「aria」の検索結果

Predicts whether a DNA variant alters mRNA splicing using sequence-based deep-learning tools — SpliceAI (10kb context dilated CNN, clinical default), Pangolin (multi-tissue), MMSplice (modular per-region CNN with calibrated ΔPSI), SpliceTransformer/TrASPr (tissue-aware transformers), SpliceVault (empirical 300K-RNA lookup of likely mis-splicing outcomes), CADD-Splice (composite score). Applies the ClinGen SVI 2023 framework for ACMG/AMP variant interpretation (PVS1, PP3, BP4 evidence codes), HGVS splicing nomenclature (c.123+1G>A, c.123-3T>G, r.spl?), extended-window scoring for deep-intronic pseudoexons, tissue-specific predictions, branchpoint variant detection (BPHunter, LaBranchoR), and splice-switching ASO design. Use when interpreting splice impact of clinical variants, prioritizing VUS, identifying deep-intronic pathogenic variants, or designing ASOs.

日本語の概要は準備中です。原文の説明を表示しています。

Locate CCSCustomHudLayout_SetDialogVariableStringForPlayer in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CCSCustomHudLayout_SetDialogVariableStringForPlayer" (symbol CCSCustomHudLayout_SetDialogVariableStringForPlayer). The gamedata consumer stores a BYTE SIGNATURE for this entry - ALWAYS emit the func schema (func_sig), never vfunc fields. The function may be virtual; locating it via the owning class vtable (RTTI) is a fine strategy, but once found, read its head bytes and emit func_sig. Locate via cross-references, distinctive constants/strings, callers of related symbols, or vtable slots; verify by decompilation before committing. Trigger: CCSCustomHudLayout_SetDialogVariableStringForPlayer, CCSCustomHudLayout_SetDialogVariableStringForPlayer

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Locate CCSCustomHudLayout_SetDialogVariableString in CS2 server.dll / libserver.so via IDA Pro MCP and emit a fresh, minimal-unique signature or offset for the local gamedata entry "CCSCustomHudLayout_SetDialogVariableString" (symbol CCSCustomHudLayout_SetDialogVariableString). The gamedata consumer stores a BYTE SIGNATURE for this entry - ALWAYS emit the func schema (func_sig), never vfunc fields. The function may be virtual; locating it via the owning class vtable (RTTI) is a fine strategy, but once found, read its head bytes and emit func_sig. Locate via cross-references, distinctive constants/strings, callers of related symbols, or vtable slots; verify by decompilation before committing. Trigger: CCSCustomHudLayout_SetDialogVariableString, CCSCustomHudLayout_SetDialogVariableString

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処理の高速化を、現状の計測、仮説ごとの変更案の比較、正しさの検証へ分解し、時間や費用の上限内で最も速い安全な案と再実行できる手順を残すスキル。

• 遅い処理を計測しながら高速化したいとき
• 同じ入力条件で実装案を比較したいとき
• 応答時間・処理量・実行費用の評価

Looks up precomputed AlphaGenome Atlas effects for any GRCh38 single-nucleotide variant (AVI score with Phred and 18 SHAP feature attributions, plus raw and quantile scores for RNA-seq, DNase, ATAC, ChIP-TF, ChIP-histone, CAGE, PRO-cap, splicing, polyadenylation and contact-map tracks), scores variants or scans windows on demand with the AlphaGenome model for human and mouse (variant scoring, in silico mutagenesis, REF-versus-ALT track prediction), and builds Atlas website deep links. Use when the user mentions AlphaGenome, AlphaGenome Atlas, AVI or AlphaGenome Variant Impact, DeepMind variant effect prediction, or wants to prioritise or mechanistically interpret non-coding, regulatory, splicing, enhancer, promoter, or chromatin-accessibility effects of SNVs from a VCF, credible set, or region. Research use only; not a clinical tool.

日本語の概要は準備中です。原文の説明を表示しています。

Build or update a professional-grade design system in Figma from a codebase. Use when the user wants to create variables/tokens, build component libraries, create individual components with proper variant sets and variable bindings, set up theming (light/dark modes), document foundations, or reconcile gaps between code and Figma. Also use when the user asks to create or generate any component in Figma — even a single one — since components require proper variable foundations, variant states, and design token bindings to be production-quality. This skill teaches WHAT to build and in WHAT ORDER — it complements the `figma-use` skill which teaches HOW to call the Plugin API. Both skills should be loaded together.

