「diff」の検索結果

Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

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Compares Hi-C contact maps between conditions across the right scale -- differential bin-pair contacts (multiHiCcompare, diffHic), differential A/B compartments (dcHiC), differential TAD boundaries (delta insulation), and differential loops (diffloop, DiffHiChIP) -- with distance-stratified between-sample normalization, replicate-aware NB-GLM FDR, HiCRep SCC reproducibility gating, and CNV correction for cancer/aneuploid samples. Use when comparing Hi-C between treatment and control, finding differential contacts/compartments/boundaries/loops, normalizing two maps of unequal depth, choosing a replicate-aware test, gating replicates with SCC, or correcting copy-number artifacts before a tumor-vs-normal comparison.

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Identifies differential m6A methylation between conditions from MeRIP-seq paired IP/input data using exomePeak2 with `bam_ip` + `bam_input` (control arm) and `bam_treated_ip` + `bam_treated_input` (treatment arm) for integrated GC-bias-aware differential calling (Liu 2022 *NAR Genom Bioinform* 4:lqac046), QNB beta-binomial test (Liu 2017 *BMC Bioinformatics* 18:387), MeTDiff HMM-based differential bundled with MeTPeak, RADAR (Zhang 2019 *Genome Biol* 20:294) with its `filterBins -> diffIP -> reportResult` workflow, and the defensible paired-symmetric case of edgeR / DESeq2 on featureCounts-on-peaks matrices when batch / lot covariates need explicit fixed-effect handling (exomePeak2's top-level API does NOT accept arbitrary covariates). Covers paired vs unpaired vs interaction designs, batch confounding (antibody lot, RNA prep, sequencing run) and the per-lot meta-analysis strategy when exomePeak2 is the primary caller, the stoichiometry-vs-expression-vs-IP-efficiency confound that all MeRIP differential methods inherit, normalisation choice (size factor on IP, on input, on per-sample IP/input ratio), the McIntyre 2020 reproducibility caveat, effect-size filtering as a guardrail against under-powered N=2 designs, and orthogonal-validation routes for absolute stoichiometry (GLORI / SAC-seq / m6Anet `mod_ratio`). Use when comparing m6A levels across two or more conditions, choosing between exomePeak2 / QNB / RADAR / MeTDiff for a given design, handling batch confounding when exomePeak2's API is too rigid, normalising against input properly, distinguishing real hyper- / hypo-methylation from expression-level shifts, applying effect-size thresholds, interpreting volcano plots of differential peaks, or planning a follow-up orthogonal stoichiometry validation.

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Locate BotProfile::Difficulty in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "BotProfile::Difficulty" (symbol BotProfile_Difficulty). This is a VIRTUAL function - resolve the BotProfile::Difficulty vtable via RTTI and identify the slot, then emit the slot. Verify by xrefs from expected call sites. vtable slots commonly differ between platforms - never assume identical indices. Trigger: BotProfile_Difficulty, BotProfile::Difficulty

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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

