「dto」の検索結果

Computes and interprets sequencing read depth and coverage over a genome, windows, or target regions with mosdepth (windowed depth, cumulative distribution, --quantize callable BEDs), bedtools genomecov/coverage (bedGraph tracks, per-target stats), samtools depth/coverage (per-base depth, per-contig depth+breadth). Covers the breadth-vs-mean distinction, the cumulative-coverage curve, evenness (CV/Fano/fold-80/Gini), what each tool silently counts (duplicates, secondary/supplementary, MAPQ, read span vs fragment, mate-overlap), the samtools-depth 8000-cap version trap, and the bedtools coverage -a/-b orientation flip. Use when assessing sequencing adequacy, building coverage tracks, computing breadth at a depth threshold, defining callable regions, or QCing target-capture uniformity.

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Tests whether two genomic interval sets overlap (colocalize) more than expected by chance using a permutation test against a structured-genome null model. Covers bedtools fisher (analytic 2x2 screen), bedtools shuffle + jaccard permutation, GAT (isochore/GC-conditioned simulation with FDR), regioneR (flexible permutation, randomizeRegions vs circularRandomizeRegions, localZScore), LOLA (universe-relative Fisher against a region database), and GREAT/rGREAT (regulatory-domain binomial + hypergeometric for ontology-from-regions). Stresses the universe/background choice, matched background, blacklist exclusion, and multiple-testing control. Use when asking whether peaks/regions are enriched at enhancers/TFBS/features, scoring region-set colocalization or region-set enrichment, comparing CNV/SV concordance, or turning an overlap count into a defensible p-value.

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Generates, normalizes, and converts bedGraph signal tracks (4-column chrom/start/end/value, 0-based half-open) with bedtools genomecov, deepTools bamCoverage/bamCompare/bigwigCompare, bedtools unionbedg, and UCSC bedGraphToBigWig. Covers why a raw coverage bedGraph is not comparable across samples until normalized, the CPM/RPKM/BPM/RPGC normalization menu and the conserved-total assumption that makes them wrong under a global perturbation, the strict sorted-non-overlapping-chrom.sizes bedGraphToBigWig contract that silently corrupts a bigWig, effective-genome-size selection, and bin-size aliasing. Use when building or normalizing a coverage/signal track from a BAM, comparing tracks across samples or conditions, converting bedGraph to a browser-ready bigWig, or diagnosing a track that looks plausible but reports wrong heights.

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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Выгрузка пакета XDTO 1С в XML-схему (XSD). Используй когда нужно получить схему существующего пакета — чтобы переработать её целиком, отдать контрагенту или перенести пакет в другую конфигурацию

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Точечное редактирование пакета XDTO 1С. Используй когда нужно добавить, изменить или удалить тип или свойство в существующем пакете, переименовать пакет, сменить пространство имён

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Build secure, reusable data access patterns with DTOs, taint checks, and colocated authorization in Next.js. Use when centralizing database queries, transforming raw data to DTOs, adding server-only guards, or preventing sensitive data from reaching Client Components.

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Implement Domain-Driven Design with typed DTOs, repository interfaces, and single-responsibility Action classes in Laravel. Use when creating domain folders, binding repository contracts in providers, or passing DTOs between layers.

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Use when you need to design, review, or improve REST APIs with Micronaut — including @Controller routes, HTTP status codes, DTOs, Bean Validation, exception handlers, pagination, idempotency, ETag/If-Match, caching headers, versioning, contract-first OpenAPI (OpenAPI Generator), optional runtime OpenAPI via micronaut-openapi, and security annotations. This should trigger for requests such as Review or improve Micronaut @Controller REST APIs; Add validation, error handling, or align controllers with the OpenAPI contract on Micronaut HTTP layer; Design Micronaut controllers and DTO validation; Add Micronaut exception handlers and Problem Details responses; Improve pagination filtering or OpenAPI alignment in Micronaut APIs. Part of Plinth Toolkit

