommunityToolkit ObservableObject, creating IValueConverter / IMultiValueConverter, choosing binding modes, configuring BindingContext, relative bindings, binding fallbacks, StringFormat, code-behind SetBinding with lambdas, and enforcing XC0022/XC0025 warnings. DO NOT USE FOR: CollectionView item templates and layouts (use maui-collectionview), Shell navigation data passing (use maui-shell-navigation), dependency injection (use maui-dependency-injection), or animations triggered by property changes (use .NET MAUI animation APIs).

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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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Precise knowledge on the binding sites of an RNA-binding protein (RBP) is key to understand (post-) transcriptional regulatory processes. Here we present a workflow that describes how exact binding sites can be defined from iCLIP data. The package provides functions for binding site definition and result visualization. For details please see the vignette.

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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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Builds and audits a concept-ontology for a regelrecht corpus to decide and verify reference types — cross-law source-binding vs intra-law source-binding vs open-norm leaf vs external-fact leaf — and to catch concept conflation across laws. Core principle: a value's reference type is fixed by WHO derives it, and a binding is sound only when producer and consumer denote the SAME concept; the lexical surface (the word in the text) is not the concept. Detects false friends (one term, different concepts — e.g. a register-based vs a factual "naar de omstandigheden"-based residence/ingezetene concept), orphan plain-params (a value a regulation actually derives, modeled as a brute input), negation/complement re-entry (¬X modeled as an independent leaf next to X), and duplication (one concept re-entered as several independent leafs, losing the single-source-of-truth invariant). Produces a law-level glossary and a stelsel-level concept map with sound same-concept binding edges and flagged lexical-match-but-concept-mismatch edges. Use when deciding whether a value should be cross-law/intra-law/leaf, when the same term means different things across laws, or when a binding might silently conflate concepts.

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Guide for using JASPAR transcription factor binding profiles with ENCODE ChIP-seq data. Use when users need to find TF binding motifs in ENCODE peaks, validate ChIP-seq targets with known motifs, or scan regulatory regions for TF binding potential. Trigger on: JASPAR, motif database, binding profile, PWM, position weight matrix, TF motif, motif enrichment, motif scanning, binding site prediction.

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Guidance for SPR and BLI binding characterization experiments. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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Use when the user wants to customize keyboard shortcuts, rebind keys, add chord bindings, or modify ~/.claude/keybindings.json. Examples: "rebind ctrl+s", "add a chord shortcut", "change the submit key", "customize keybindings".

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Submit compact BindingDB REST API requests for ligand-target binding lookups by PDB, UniProt, or similarity search. Use when a user wants concise BindingDB summaries; save raw payloads only on request.

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Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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SPR and BLI assay planning, kinetic interpretation, and troubleshooting guidance. Use when: (1) Planning binding kinetics experiments, (2) Troubleshooting poor/no binding signal, (3) Interpreting kinetic data artifacts, (4) Choosing between SPR vs BLI platforms.

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Use this skill when editing CRM Analytics dashboard JSON directly to implement advanced bindings, custom SAQL/SOQL step queries, layout changes, step parameters, or cross-widget interactions. Trigger keywords: dashboard JSON, SAQL step, binding syntax, mustache binding, dashboard REST API, widget layout, step limit, datasetId, datasetVersionId. NOT for building the dashboard in the builder UI or picking chart types — use admin/analytics-dashboard-design. NOT for writing or tuning the SAQL itself — use admin/saql-query-development.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

日本語の概要は準備中です。原文の説明を表示しています。

Predict peptide-MHC class I binding and natural presentation with MHCflurry, NetMHCpan-4.1, and MixMHCpred to nominate candidate CD8 T-cell epitopes. Covers the binding-affinity (BA) vs eluted-ligand (EL/presentation) distinction, why %Rank beats raw nM for cross-allele work, the MS abundance bias that misranks low-expression neoantigens, allele-coverage inequity, and length bias. Use when scanning a protein or peptide set for class I epitopes, scoring neoantigen candidates, or choosing a binding predictor. For CD4/HLA class II see mhc-class-ii-prediction.

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Predict RBP binding from RNA sequence using deep learning models (RBPNet sequence-to-signal, RNAProt RNN, GraphProt2 GCN with structure, DeepCLIP, DeepRiPe multi-modal CNN) for variant-effect prediction, in silico binding-site discovery, model interpretation, and transfer learning from CLIP and RBNS datasets. Use when computational prediction of RBP binding from sequence is needed, evaluating variant effects on binding without further wet-lab experiments, comparing model performance, or training a custom model on ENCODE eCLIP data.

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Hardens LDAP directory services against credential harvesting, LDAP injection, anonymous binding, and channel-binding bypass by enforcing LDAPS, channel binding, and LDAP signing. Use when securing an LDAP or Active Directory environment against these attack classes or auditing directory service configurations for these vulnerabilities.

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Configures and diagnoses Workload Identity Federation for GKE authentication failures for Pods (403 "iam.serviceAccounts.getAccessToken" / permission denied, "could not find default credentials", or GKE metadata server unreachable) by verifying cluster and node-pool Workload Identity configuration, the Kubernetes ServiceAccount (KSA) to IAM binding (direct principal binding and legacy Google ServiceAccount impersonation), target-resource IAM roles, and gke-metadata-server health. Use when setting up KSA/GSA bindings (`roles/iam.workloadIdentityUser`, `iam.gke.io/gcp-service-account`) or when a Pod cannot authenticate to Google Cloud APIs. Don't use for in-cluster Kubernetes RBAC errors (API-server authorization), general workload crashes (use gke-workload-troubleshooting), or Pod Security Standards and NetworkPolicies (use gke-workload-security).

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NodeGroup operation Skill for the edgewize nodegroup project. Use this whenever the user wants to query, create, update, delete, bind, unbind, or troubleshoot NodeGroup resources, including node binding, namespace binding, workspace binding, and deployment/config inspection for nodegroup.

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Predict structures and binding for one defined complex with Boltz. Use when folding a protein, RNA, DNA, or ligand complex, docking one ligand, predicting an interface, or scoring binding. Not for screening libraries or design.

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Create, modify, debug, or review Windows Forms applications only when the request contains a concrete Windows Forms marker. USE FOR: WinForms, Windows Forms, System.Windows.Forms, WinForms Form or UserControl designer files (*.Designer.cs or *.Designer.vb), Visual Studio WinForms Designer, TableLayoutPanel, BindingSource, DataGridView, Control.InvokeAsync, component-tray ownership, or custom control serialization. DO NOT USE FOR: WPF or WPF XAML, including Window.InputBindings, KeyBinding, commands, or DataContext; .NET MAUI; Avalonia; or any request where none of the listed Windows Forms markers is present.

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Guide for theming .NET MAUI apps — light/dark mode via AppThemeBinding, ResourceDictionary theme switching, DynamicResource bindings, system theme detection, and user theme preferences. Use when: "dark mode", "light mode", "theming", "AppThemeBinding", "theme switching", "ResourceDictionary theme", "dynamic resources", "system theme detection", "color scheme", "app theme", "DynamicResource". Do not use for: localization or language switching (see .NET MAUI localization documentation), accessibility visual adjustments (see .NET MAUI accessibility documentation), app icons or splash screens (see .NET MAUI app icons documentation), or Bootstrap-style class theming (see Plugin.Maui.BootstrapTheme NuGet package).

日本語の概要は準備中です。原文の説明を表示しています。