Batch Cohort Analysis Skill

Generate one analysis script per exposure/outcome combination from a single validated methodology template; only the variables change between scripts.

Inputs

1. Database path(s): CSV/SAS data files (KNHANES, NHANES, NHIS, or any cleaned cohort)
2. Methodology template: One of:
   • Path to a validated R/Python analysis script (from /replicate-study or /cross-national)
   • A paper type template name: nhis_cohort, cross_national, survey_weighted
   • A source paper to extract methodology from (falls back to /replicate-study Phase 1)
3. Combination spec: A list of exposure/outcome pairs, provided as:
   • Inline list: exposures: [depression, obesity, smoking]; outcomes: [diabetes, hypertension, CVD]
   • CSV file with columns: exposure, outcome, (optional) subgroup_vars
   • "all" keyword: generates all pairwise combinations from the lists

Optional Inputs

• Covariate set: Fixed covariate list for all analyses (default: use template's set)
• Subgroup variables: Variables to stratify by (default: sex, age group)
• Output format: code_only (just scripts) | execute (run + collect results) | full (code + results + summary)
• Cross-national mode: cross_national: true generates paired scripts for both countries per combination (see Cross-National Batch Mode)

Example:

/batch-cohort

DB Korea: /path/to/knhanes/HN18.csv
DB US: /path/to/nhanes/
Template: cross_national
Exposures: [depression, obesity, smoking]
Outcomes: [diabetes, hypertension, metabolic_syndrome]
cross_national: true
Mode: execute

Workflow

Phase 1: Template Validation

1. Read the methodology template (R script or paper type reference).
2. Identify the slot variables — parts that change per combination: EXPOSURE_VAR (raw variable name in the database), EXPOSURE_LABEL (label for tables/figures), EXPOSURE_CODING (derivation of the binary/categorical exposure), and OUTCOME_VAR, OUTCOME_LABEL, OUTCOME_CODING likewise.
3. Confirm the survey design: weighted analysis is mandatory for KNHANES/NHANES and is inherited from the template; NHIS and other claims databases have no sampling weights (standard regression).
4. Verify the template runs successfully on at least one combination before batch generation.
5. Output: template summary with identified slots → user approval.

Phase 2: Variable Specification

For each exposure and outcome in the combination spec:

1. Look up the variable in the database: KNHANES — the name exists in the CSV header; NHANES — which table contains it (codebook.csv if available); NHIS — claims code or variable name. For ICD-10 claims algorithms read ${CLAUDE_SKILL_DIR}/../analyze-stats/references/analysis_guides/nhis_icd10_mapping.md; for survey variable coding, survey_weighted.md in the same folder. If a mapping is uncertain, write [VERIFY: variable_name] and ask the user to confirm it against the data dictionary; never guess a variable name, column name or coding.
2. Define coding: binary as a threshold or category mapping (e.g., HE_glu >= 126 → diabetes = 1); categorical as level definitions (e.g., smoking: current/former/never). Outcome definitions MUST include physician diagnosis, because lab-only definitions systematically overestimate exposure→outcome associations: Diabetes = FPG≥126 OR HbA1c≥6.5 OR physician-diagnosed (KNHANES: DE1_dg=1, NHANES: DIQ010="Yes"); Hypertension = SBP≥140 OR DBP≥90 OR physician-diagnosed (KNHANES: DI1_dg=1, NHANES: BPQ020="Yes").
3. Set covariates: the full 8-covariate set (age, sex, education, income, smoking, alcohol, obesity, CVD) is the default unless explicitly justified — minimal models (age+sex+BMI only) leave residual confounding, which can bias effects in either direction. Remove self-adjustment: if the exposure is (or derives from) a covariate, drop that covariate (exposure = BMI → drop obesity; exposure = education/income → drop the same variable); if outcome = MetS, consider dropping obesity. Document every removal in the matrix Notes.
4. Output: combination matrix (combination_matrix.csv) with all variable specifications.