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AIGC 创作工作流 (AIGC 创作工作流 / AIGC Creative Workflow — 以「生成式 AI 视觉创作（图像 + 视频）的工程化创作流水线」为对象的认知操作系统：从「需求/概念（要做什么画面/镜头/风格）→ 模型与工具选型（Midjourney / Stable Diffusion·SDXL·Flux / ComfyUI / 可灵 Kling / 即梦 Jimeng / Runway / Vidu / Sora）→ Prompt 与参数设计（提示词工程、风格描述、负向、种子、CFG/步数/采样器、参考图）→ 可控生成（ControlNet / LoRA / IPAdapter / inpainting / 图生图 / 局部重绘 / 区域控制）→ 批量出图与筛选 → 精修与合成（放大/超分、修手修脸、PS/AE 后期、抠图合成）→ 图生视频/文生视频（首尾帧、运镜、时长、一致性、对口型）→ 商业交付与迭代复现（参数留存、工作流文件复用、版权与可商用判断）」的完整创作-工程-交付决策链。覆盖 (a) 第一性张力 — **可控性/工程化复现（ControlNet/LoRA/ComfyUI 节点工作流/固定种子与参数/可复现可迭代）⇄ 随机性/抽卡玄学（出图随机、prompt 玄学、抽卡刷图、靠运气）**；**审美/创意/艺术指导主导（人的审美判断、概念设计、构图、镜头语言、艺术总监能力——'模型是地板，审美是天花板'）⇄ 工具/模型/参数主导（堆模型能力、堆参数、堆 LoRA、以为换个大模型就行）**；**开源生态/本地可控（Stable Diffusion / ComfyUI / Flux / civitai / liblib 本地部署可定制可控可商用、显卡门槛）⇄ 闭源商业/易用黑盒（Midjourney / 可灵 / 即梦 / Runway 开箱即用但不可精控、按量付费、黑盒）**；**图像生成（T2I/I2I：Midjourney / SDXL / Flux）⇄ 视频生成（T2V/I2V：可灵 / Runway Gen-3 / Vidu / 即梦 / Sora，2024-2025 前沿从图迁移到视频）**；**生产力/商业量产（替代或增强传统设计/插画/电商/广告/影视分镜流程、降本提效、批量）⇄ 纯艺术创作/作者表达（个人风格、实验性、作品集）**；**效率/批量（一次出几十张筛选、商单走量、自动化 pipeline）⇄ 质量/精控（单张精修、商业可用级细节、修手修脸修穿帮）**。(b) 核心工作流 / pipeline（最标准、最易蒸高质量 + CLI 化）— 单图创作链：概念/参考收集（moodboard/风格定位/竞品）→ 模型工具选型（按可控性/风格/成本/可商用判断 MJ vs SD/Flux vs 国产）→ Prompt 与参数设计（主体/风格/光影/镜头/负向词/CFG/采样器/分辨率/种子）→ 首轮出图与方向筛选 → 可控迭代（ControlNet 控构图/姿态/线稿、LoRA 控风格/角色一致性、图生图重绘、inpainting 局部修）→ 放大超分与精修（高清放大/修手修脸/后期调色合成）→ 交付与参数留存（工作流文件/种子/参数复现）。视频创作链：分镜/脚本→首帧出图（图像链产出关键帧）→图生视频（运镜/时长/首尾帧/动态强度）→多镜头一致性（角色/场景/风格统一）→对口型/配音/配乐→剪辑合成→交付。ComfyUI 工程链：节点工作流搭建（加载器/采样/ControlNet/放大/面部修复节点）→ 参数化与复用→批量队列→工作流分享（civitai/openart workflow json）。(c) 工具栈 — 闭源图像（Midjourney v6/v7、DALL·E 3、Adobe Firefly、Ideogram、Recraft）、开源图像与底座（Stable Diffusion 1.5/SDXL/SD3、Flux.1 dev/schnell（Black Forest Labs）、ComfyUI（节点式）、Automatic1111/Forge WebUI、Fooocus）、可控生成插件（ControlNet、LoRA、IPAdapter、AnimateDiff、inpainting/outpainting、ReActor 换脸、面部修复 CodeFormer/GFPGAN、放大 ESRGAN/SUPIR/Topaz）、模型/资源社区（Hugging Face、Civitai、liblib 哩布、吐司 Tusi、openart）、视频生成（可灵 Kling、即梦 Dreamina/Jimeng、Runway Gen-3/Gen-4、Luma Dream Machine、Pika、Vidu、海螺 Hailuo、Sora、Wan 通义万相、MiniMax）、辅助（Magnific 放大、Krea、Photoshop/After Effects 后期、ChatGPT/Claude 写 prompt、reverse prompt 反推）。