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Use when you need to design, review, or improve validation in Spring Boot applications — including Bean Validation on request DTOs, @Valid/@Validated at API boundaries, constraint groups, custom constraints, @ConfigurationProperties validation, nested DTO validation, and consistent validation error handling. This should trigger for requests such as Add validation support in Spring Boot; Review Spring Boot validation rules; Improve request validation in Spring Boot REST APIs; Add custom Bean Validation constraints in Spring Boot; Validate configuration properties in Spring Boot. Part of Plinth Toolkit

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Use when you need data access with Quarkus Hibernate ORM Panache — including PanacheEntity / PanacheEntityBase, PanacheRepository, named queries, JPQL, native SQL, DTO projections (project(Class)), pagination (Page.of()), N+1 avoidance (JOIN FETCH), optimistic locking (@Version / OptimisticLockException), @NamedQuery for validated reusable queries, transactions, @TestTransaction for test isolation, and immutable-friendly patterns. This is the Quarkus analogue to Spring Data for relational persistence. This should trigger for requests such as Review Panache entities or repositories in Quarkus; Improve Hibernate ORM data access with Panache; Add DTO projections, JOIN FETCH, pagination, or optimistic locking to Panache queries; Fix N+1 query problems or add @Version concurrency control in Quarkus Panache; Improve Panache active record versus repository design. Part of Plinth Toolkit

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PowerX CRUD DTO 规则（输入输出分离、分页、校验）。

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Provides patterns for unit testing mappers, converters, and bean mappings. Validates entity-to-DTO and model transformation logic in isolation. Generates executable mapping tests with MapStruct and custom converter test coverage. Use when writing mapping tests, converter tests, entity mapping tests, or ensuring correct data transformation between DTOs and domain objects.

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Provides comprehensive NestJS best practices including modular architecture, dependency injection scoping, exception filters, DTO validation with class-validator, and Drizzle ORM integration. Use when designing NestJS modules, implementing providers, creating exception filters, validating DTOs, or integrating Drizzle ORM within NestJS applications.

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Owns repositories, data sources and mapping for Compose and Compose Multiplatform apps: DTO to domain to UiModel boundaries, Ktor clients and bearer auth, WebSocket and SSE, Room, DataStore, Paging 3, offline-first and data-layer tests. Use when writing or reviewing a repository, data source, DTO, mapper, HttpClient, bearer token, WebSocket, SSE, Room DAO, migration, DataStore, PagingSource, RemoteMediator, offline cache or MockEngine test. Do NOT use for ViewModel or UI wiring (compose-feature), composables (compose-ui), the MVI contract or error tiers (compose-architecture), Gradle modules (compose-project), or commonMain vs platform splits (compose-platform).

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Annotate copy number variant segments with overlapping genes, dosage-sensitivity scores, cancer driver databases, population frequencies, and clinical-variant content. Covers bedtools/pybedtools interval intersection, AnnotSV comprehensive annotation and ranking, ClinGen haploinsufficiency/triplosensitivity scoring, gnomAD-SV/DGV frequency filtering, COSMIC Cancer Gene Census, and ClinVar overlap. Use when interpreting which genes a CNV affects, distinguishing the driver gene of a focal event from passengers, filtering against population CNVs, separating whole-gene from partial-gene overlap, or preparing CNVs for clinical classification.

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BED file format fundamentals, creation, validation, and basic operations. Covers BED3 through BED12 formats, coordinate systems, sorting, and format conversion using bedtools and pybedtools. Use when working with genomic coordinates or preparing interval files for downstream tools.

