「binding」の検索結果

Guide for theming .NET MAUI apps — light/dark mode via AppThemeBinding, ResourceDictionary theme switching, DynamicResource bindings, system theme detection, and user theme preferences. Use when: "dark mode", "light mode", "theming", "AppThemeBinding", "theme switching", "ResourceDictionary theme", "dynamic resources", "system theme detection", "color scheme", "app theme", "DynamicResource". Do not use for: localization or language switching (see .NET MAUI localization documentation), accessibility visual adjustments (see .NET MAUI accessibility documentation), app icons or splash screens (see .NET MAUI app icons documentation), or Bootstrap-style class theming (see Plugin.Maui.BootstrapTheme NuGet package).

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Predict peptide-MHC class I and II binding affinity using MHCflurry and NetMHCpan neural network models. Identify potential T-cell epitopes from protein sequences. Use when predicting MHC binding for vaccine design or neoantigen identification.

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Differential binding analysis using DiffBind. Compare ChIP-seq peaks between conditions with statistical rigor. Requires replicate samples. Outputs differentially bound regions with fold changes and p-values. Use when comparing ChIP-seq binding between conditions.

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Query BindingDB for measured drug-target binding affinities (Ki, Kd, IC50, EC50). Search by target (UniProt ID), compound (SMILES/name), or pathogen. Essential for drug discovery, lead optimization, polypharmacology analysis, and structure-activity relationship (SAR) studies.

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Audit one, several, or all existing Octane bindings; implement selected maintenance findings or remove redundant copied files with evidence matched to source ownership. Use for binding updates, lifecycle fixes, dependency or metadata maintenance, and convenience-import requests.

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Implement and verify new React-library ports or copied/rewritten React surfaces in Octane bindings from npm names or npm/GitHub links/lists. Enforces immutable provenance, license boundaries, dependency ordering, full-surface parity, and machine evidence. Existing-binding audits and maintenance start with update-bindings.

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Predict peptide-MHC class II (HLA-DR/DQ/DP) binding and presentation for CD4 T-cell epitopes with NetMHCIIpan-4.3 and MixMHC2pred-2.0. Covers why class II is far less reliable than class I (open binding groove, 9-mer register ambiguity, sparse noisy training data, DR>DP>DQ accuracy asymmetry), the DQ/DP heterodimer alpha/beta pairing trap, and the looser 1%/5% %Rank thresholds. Use when predicting CD4 epitopes for vaccine help, mapping class II neoantigens, or scoring long peptides against DR/DQ/DP. For CD8/class I see mhc-binding-prediction.

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Infer or annotate TCR antigen specificity by unsupervised clustering (TCRdist/tcrdist3, GLIPH2, clusTCR, GIANA) and database lookup (VDJdb, IEDB, McPAS-TCR), and rank candidates with supervised predictors (ERGO-II, NetTCR-2.x, pMTnet) under explicit caveats. Encodes the central truth that general TCR-epitope prediction for UNSEEN epitopes essentially does not work (collapses to near-random; IMMREP22, Grazioli 2022) because labeled data is dominated by a few immunodominant epitopes and there is no true negative set — so clustering for discovery is the honest task and de-novo binding needs wet-lab validation. Use when annotating TCR specificity or grouping a repertoire. Epitope/MHC context lives in mhc-binding-prediction.

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Identify tumor neoantigens from somatic variants with pVACtools (pVACseq/pVACfuse/pVACbind/pVACvector/pVACview) for personalized cancer vaccines and checkpoint biomarkers. Encodes the field's hard truth that binding prediction is the easy, near-solved part and single-digit-percent PPV lives downstream — so it centers clonality/CCF, HLA LOH (the silent invalidator), expression, proximal-variant phasing, agretopicity/foreignness quality, and the predicted->presented->immunogenic validation tiers. Use when nominating vaccine targets, ranking neoantigens, or building a tumor-to-candidate pipeline. Binding details in mhc-binding-prediction; ranking in immunogenicity-scoring.

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Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Query BindingDB for protein-ligand binding affinity data

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Bind papers to chapter-level sections first, writing `outline/section_bindings.jsonl` and `outline/section_binding_report.md`.

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Guidance for configuring dependency injection in .NET MAUI apps — service registration in MauiProgram.cs, lifetime selection (Singleton / Transient / Scoped), constructor injection, Shell navigation auto-resolution, platform-specific registrations, and testability patterns. USE FOR: "dependency injection", "DI setup", "AddSingleton", "AddTransient", "AddScoped", "service registration", "constructor injection", "IServiceProvider", "MauiProgram DI", "register services", "BindingContext injection". DO NOT USE FOR: data binding (use maui-data-binding), Shell route configuration (use maui-shell-navigation), unit-test mocking frameworks (use standard xUnit and NSubstitute patterns).