(d) 知识正典 — AIGC 创作 canon 横跨论文/工程/社区教程：奠基论文（DDPM、Latent Diffusion/Stable Diffusion（Rombach et al）、DiT、ControlNet（Zhang et al）、LoRA、DreamBooth、Textual Inversion、SDEdit、IP-Adapter、视频扩散 SVD/Sora 技术报告）、官方文档与模型卡（Stability AI、Black Forest Labs Flux、ComfyUI 文档、Midjourney docs、可灵/即梦官方教程、Hugging Face diffusers）、社区教程与工作流（ComfyUI 官方示例、civitai 文章、B站/YouTube 创作者长教程、openart workflow）、prompt 工程资源（Midjourney 风格库、提示词指南）。(e) figures/流派 — 模型/工具创造者（Midjourney David Holz、Stability AI Emad/Robin Rombach、Black Forest Labs（Flux，原 SD 团队）、ComfyUI comfyanonymous、ControlNet 张吕敏 Lvmin Zhang、AUTOMATIC1111、可灵/即梦/快手字节团队）、创作者 KOL 与教育者（Midjourney/SD 头部创作者、ComfyUI 工作流大神、AI 视频创作者、国内 B站/抖音 AIGC 教程作者、独立 AI 艺术家）、行业分析与评测（AI 工具评测、生成式 AI 创作生态观察者）。流派分歧：开源可控派（SD/ComfyUI/Flux 本地精控）vs 闭源易用派（MJ/可灵开箱即用）、工程化派（节点工作流/可复现/参数化）vs 玄学抽卡派（prompt 玄学/堆词/抽卡）、审美主导派（'模型是地板审美是天花板'）vs 工具主导派（堆模型堆参数）、图像派 vs 视频派、艺术创作派 vs 商业生产力派、国产工具派（可灵/即梦/liblib）vs 海外工具派（MJ/Flux/Runway）。(f) 行业话术/黑话 — 出图 / 抽卡 / 刷图 / 炼丹（训练 LoRA）/ 喂图 / 垫图（参考图/图生图）/ 控图 / 锁种子 seed / CFG / 采样器 sampler / 步数 steps / 重绘幅度 denoise / 提示词 prompt / 咒语 / 负向 negative / 权重 / tag / 大模型 checkpoint / 底模 / LoRA / ControlNet / 控线稿/openpose/depth / IPAdapter / inpainting 局部重绘 / outpainting 扩图 / 高清放大 / 超分 / 修手 / 崩手 / AI 味 / 风格 / 角色一致性 / 工作流 workflow / 节点 / 跑图 / 队列 / 文生图 T2I / 图生图 I2I / 文生视频 T2V / 图生视频 I2V / 首帧/尾帧 / 运镜 / 动态强度 / 时长 / 对口型 / 一致性 / 可商用 / 训练集 / 过拟合 / 翻车 / 穿帮。(g) 争议/批判 — 「版权与训练数据」（模型训练用未授权作品、生成图版权归属、可商用风险、洗图/伪原创）、「AI 替代创作者就业」（替代画师/插画师/设计师/摄影、行业冲击与转型）、「AI 味与审美趋同」（生成图同质化、套模板、缺乏原创审美）、「玄学 prompt 神话与割韭菜」（'咒语'神秘化、'7天 AIGC 变现/月入过万'付费课割韭菜、抽卡当能力）、「工具快速迭代与淘汰焦虑」（模型月月换、工作流频繁失效、追新疲劳）、「开源 vs 闭源之争」（可控可商用 vs 易用黑盒）、「质量天花板」（修手修脸穿帮、长视频一致性、可控性仍有限）。(h) 大量隐性创作手艺 + 审美 + 工程 + 沟通软技能（prompt 的描述功底与审美词汇、参数与采样的手感、ControlNet/LoRA 的组合控制经验、节点工作流的搭建与调试、批量筛选的审美眼力、修图合成的后期功底、镜头语言与运镜设计、角色/风格一致性的控制、商业需求的翻译与交付、版权与可商用的判断）是高 tacit、靠大量实操跑图 + 审美积累 + 工程调试经验的核心。水分极高（大量'咒语速成/一键变现/AI 绘画割韭菜'营销