日本語の概要は準備中です。原文の説明を表示しています。

Build or update a professional-grade design system in Figma from a codebase. Use when the user wants to create variables/tokens, build component libraries, create individual components with proper variant sets and variable bindings, set up theming (light/dark modes), document foundations, or reconcile gaps between code and Figma. Also use when the user asks to create or generate any component in Figma — even a single one — since components require proper variable foundations, variant states, and design token bindings to be production-quality. This skill teaches WHAT to build and in WHAT ORDER — it complements the `figma-use` skill which teaches HOW to call the Plugin API. Both skills should be loaded together.

日本語の概要は準備中です。原文の説明を表示しています。

[omh] Technical proposal facing adversarial scrutiny: independent perspectives attack a proposal, then distill into a bundle a separate planner consumes. Use when the user says: adversarial-consensus, adversarial planning, adversarial plan review, red team this plan, red-team this plan, red team the proposal, multi-perspective review, multiple perspectives.

日本語の概要は準備中です。原文の説明を表示しています。

Assign pathogen lineages and track variants using Nextclade and pangolin for viral surveillance. Monitor variant prevalence and identify emerging variants of concern. Use when classifying viral sequences, tracking lineage dynamics, or monitoring for variants of concern.

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Use when running prognostic survival analysis on a clinical cohort with time-to-event data to estimate univariate and multivariable Cox proportional hazards models, export result tables, and generate forest plots. NOT for: nomogram construction, calibration curves, time-dependent ROC analysis, or model training/feature selection beyond the built-in univariate screening rule.

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Produce a structured budget variance analysis from actual vs budget figures. Use when asked to analyse budget variances, explain underspend or overspend, write a variance commentary, or investigate why actuals differ from plan. Produces a categorised variance table with root cause analysis and management commentary.

日本語の概要は準備中です。原文の説明を表示しています。

Manages Fabric Variable Library items, including definitions, libraryVariables and valueSets overrides. Covers which consumers can reference a variable and with what syntax -- pipelines, notebooks via notebookutils variableLibrary, Dataflow Gen2, Copy Jobs, shortcuts, UDFs and Plan items -- the active value set per workspace or deployment stage, and Git serialization for CI/CD.

日本語の概要は準備中です。原文の説明を表示しています。

Perform a structured maintainer-style PR review for the mariadb-operator repository. Gathers PR context, triages the change, and evaluates correctness, safety, pitfalls, backwards compatibility and code quality against the project conventions documented in AGENTS.md. Use whenever the user mentions a mariadb-operator PR number or URL and wants any kind of judgment on it — "review this PR", "what do you think of #1234", "is this safe to merge", "assess this diff", "take a look at this change" — even if they don't literally say "review".

日本語の概要は準備中です。原文の説明を表示しています。

Create the release notes and upgrade guide for a mariadb-operator release. Given the release PR whose body lists every PR included in the release, it gathers each PR, groups the changes by relevance, and produces `docs/releases/RELEASE_<version>_HEADER.md.gotmpl` and `docs/releases/UPGRADE_<version>.md` in the format the previous releases use, then opens a PR targeting `release-<version>`. If no release PR is provided it asks for the new version and infers the changes from git history since the last tag. Use whenever the user wants release notes, an upgrade/update guide, or docs for a new mariadb-operator version — "create the release notes for 26.10.0", "write the upgrade guide", "document this release", "prepare the release PR docs" — even if they don't mention a release PR.

日本語の概要は準備中です。原文の説明を表示しています。

Write variance commentary for A-share financial results. Adapts the original variance-commentary skill for Chinese financial statements, CAS conventions, and Chinese business terminology. Triggers on "A股业绩点评", "财报点评", "variance commentary China", "业绩分析", "variances [company]", or "commentary on [company] results".