日本語の概要は準備中です。原文の説明を表示しています。

Guide for theming .NET MAUI apps — light/dark mode via AppThemeBinding, ResourceDictionary theme switching, DynamicResource bindings, system theme detection, and user theme preferences. Use when: "dark mode", "light mode", "theming", "AppThemeBinding", "theme switching", "ResourceDictionary theme", "dynamic resources", "system theme detection", "color scheme", "app theme", "DynamicResource". Do not use for: localization or language switching (see .NET MAUI localization documentation), accessibility visual adjustments (see .NET MAUI accessibility documentation), app icons or splash screens (see .NET MAUI app icons documentation), or Bootstrap-style class theming (see Plugin.Maui.BootstrapTheme NuGet package).

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Create, modify, debug, or review Windows Forms applications only when the request contains a concrete Windows Forms marker. USE FOR: WinForms, Windows Forms, System.Windows.Forms, WinForms Form or UserControl designer files (*.Designer.cs or *.Designer.vb), Visual Studio WinForms Designer, TableLayoutPanel, BindingSource, DataGridView, Control.InvokeAsync, component-tray ownership, or custom control serialization. DO NOT USE FOR: WPF or WPF XAML, including Window.InputBindings, KeyBinding, commands, or DataContext; .NET MAUI; Avalonia; or any request where none of the listed Windows Forms markers is present.

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Guides development and approval of Binding Corporate Rules under GDPR Article 47 for intra-group international data transfers. Covers Art. 47(2)(a)-(n) content requirements, BCR approval process with lead supervisory authority, and WP256/WP257 referentials. Keywords: BCR, binding corporate rules, intra-group transfers, Art. 47.

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Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda window scheduling, soft-core potentials, REST2 enhanced sampling, MBAR/BAR analysis, and cycle closure validation. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。

Generate Unity 6+ UI Toolkit Runtime Data Binding code using MVVM pattern with [CreateProperty], DataBinding, and PropertyPath. Use when creating UI screens, HUDs, menus, inventories, settings panels, or any data-bound UI elements with UI Toolkit. Triggers on requests like "create a health bar", "build the HUD", "make a settings screen", "bind data to UI", "create an inventory UI", "add a pause menu", "show player stats on screen", "build a shop UI", "create a dialogue box", or any task involving runtime UI layout, styling, or data display. Also use when the user mentions UXML, USS, ViewModel, or UI bindings. Only activates when ProjectConfig.yaml -> ui_system is "UIToolkit" or "Mixed". Requires Unity 6.0+.

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Guide for de novo and known motif enrichment analysis of ENCODE ChIP-seq and ATAC-seq peaks using HOMER and MEME Suite. Use when users need to discover TF binding motifs in peaks, validate ChIP-seq targets, or find co-binding partners. Trigger on: motif analysis, HOMER, MEME, de novo motif, motif enrichment, findMotifsGenome, AME, MEME-ChIP, known motif, TF binding motif, co-factor, motif discovery.

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Drafts U.S. Customs and Border Protection binding ruling requests under 19 CFR Part 177 for tariff classification, valuation, origin, and marking determinations. Trigger when input mentions "binding ruling," "CBP ruling request," "19 CFR Part 177," "classification request," "HTSUS analysis," "transaction value," "country of origin," or "marking for import."

日本語の概要は準備中です。原文の説明を表示しています。

Performs alchemical free-energy calculations including relative binding free energy (RBFE / FEP+) and absolute binding free energy (ABFE) via OpenFE, FEP+, GROMACS, AMBER pmemd, and OpenMM with explicit lambda scheduling, soft-core potentials, MBAR/BAR analysis, cycle-closure validation, and protocol-appropriate enhanced sampling. Compares ML alternatives (Boltz-2 affinity, DeepDock). Use when ranking analogs by binding affinity beyond docking accuracy, performing prospective lead optimization, or validating SAR predictions.

日本語の概要は準備中です。原文の説明を表示しています。

Detects allele-specific transcription factor or histone modification binding from heterozygous-variant ChIP-seq using WASP (reference-bias filter; mandatory upstream), RASQUAL (joint QTL + bias-corrected testing), BaalChIP (Bayesian beta-binomial with copy-number-aware overdispersion), and AlleleSeq (personalized diploid genome). Handles imprinted-locus awareness, X-inactivation artifacts, cancer copy-number imbalance, and integration with downstream caQTL / bQTL mapping. Use when identifying variants with allelic effects on TF binding, fine-mapping causal regulatory variants, validating deep-learning variant predictions, or characterizing cis-acting regulatory effects.

日本語の概要は準備中です。原文の説明を表示しています。