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Analyze the dynamics of diffusion processes using stochastic differential equations, Fokker-Planck equations, first-passage time distributions, and parameter sensitivity analysis. Use when deriving probability density evolution for a continuous-time diffusion process, computing mean first-passage times for bounded diffusion, analyzing how drift and diffusion parameters affect process behavior, or validating closed-form solutions against stochastic simulation.

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Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

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「レビューして」「diff をレビュー」「〇〇観点で見て」「PR に出す前にセルフレビュー」などユーザーがコードレビューを依頼したら、観点・レンズ名を挙げていなくても必ず使用する。作業ブランチの diff を複数観点(design / test / yagni、条件付きで spec 等)で並列レビューし統合報告するオーケストレーションスキル。既定は diff 内で完結する fix 指摘のみで、既存コードへの改善提案(リファクタ候補の洗い出し)は起動引数 --improvement の明示時のみ報告する。コードの修正は行わない。

Compare gene co-expression and regulatory networks between biological conditions to find rewired relationships using DiffCorr, DiffCoEx, DINGO/iDINGO, and CoDiNA. Covers the differential-connectivity-is-not-differential-expression distinction, the pairwise multiple-testing explosion, marginal vs partial (direct) rewiring, and the underpowered-rewiring failure mode. Use when comparing co-expression networks between disease vs control, treatment, or developmental stages, or finding hub genes that rewire without changing mean expression. For single-condition modules see coexpression-networks; for differential expression of means see differential-expression/de-results.

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編集前後の文章やパッチから、変更箇所を比較できる画面とPNG・PDFを作るスキル。共有用URLや添付ファイルで、修正内容を具体的に伝えられます。

• 文章の変更箇所をURLで共有したいとき
• 差分をPNGやPDFで添付したいとき
• 修正確認用の高品質な資料作成

State-of-the-art text-to-image generation with Stable Diffusion models via HuggingFace Diffusers. Use when generating images from text prompts, performing image-to-image translation, inpainting, or building custom diffusion pipelines.

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State-of-the-art text-to-image generation with Stable Diffusion models via HuggingFace Diffusers. Use when generating images from text prompts, performing image-to-image translation, inpainting, or building custom diffusion pipelines.

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Econometrics skill for Difference-in-Differences (DID) analysis. Activates when the user asks about: "difference in differences", "DID", "DiD", "diff-in-diff", "parallel trends", "treatment group", "control group", "pre-treatment", "post-treatment", "policy evaluation", "natural experiment", "staggered DID", "event study regression", "two-way fixed effects DID", "callaway santanna", "sun and abraham", "双重差分", "倍差法", "平行趋势", "处理组", "对照组", "政策评估", "事件研究", "交错DID", "渐进处理"

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Compare cell-type composition and spatial features across conditions in IMC/MIBI cohorts with the patient as the experimental unit, covering pseudoreplication, per-patient aggregation, mixed models, compositional (Dirichlet/scCODA) differential abundance, diffcyt, per-image-to-patient spatial differential testing (SpaceANOVA), batch covariates, and FDR. Use when testing whether a cell type or spatial niche differs between groups, avoiding cell-level pseudoreplication, choosing a differential-abundance method, or correctly powering an IMC cohort comparison.

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Adapts an existing K-12 lesson (math, ELA, science, or social studies) for students at different proficiency levels (below / at / above grade level). Load this skill BEFORE asking the teacher any clarifying question about the lesson, tiers, or student levels. Triggers on explicit asks to differentiate, tier, or scaffold a lesson, and on implicit signals like "my students are at different levels". Produces 1 teacher-facing differentiation plan + 3 student-ready tier documents as editable Word documents in a single output turn, rendered from one material-source JSON via bundled scripts (shared content is written once so tiers cannot drift). Uses the Learning Commons Knowledge Graph when connected; works without it. This skill adapts a lesson the teacher brings or names. Not for creating a new lesson from scratch — a new-lesson request that asks for differentiated or leveled materials is k12-lesson-plan-creation's job, one package. Not for grading, rubrics, assessment feedback, or quizzes.