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SpatialFeatureExperiment (SFE) is a new S4 class for working with spatial single-cell genomics data. The voyager package implements basic exploratory spatial data analysis (ESDA) methods for SFE. Univariate methods include univariate global spatial ESDA methods such as Moran's I, permutation testing for Moran's I, and correlograms. Bivariate methods include Lee's L and cross variogram. Multivariate methods include MULTISPATI PCA and multivariate local Geary's C recently developed by Anselin. The

日本語の概要は準備中です。原文の説明を表示しています。

Guide to quality filtering raw VCF files before computing summary stats (Ts/Tv ratio, variant counts, AF distributions). Covers detecting raw VCFs via FILTER column and QUAL inspection, QUAL-based filtering with bcftools, Ts/Tv interpretation, and when NOT to filter. Read before any variant-level QC task. See bcftools-variant-manipulation for advanced filters, gatk-variant-calling for caller config, samtools-bam-processing for upstream alignment QC.

日本語の概要は準備中です。原文の説明を表示しています。

Online (incremental) covariance, correlation, and precision estimation in Python — the streaming complement to sklearn.covariance. Use when code needs a covariance/correlation matrix updated per observation, recomputes np.cov/np.corrcoef in a rolling loop, must judge or compare covariance estimates, or proposes a new covariance methodology. Points to task-specific skills.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when reasoning about generative AI, adversarial machine learning, neural network security, algorithmic fairness, or deep learning fundamentals. This skill channels the thinking of Ian Goodfellow, inventor of Generative Adversarial Networks (GANs). Trigger this skill when the user asks about model robustness, mitigating bias, evaluating AI guardrails, designing generative models, or defending against adversarial attacks. Apply his frameworks of minimax games, adversarial feature learning, and worst-case robustness analysis to shift the user's perspective from average-case optimization to adversarial resilience.

日本語の概要は準備中です。原文の説明を表示しています。

Query ClinVar for clinical variant significance. Use when user asks about variant pathogenicity, genetic variants, clinical significance, or disease-causing mutations. Triggers on "clinvar", "pathogenic", "variant significance", "clinical significance", "disease variant", "mutation pathogenicity".

日本語の概要は準備中です。原文の説明を表示しています。

Manage environment variables and secrets across development, staging, and production environments. Use when someone needs to audit env vars, sync secrets between environments, detect missing or mismatched variables, rotate credentials, or set up a new environment from an existing one. Trigger words: env vars, environment variables, secrets, .env file, dotenv, config management, secret rotation, missing variable, environment sync.

日本語の概要は準備中です。原文の説明を表示しています。

Use this skill when reasoning about generative AI, adversarial machine learning, neural network security, algorithmic fairness, or deep learning fundamentals. This skill channels the thinking of Ian Goodfellow, inventor of Generative Adversarial Networks (GANs). Trigger this skill when the user asks about model robustness, mitigating bias, evaluating AI guardrails, designing generative models, or defending against adversarial attacks. Apply his frameworks of minimax games, adversarial feature learning, and worst-case robustness analysis to shift the user's perspective from average-case optimization to adversarial resilience.

日本語の概要は準備中です。原文の説明を表示しています。

N-round adversarial review pipeline for empirical research output — the chain from data to LaTeX tables to a manuscript that cites them. A Claude drafter proposes minimal diffs, a deterministic mechanical battery gates every diff from a clean state with a regression gate, a Codex reviewer files check-backed critiques, and a blind judge panel decides residual disputes. Manual-invoke ONLY: trigger when the user explicitly runs /adversarial-empirical-review or names 'adversarial-empirical-review' / 'adversarial empirical review'. Do NOT auto-trigger on generic 'review my results', 'check my tables', or manuscript-editing requests. For prose-style refinement use style-emulation instead; this skill AUDITS WHETHER THE TABLES ARE CORRECT — that each number in the tables is what the analysis code computes, reproduces from the data, and is internally consistent. It is an empirical + code review: the manuscript is read only to resolve table numbering, and prose is not examined.

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Orientação de liderança técnica para equipes de engenharia, decisões de arquitetura e estratégia de tecnologia. Inclui analisador de débito técnico, calculadora de escalabilidade de equipes, frameworks de métricas de engenharia, ferramentas de avaliação de tecnologia e templates de ADR. Use ao avaliar débito técnico, escalar equipes de engenharia, avaliar tecnologias, tomar decisões de arquitetura, estabelecer métricas de engenharia ou quando o usuário menciona CTO, débito técnico, débito técnico, escalabilidade de equipes, decisões de arquitetura, avaliação de tecnologia, métricas de engenharia, métricas DORA ou estratégia de tecnologia.

日本語の概要は準備中です。原文の説明を表示しています。