「mutations」の検索結果

Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.

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Detects somatic mutations in circulating tumor DNA using variant callers optimized for low allele fractions with UMI-based error suppression. Reliably detects mutations at VAF above 0.5 percent using consensus-based approaches. Use when identifying tumor mutations from plasma DNA or tracking specific variants.

日本語の概要は準備中です。原文の説明を表示しています。

TanStack Query (React Query) v5 best practices for data fetching, caching, mutations, and server state management. Use when building data-driven React applications, setting up query configurations, implementing mutations/optimistic updates, configuring caching strategies, integrating with SSR, or fixing v4→v5 migration errors.

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TanStack Query (React Query) v5 best practices for data fetching, caching, mutations, and server state management. Use when building data-driven React applications, setting up query configurations, implementing mutations/optimistic updates, configuring caching strategies, integrating with SSR, or fixing v4→v5 migration errors.

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Implement React Server Actions in Next.js 14+ for secure, progressively enhanced form handling and server mutations without API routes. Use when handling form submissions, performing server-side mutations, implementing progressive enhancement, creating actions that work without JavaScript, validating data on the server, revalidating cached data after mutations, handling file uploads server-side, implementing optimistic UI updates, or building forms that gracefully degrade without client-side JavaScript.

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Hunt fintech-specific GraphQL vulnerabilities: money-movement mutations (transfers, redemptions, withdrawals, card top-ups), ledger/balance/portfolio query IDOR, decimal-precision and rounding abuse, idempotency-key bypass enabling double-spend, KYC/PII field-level authorization gaps, and admin-override mutations reachable via mass assignment. Distinct from hunt-graphql, which owns generic GraphQL discovery and IDOR/mutation methodology — this skill owns the delta introduced when a GraphQL layer sits in front of a ledger, wallet, payments, banking, brokerage, or lending backend, where a resolver bug moves real money instead of just leaking data. Use when hunting a fintech, banking, payments, wallet, neobank, brokerage, or lending target that exposes a GraphQL API, or when a schema/response includes balance, transfer, ledger, redeem, quote, KYC, or account-linking fields.

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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.

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Detects somatic mutations in circulating tumor DNA, treating low-VAF detection as a signal-versus-noise problem set by error suppression and molecules sampled, not by the choice of caller. Distinguishes de novo CALLING (scanning a panel for unknown variants, bounded by per-locus error and multiple testing) from tumor-informed DETECTION (tracking a pre-specified variant set, where panel integration reaches single-ppm). Covers VarDict and Mutect2 for de novo calling, UMI-aware callers, and a pysam-based known-variant VAF tracker, with matched-WBC subtraction as the mandatory defense against clonal hematopoiesis (the dominant false positive). Use when calling or tracking tumor mutations from plasma cfDNA, setting a VAF threshold, or deciding whether a low-VAF call is tumor versus CHIP.

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Expert-level genetics covering Mendelian inheritance, molecular genetics, mutations, linkage analysis, population genetics, epigenetics, and GWAS. Covers classical and modern approaches from Mendel to CRISPR.

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Use this skill when implementing form submissions, data mutations, or any 'use server' function in Next.js 16. Trigger words: フォーム送信, mutation, 更新処理, 保存, Server Action, use server, useActionState, revalidatePath, データ更新.

Performs GraphQL introspection attacks to Şunu çıkar: full API schema including types, queries, mutations, subscriptions, and field definitions from GraphQL endpoints. The tester uses introspection queries to map the attack surface, identifies sensitive fields and mutations, tests for query depth and complexity limits, and exploits GraphQL-specific vulnerabilities including batching attacks, alias-based brute force, and nested query DoS. Activates for requests involving GraphQL security testi...

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Build real-time, reactive backend applications with Convex using TypeScript queries, mutations, and actions with automatic reactivity and optimistic updates. Use when building real-time collaborative applications, implementing reactive data synchronization, writing serverless backend functions, creating queries that auto-update, implementing mutations with transactional guarantees, handling file uploads with Convex storage, implementing authentication with Convex Auth, designing reactive database schemas, or building applications requiring instant data synchronization.