| # | Exposure | Exposure Coding | Outcome | Outcome Coding | Covariates (adjusted) | Notes |
|---|----------|-----------------|---------|----------------|----------------------|-------|
| 1 | Depression (PHQ≥10) | BP_PHQ sum ≥10 | Diabetes | HE_glu≥126|HbA1c≥6.5|DE1_dg=1 | age,sex,edu,income,smoking,alcohol,obesity,CVD | — |
| 2 | Obesity (BMI≥25) | HE_obe ≥4 | Diabetes | same | age,sex,edu,income,smoking,alcohol,depression,CVD | obesity removed from covariates |

Phase 3: Batch Code Generation

Never modify the core methodology across combinations — only swap exposure/outcome/covariates. For each combination in the matrix:

1. Clone the template script.
2. Replace slot variables with the combination-specific values.
3. Apply the combination's adjusted covariate set from the matrix.
4. Set output paths: each combination gets its own results subdirectory.
5. Generate a master runner script (run_all.R or run_all.sh) that executes all N scripts sequentially (or in parallel via future/parallel), captures errors per script without stopping the batch, and logs execution time per analysis.
6. Generated-code quality gate: one reproducibility slip (a missing seed, an absolute path, a hand-typed data literal) replicates across the whole batch, so lint the generated scripts with the /analyze-stats code-quality gate (python3 ${CLAUDE_SKILL_DIR}/../analyze-stats/scripts/check_generated_code.py --code-dir {batch_dir} --strict) and clear every Major (MISSING_SEED, HARDCODED_DATA_LITERAL, HARDCODED_ABS_PATH, INPLACE_SOURCE_OVERWRITE) before batch execution.

Phase 4: Batch Execution (if execute or full mode)

1. Event count check: before running, verify ≥10 outcome events per model parameter (count the exposure and every dummy/spline term; use min(events, non-events)), in the full sample and in each subgroup that is modelled. Flag underpowered combinations.
2. Run the master script.
3. Collect results from each combination's output directory.
4. Log which combinations failed and why (common: convergence issues, too few events, empty subgroups) in failed_runs.csv, and suggest fixes.

Phase 5: Summary Matrix

Aggregate all results into a single summary. Every number comes from a combination's executed results files; never fill a cell by hand.

Main Results Matrix (summary_matrix.csv):

Exposure	Outcome	N	Events	Model 1 OR (95% CI)	Model 2 OR (95% CI)	Model 3 OR (95% CI)	p-value	Significant

Subgroup Summary (subgroup_matrix.csv): Same format, stratified by subgroup variables.

Heatmap (optional): Visual matrix of effect sizes × significance, exposure on Y-axis, outcome on X-axis.

• Multiple comparisons: whenever more than one combination is tested, include a Bonferroni- (or Holm-) corrected significance column in the summary matrix, with m = the number of tests in the reported family (combinations × models × subgroups), state m, and add a note on exploratory vs confirmatory framing.
• No p-hacking framing: the summary matrix is for hypothesis generation, not confirmation. State this explicitly in README and any manuscript output. Any citation there needs a /search-lit-confirmed DOI/PMID; otherwise mark it [UNVERIFIED - NEEDS MANUAL CHECK].

Output Files

{working_dir}/batch_{timestamp}/
├── README.md                    — Batch run summary (N combinations, template used, date)
├── combination_matrix.csv       — All exposure/outcome specs with coding
├── template/
│   └── base_template.R          — The validated template (frozen copy)
├── scripts/
│   ├── 01_depression_diabetes.R
│   ├── 02_obesity_diabetes.R
│   ├── ...
│   └── run_all.R                — Master execution script
├── results/
│   ├── 01_depression_diabetes/
│   │   ├── table1.csv
│   │   ├── main_results.csv
│   │   └── subgroup_results.csv
│   └── ...
├── summary/
│   ├── summary_matrix.csv       — Main results across all combinations
│   ├── subgroup_matrix.csv      — Subgroup results across all combinations
│   ├── failed_runs.csv          — Combinations that failed + error messages
│   └── heatmap.png              — Optional effect size × significance visual
└── logs/
    └── batch_execution.log      — Timing + error log

Reproducibility: freeze the template version (template/) and include a SHA256 hash of the data file in README.

Cross-National Batch Mode

When cross_national: true:

• Generate paired scripts for each combination (Korea + US), using /cross-national's dual-survey-design approach
• Summary matrix includes both countries side-by-side, with a ratio-of-ORs column (95% CI; P) computed as in /cross-national Phase 4, not a direction-agreement tick