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DiffDock and DiffDock-L diffusion-based molecular docking. Use for blind protein-small-molecule pose prediction from a PDB file or sequence plus SMILES/SDF/MOL2, batch docking over a CSV of complexes, virtual screening triage, sampling multiple poses per complex, and reading the confidence score correctly. Also trigger on DiffDock, DiffDock-L, inference.py, confidence_model, samples_per_complex, ESM embedding preparation for docking, or blind docking without a defined box. Not for binding affinity prediction — the confidence score ranks pose plausibility, not potency.

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Econometrics skill for Difference-in-Differences (DID) analysis. Activates when the user asks about: "difference in differences", "DID", "DiD", "diff-in-diff", "parallel trends", "treatment group", "control group", "pre-treatment", "post-treatment", "policy evaluation", "natural experiment", "staggered DID", "event study regression", "two-way fixed effects DID", "callaway santanna", "sun and abraham", "双重差分", "倍差法", "平行趋势", "处理组", "对照组", "政策评估", "事件研究", "交错DID", "渐进处理"

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State-of-the-art text-to-image generation with Stable Diffusion models via HuggingFace Diffusers. Use when generating images from text prompts, performing image-to-image translation, inpainting, or building custom diffusion pipelines.

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リファクタリングを「更新されたチームの理解と、コードが表現する過去の理解の差分同期」と捉え、今回得た新知識（要求・ドメイン知識・制約）が naming と responsibility へ反映されているか、boundary が現在の understanding を表現しているか、diff の削除行やコメントに現れる過去の design history と constraint を失っていないかを diff-time で確認する。Knowledge Delta の signal は diff（追加/削除された hunk・コメント・ADR 参照）を一次情報とし、PR 本文が供給されるときは補助に用い、不確実なら question に留める。ドメイン用語の一貫性は ubiquitous-language-naming、集約/コンテキスト境界の設計判断は bounded-context-language、投機的抽象化・caller special-case は altitude-generalization、スコープ逸脱/前提破壊は fix-scope-integrity、振る舞い変更と構造変更の分離は behavior-structure-separation、完了主張の反証は refactor-claim-audit へ委譲する

Compare cell-type composition and spatial features across conditions in IMC/MIBI cohorts with the patient as the experimental unit, covering pseudoreplication, per-patient aggregation, mixed models, compositional (Dirichlet/scCODA) differential abundance, diffcyt, per-image-to-patient spatial differential testing (SpaceANOVA), batch covariates, and FDR. Use when testing whether a cell type or spatial niche differs between groups, avoiding cell-level pseudoreplication, choosing a differential-abundance method, or correctly powering an IMC cohort comparison.

日本語の概要は準備中です。原文の説明を表示しています。

State-of-the-art text-to-image generation with Stable Diffusion models via HuggingFace Diffusers. Use when generating images from text prompts, performing image-to-image translation, inpainting, or building custom diffusion pipelines.

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N-day 补丁差分到利用。从厂商发布的补丁里反推漏洞点、写 PoC、做成可用的攻击模块。 适用场景：已知 CVE 编号但只有补丁没有 PoC、SRC/红队需要打击未及时更新的资产、N-day 武器化、Patch Tuesday 跟进。 核心方法：拿 before/after 二进制 → 对齐符号 → 二进制 diff → 看新增的安全检查反推 bug class → 写 PoC 触发漏洞。 触发关键词：N-day、Nday、补丁差分、patch diff、patch tuesday、1day、binary diff 漏洞、bindiff 利用、ghidriff、Diaphora、补丁分析、CVE 复现、漏洞还原、补丁反推、N-day 武器化。

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Predict small-molecule binding poses with DiffDock-L (Corso et al. 2023/2024, github.com/gcorso/DiffDock) — blind diffusion docking that places a ligand into a protein pocket without a predefined search box and ranks the samples with a learned confidence model. Reach for this skill to dock a SMILES or SDF against a PDB, to generate ranked 3D poses for a small fragment library, or to get a starting pose for downstream rescoring. DiffDock predicts geometry, not affinity.

日本語の概要は準備中です。原文の説明を表示しています。