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DDDにおけるリポジトリの設計ルールとアンチパターンを提供する。集約単位の命名規則、 CQS（Command Query Separation）に基づくメソッド設計、入出力の型制約をチェックする。 コードレビュー、新規実装、リファクタリング時にリポジトリ設計の問題を検出する場合に使用。 対象言語: 言語非依存（Java, Kotlin, Scala, TypeScript, Go, Rust, Python等すべて）。 トリガー：「リポジトリの設計をレビュー」「Repository名がおかしい」「findByIdの戻り値」 「リポジトリがDTOを返している」「テーブル名でリポジトリを作ってしまった」 「集約単位のリポジトリ」「リポジトリのアンチパターン」「リポジトリのCQS」 といったリポジトリ設計関連リクエストで起動。

Central authority for Claude Agent SDK (TypeScript and Python SDKs). Covers SDK installation, authentication (Anthropic key, Bedrock, Vertex), sessions and resumption, forking sessions, streaming vs single mode, custom tools, permissions (allowedTools, disallowedTools, permissionMode), MCP integration, system prompts (CLAUDE.md, appendSystemPrompt, outputStyle), cost tracking, todo tracking, structured outputs, hosting patterns, plugins, and SDK branding guidelines. Assists with building custom agents, configuring SDK options, and troubleshooting SDK issues. Delegates 100% to docs-management skill for official documentation.

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Sets standards for Data Transfer Objects (DTOs), typically records, including parameter validation in compact canonical constructors.

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Spring Boot coding conventions: REST controller design, service layer, dependency injection, configuration, DTO patterns, exception handling, and Bean Validation. Apply on any Spring Boot project. Works alongside spring-boot-plugin:spring-data-jpa for persistence and java-foundation:java-conventions for domain objects. Use this skill to: - Structure REST endpoints with @RestController, proper HTTP semantics, and DTO mapping. - Enforce constructor injection and @ConfigurationProperties over @Value on fields. - Write @Service classes with transactional boundaries at the right layer. - Handle errors consistently with @RestControllerAdvice and ProblemDetail (RFC 9457). Do NOT use this skill for: - JPA entity and repository patterns — see spring-boot-plugin:spring-data-jpa. - Spring Security configuration — see the security phase injection in stack.md. - Build tool configuration — see java-foundation:build-tooling.

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Entity Framework Core patterns for ASP.NET Core projects: DbContext design, code-first entity configuration (Fluent API via IEntityTypeConfiguration<T>), relations (HasOne/HasMany, cascade/restrict/set-null), indexes and unique constraints, projection to DTOs (Select + AsNoTracking), avoiding N+1 (Include, AsSplitQuery), transactions, parameterized raw SQL (FromSql with FormattableString), and connection string from IConfiguration. Works alongside aspnet-core-plugin:aspnet-conventions. Use this skill to: - Design a clean DbContext with ApplyConfigurationsFromAssembly for scalable entity registration. - Configure entity properties (column types, max length, precision, nullability) via Fluent API. - Avoid N+1 query problems with explicit Include / projection to DTOs. - Use transactions correctly for multi-entity operations. - Write parameterized raw SQL safely when LINQ is not expressive enough. Do NOT use this skill for: - Migration generation commands (that is efcore-specialist's job in the database extra phase). - ASP.NET Core middleware, DI, or validation — see aspnet-core-plugin:aspnet-conventions. - C# language idioms — see csharp-foundation:csharp-conventions.

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Build a full feature in this Flutter repository that includes backend or storage data flow: read API schema, create DTOs, map DTOs to entities, add Riverpod use cases, connect feature state, and render UI data. Use when a task goes beyond a screen and needs real data integration.

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Design the engagement model for an Experience Cloud community: reputation levels, ideation, and content contribution strategy. Triggers: 'community engagement strategy', 'gamification Experience Cloud', 'reputation levels setup', 'ideation community portal', 'member recognition program'. NOT for blocking, flagging or approving what members post — use admin/experience-cloud-moderation. NOT for measuring logins, page views or engagement after launch — use data/community-analytics-data. Also covers: the Network reputation elements that carry the ladder (enableReputation, reputationLevels/level/label/lowerThreshold, reputationPointsRules/pointsRule/eventType/points), the 16 documented reputation eventType values and their default points, ManagedTopics / ManagedTopic (Navigational vs Featured, position 0-24), NetworkMember.ReputationPoints seeding, and why FeedItem cannot carry the engagement dashboard.

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