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Query AWS resources using natural language. Covers EC2, S3, RDS, Lambda, ECS, EKS, Secrets Manager, IAM, VPC, networking, messaging, and more. Strictly read-only — no writes, deletes, or mutations.

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Generate domain permutations with dnstwist and check DNS resolution to detect typosquatting, homograph phishing, and brand impersonation domains registered against your organization. Use when asked to monitor for lookalike domains, investigate a phishing domain, or assess brand-impersonation risk.

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Analyze and design control flows and data structures. Produces compact ASCII tree diagrams showing triggers, call chains, payload shapes, state mutations, and re-render effects. Use when user asks to diagram, trace, visualize, or design a flow or data structure.

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Detect and use the official Obsidian command-line interface for read-only vault access; use for wiki-cli, Obsidian CLI, Obsidian read, Obsidian search, vault transport, which transport, transport detection, backlinks, tags, or Obsidian command line. Mutations always go through the claude-obsidian transaction core.

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Design and build reactive, type-safe, production-grade backends on Convex. Covers schema, queries/mutations/actions, indexes, auth, file storage, scheduling, real-time multiplayer, mobile backends, and LLM/agent workflows on Convex's one-platform stack.

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Convex backend specialist. Use this agent for any code inside a `convex/` directory — function definitions, schemas, indexes, queries, mutations, actions, HTTP endpoints, cron jobs, file storage, auth wiring, and component installation. Knows the object-form function syntax, validator patterns, resource limits, and component ecosystem that generic Claude routinely gets wrong.

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Configures mewt or muton campaigns, analyzes surviving mutants, and investigates bugs exposed by testing gaps. Use when setting up mutation testing, reviewing campaign results, identifying equivalent mutants, or finding bugs from surviving mutations.

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Submit compact cBioPortal API requests for studies, molecular profiles, mutations, clinical data, and samples. Use when a user wants concise cBioPortal summaries

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Governs how the OpenBot browser app reads and writes server data — every request goes through `client` in app/src/lib/client.ts, every read is a queryOptions factory in app/src/lib/<entity>/queries.ts, every write is a mutationOptions factory in app/src/lib/<entity>/mutations.ts, and components consume them through useQuery/useMutation. Use when adding or changing a screen that loads server data, calling a /api/... endpoint from the browser, adding a query key, writing a create/update/delete flow, deciding where a fetch belongs, or reviewing a diff that contains the word fetch under app/src. Don't use for server-side route handlers under server/ (that is not browser code), for form validation schemas (those live in lib/<entity>/form.ts), for page layout and Item rows, or for the AG-UI stream itself, which the runtime carries rather than the client.

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GraphQL queries, mutations, and code generation patterns. Use when creating GraphQL operations, working with Apollo Client, or generating types.

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Pseudo-mutation analysis ONLY: answer whether tests would catch a bug if production code changed, which meaningful changes would still pass, or which caller-visible mutations existing assertions would miss; verify candidates when requested, then optionally close verified gaps. Includes explicit read-only per-test composition for grading. Activate for behavioral blind spots tied to production behavior. Polyglot. DO NOT USE FOR: suite taxonomy, metadata, or distribution reports (test-tagging); .NET line-vs-branch or Cobertura interpretation, arithmetic, plateaus, project-wide coverage gaps, or coverage-backed test/CRAP priorities (coverage-analysis; use native coverage tooling outside .NET); named-target CRAP (crap-score); new suites (code-testing); assertion/smell audits; or mutation tools.

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Hunting skill for graphql vulnerabilities. Built from 12 public bug bounty reports across IDOR via node() / GID, mutation IDOR including AI/LLM features, cross-tenant IDOR, SSRF via argument, batching-DoS, query-cost-bypass, SQLi via argument, broken-object-level-authz, auth-bypass via unscoped mutations, and PII exposure from missing field-level authz. Use when hunting graphql on any target.

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